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When do you think we are going to get a DMARD for OA? 50% or more over age 60 will have osteoarthritis, yet we are yet to discover a promising disease modifying therapy. #ACR20 @RheumNow @ElaineHusniMD
Meral K. El Ramahi, MD MeralElRamahiMD ( View Tweet)
When you give IA steroids for knee OA how long do you tell pts it will work for @RheumNow #ACR20 @CRASCRRheum abstr#1650
Janet Pope Janetbirdope ( View Tweet)
Using a panel of urinary prtns, data from this study show transferrin, AGP1, ceruloplasmin, MCP1 & sVCAM1 are sig. ⬆in active LN pts.
More studies req'd for confirmation.
Utility in monitoring renal response to tx?
@RheumNow #ACR20 abs1796 https://t.co/3Zicpz3uDd
sheila RHEUMarampa ( View Tweet)
I recommend you don’t try this at home. Bariatric surgery may delay need for TKA in knee OA. Supports that et loss may help. Comparison study NOT RCT of 25 bariatric pts with knee OA compared to 28 with TKA abstr#1656 #ACR20 @RheumNow @CRASCRRheum
Janet Pope Janetbirdope ( View Tweet)
Intra-articulations steroids for the knee OA- finding benefits again! IA steroids were good then villified in press with accelerated cartilage loss. Pendulum swings back in abstr#1649 where quadriceps & gait improve post injection @RheumNow #ACR20 @CRASCRRheum #ACRbest https://t.co/0bRsiEKsW4
Janet Pope Janetbirdope ( View Tweet)
Since MTX doesn’t work in cardiac prevention in non inflammatory pop’n (CIRT trial) should we use MTX in knee OA with inflammation? RCT n=344 w primary knee OA w swelling & pain. Rx MTX v glucosamine POSITIVE results #ACR20 abstr#1648 @RheumNow @CRASCRRheum #ACRbest https://t.co/7VptCPxKU8
Janet Pope Janetbirdope ( View Tweet)
#osteoarthritis Rx with #tanezumab - analgesic or DMOAD? RCT in knee OA of 3021 pts & only 1312 completed Rx. Tanezumab > improvement in pain v NSAIDs but NO diff in MCII and pt acceptable symptoms (PASS) over time #ACR20 #ACRbest abstr#1641 @RheumNow @CRASCRRheum https://t.co/x75ncz16uP
Janet Pope Janetbirdope ( View Tweet)
#EULAR2020 #op0327 AI stages knee OA radiograpgic chsnges ieth accuracy 91.8-99% in 95% of the cases. Would you prefer AI or human radiology readings for MSK imaging ? @RheumNow
Olga Petryna DrPetryna ( View Tweet)
#Multimorbidity in #RheumaticDisease: Abs#1466:
-Highly prevalent across RA, PsA, gout & OA
-Highest burden in #gout
Important study highlighting need to recognise burden of MM in #rheumatology patients for holistic optimised management.
#ACR20 @RheumNow
https://t.co/esinnHoUME https://t.co/bApXfx7hOU
Mrinalini Dey DrMiniDey ( View Tweet)
Dr England presents on multimorbidity in RA, PsA, gout, and OA within RISE registry. Highly prevalent in all 4 but most pronounced in gout and RA. Critical to recognise and manage. @rheumnow #ACR20 Abstr#1466 https://t.co/XtwIfJnVXV
Richard Conway RichardPAConway ( View Tweet)
Liraglutide as a Potential Intra-Articular Treatment for Cartilage Regeneration in Osteoarthritis: In Vitro and In Vivo Studies Supporting a Pro-Chondrogenic Effect https://t.co/T9IqF7E00Z #OA #DMOAD a potential DMOAD in mice
Peter Nash drpnash ( View Tweet)
@Janetbirdope @RheumNow @CRASCRRheum This study is a follow-on to an existing body of evidence re: vitamin K-dependent proteins ("Gla" proteins) in #OA, as well as warfarin VK antagonist effects, and agnostic discovery in a GWAS. The findings hold including in studies unrelated to access to care and a small RCT.
Tuhina Neogi, MD, PhD Tuhina_Neogi ( View Tweet)
It's only now we have choices to warfarin that we can realise the effect of vit K blockade on OA.
Nested case-control (AF pts, UK primary care):
warfarin has risk vs DOAC for end-stage OA (via joint replacement) aOR 1.25
esp knee aOR 1.48
@Tuhina_Neogi #ACR20 ABST0934 @RheumNow https://t.co/XVLG8kIL0W
David Liew drdavidliew ( View Tweet)
Plenary session: Dr Ballal presents data showing #warfarin use incr. risk of knee/hip replacements, compared to #DOACs
- Nest case-control study in UK THIN database
- Risk increases w/ duration of use
- Indicates need for well-powered RCT of vit K in OA
Abs#0934 #ACR20 @RheumNow https://t.co/YyxDjNQEjx
Mrinalini Dey DrMiniDey ( View Tweet)
Amazing to see a plenary by a 1st year fellow @BU_BMC_Rheum - Vit K is important in preventing #OA progression - obs study #Warfarin has higher knee and hip replacement risk compared to #DOACs #ACR20 @RheumNow ABS#0934 https://t.co/0IUS8QvzI4
Bella Mehta bella_mehta ( View Tweet)
Abst#0934 by Dr. Ballal at BU looks at the role of vitamin K deficiency in OA development. Warfarin use with 57% increased risk of TKA/THA compared to NOAC, though diminished when accounting for signif practice variation in these patients @Rheumnow #ACR20 https://t.co/PsESoeurKF
Eric Dein ejdein1 ( View Tweet)
Scoring hand x-rays for Sharp scores is painfully tedious and not always perfectly consistent.
Why not get a computer to do it? Turns out you can - a deep adaptive machine learning model does as well as a human, each x-ray in literally one second.
#ACR20 ABST0493 @RheumNow https://t.co/SvqkaFy8XZ
David Liew drdavidliew ( View Tweet)
ACR 2020 Your Way - Get Your Topic Emails
ACR is but a few days away; the question is: how will you tackle this virtual meeting? RheumNow has created several options for learning the way you want to. First is to feed your need. Are you a lupologist? A gout maven? A Spondylitis sleuth? A drug safety wannabe?
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Wilson’s dz- autosomal recessive w/ incr copper deposition in brain, liver & joints (<50%) w/ premature OA in wrist, MCPs, knees & spine. Dx by LOW serum ceruloplasmin , HIGH urinary copper, hepatic copper levels, or mutations in ATP7B gene https://t.co/CoEpcjRnHt
Links:
Dr. John Cush RheumNow ( View Tweet)
RheumNow Podcast – ACR 20 is Coming to Town (10.30.20)
Dr Jack Cush overviews the RheumNow commitment, upcoming bonus coverage of ACR20 and the good news and journal reports from the past week on RheumNow.com
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