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Failed Osteoarthritis Pulse Ultrasound Study

MedPage Today

A promising therapy aimed at halting and even reversing the pathology underlying osteoarthritis (OA) of the knee failed to show any benefit in a randomized trial.

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Updated ACR/AAHKS Guidelines on Drug Use in Knee & Hip Arthroplasty Patients

ACR

The American College of Rheumatology and the American Association of Hip and Knee Surgeons released a summary of their updated guideline for the Perioperative Management of Antirheumatic Medication in Patients with Rheumatic Diseases Undergoing Elective Total Hip or Total Knee Arthroplasty.

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Diagnostic Delay in Axial Spondyloarthritis (2.25.2022)

Jack Cush, MD

Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow.com. This week, rheumatologic problems incited by respiratory infections, air pollution and how you live, now where you live.

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Positive Results from the DOA (Duloxetine in OsteoArthritis) Study

Jack Cush, MD

A pragmatic, open-label trial of osteoarthritis (OA) patients demonstrated that adding duloxetine treatment seems to be beneficial for end-stage knee OA patients with neuropathic-like symptoms (at risk of central sensitization).

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Hand OA and Heroes in Rheumatology (2.11.2022)

Jack Cush, MD

Interesting reports this week about dementia, who gets hand OA and a great list of women Heroes and Pillars of Rheumatology. Tune in as Dr. Jack Cush reviews the news and journal articles from this past week in RheumNow.com.

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Hand Pain Related to Obesity and Inflammatory Markers

Jack Cush, MD

Arthritis & Rheumatology has published the results of the Nor-Hand study, showing that pain hand osteoarthritis (OA) was related to a higher body mass index (BMI) and also to inflammatory adipokines, such as leptin.

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Why Would Hand OA Be Less Severe in Black People?

MedPage Today

Osteoarthritis (OA) of the hand was less severe according to objective and pain-related markers in Black patients versus those of other racial/ethnic groups after adjustment for known risk factors, researchers found.

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An Ounce of Prevention (2.4.2022)

Jack Cush, MD

Dr. Jack Cush reviews the news and journal reports from this past week on RheumNow.com.  He discusses the GI side effects of IL-17 inhibitors, downstream revenues from rheumatology care and dietary prevention of gout. 

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French study of "Pre-Hab" before Total Knee replacement (prospective, OL, randomized trial) in 262 Knee OA pts >50yrs; saw no benefit of PreHab before TKR. 4 d post surgery, functional independence was same in PreHab (34%) & control (27%) https://t.co/0kXMNEfz4b. https://t.co/yhzk2MyZE3

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Dr. John Cush RheumNow ( View Tweet)
Most chronic pain is as you would think, back pain and OA. Dr. @Tuhina_Neogi #RNL2022 @RheumNow https://t.co/0thMj6mzjp
Dr. Rachel Tate uptoTate ( View Tweet)
Top February Tweet: Positive Results from the DOA (Duloxetine in OsteoArthritis) Study https://t.co/Is56PBxpIr https://t.co/xEh6zbx9nr

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Dr. John Cush RheumNow ( View Tweet)
Diabetes (HR 1.29), bad glycemic control (HR 1.41), and long-term diabetes (>5yrs HR 1.49) are potential risk factors of symptomatic knee OA, independent of age and BMI. Targeting blood glucose, in addition to obesity, may prevent knee OA. https://t.co/6XXVfLumqG https://t.co/ypz8avcjVs

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Dr. John Cush RheumNow ( View Tweet)
Osteoarthritis Initiative study looked at Hand OA. Among 3588 participants, 41% had hand OA by xray and 12.4 % by Sxs. Over 4 yrs, 27.3 % showed Xray OA progression. More in women (DIPs)>men (MCPs), but less in blacks https://t.co/WRZYcL7zFH

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Dr. John Cush RheumNow ( View Tweet)

Despite guidelines rec against hyaluronic acid knee injections, HA injx by ortho significantly increased from 1,090,503 in 2012 to 1,209,489 in 2018 (p = 0.04).amongsts Medicare beneficiaries https://t.co/fIEb5pq20I

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Dr. John Cush RheumNow ( View Tweet)

Retrospective study of 84 pts with Erosive Hand OsteoArthritis (EHOA)- 89% females DIPs erosions scores were higher than PIP’s. Comorbid dz = crystal arthritis (8%), RA (5%) & PsA (1%), Pain usually >5/10 w/ 1/3 responding to NSAIDs. Big Unmet need! https://t.co/jQ3yNgaZBA

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Dr. John Cush RheumNow ( View Tweet)

ICYMI: Physical Therapy is More Cost-Effective than Intraarticular Steroids in Knee OA https://t.co/My5xa8vEaP https://t.co/lGL57nwJiZ

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Dr. John Cush RheumNow ( View Tweet)
791 knee OA pts studied for progression after steroid (GC) (n=629) vs hyaluronic (HA) injxn (n=162). Knee OA progression was similar between groups for JSN (RR 1.00) & K/L grade (1.03); but IA GC had slightly lower TKR (HR 0.75 [CI 0.51–1.09]) https://t.co/74eg2Zvdy1 https://t.co/soXb7bdq6O

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Dr. John Cush RheumNow ( View Tweet)
ICYMI: Duloxetine added to usual analgesics failed to improve pain in 132 hip or knee OA pts by WOMAC pain scores: 1) Dulox + usual care vs 2) Usual care showed no diff in pain at 3 mos or 12 mos. https://t.co/2luWWDYP81 https://t.co/KAmqlnofVv

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Dr. John Cush RheumNow ( View Tweet)
Can PPI accelerate knee OA? UK cohort compared need for TKR in adults over 50yrs on PPI or H2 blockers. Those on omeprazole and pantoprazole had 21%-3& more TKR than H2B (but not elevated with lansoprazole, rabeprazole (HR=0.97) https://t.co/5TqFV3TpjG

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Dr. John Cush RheumNow ( View Tweet)

Global Burden of Disease Study shows that globally, from 1990 to 2019, the age-standardized incidence rate (ASIR) of hip osteoarthritis increased from 17.02 per 100,000 persons to 18.70 per 100,000 persons https://t.co/OJOnkAw1Dy

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Dr. John Cush RheumNow ( View Tweet)

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