Lancet Rheumatology has published a population study of the rare suppressor of cytokine signalling 1 (SOCS1) insufficiency - an inborn error of immunity affecting the negative regulation of cytokine and growth factor signalling.
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A prospective study of patients with limited cutaneous lupus erythematosus shows that early introduction of hydroxychloroquine may prevent progression to systemic lupus erythematosus.
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Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow.com. Opioid deaths are down, IL-33 levels are up and Weight loss is in the news again this week!
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A US study shows that nearly two-thirds of the population had suboptimal 5-year sleep duration trajectories with a resultant 29% increase in risk of all-cause mortality.
Selective mutation of Traf1/cIAP2 (V196) interaction attenuates inflammatory responses that may contribute to rheumatoid arthritis activity. THis may lead to a new class of therapies for RA https://t.co/kYqAqGsSEA https://t.co/JWUN6iTvxa
I ALWAYS recommend paraffin wax baths for stiffness, RA, OA, PSS, etc.
Here are some instructions for home use https://t.co/CTI4K2kHf9 https://t.co/i0kO99vdYc
AbbVie Receives Positive CHMP Opinion for Upadacitinib (RINVOQ®) for the Treatment of Adults with Giant Cell Arteritis https://t.co/WP8JGpHc6p https://t.co/x9m870mCJ4
UK MRCP exam makeup:
Cardio 15%
Pharm 15%
Resp 10%
GI 10%
Neuro 10%
ID 8%
Endo 8%
RHEUM 6%
Heme 5%
Renal 5%
Derm 4%
Eye 2%
Psych 2% https://t.co/WG7X3B8a0Y https://t.co/9VF5LkLJjs
Cochrane review of TNF inhib. in #JIA shows TNFi efficacy, but uncertainty about LT safety, pain, function, & Dz control - esp compared to MTX. 9 studies, 678 JIApts, age 8-15 yrs (80% F), Dz duration 0.8-6.7 yrs. Withdrawls 1% v 3%; Serious AE 6% v 7% (PBO vs TNFi).… https://t.co/i35m5uzG1m https://t.co/VzJN9PmmMh
"Never take the advice of someone who has not had your kind of trouble"
- Sidney J. Harris https://t.co/xdB6u6OiPq
Ankle Fusion or Total Replacement?
In a large study of British patients needing surgical treatment for advanced arthritis in the ankle, fusion appeared to be a better option than total ankle replacement.
https://t.co/ZFbd2VinpP https://t.co/QCqMkxNLoQ
Schnitzler Syndrome: A Rare Autoinflammatory Disorder
A credible, quick overview
Chronic Urticaria
Monoclonal Gammopathy (
Recurrent Fever
Bone & Joint Pain
Elevated CRP &ESR https://t.co/sQ22t8Z46m https://t.co/nJOVCghoFa
Diagnoses via Immune ‘Fingerprints’
Science and researchers at Stanford Medicine have reported the use of Mal-ID (machine learning for immunological diagnosis) to analyze B and T cell receptors (BCRs and TCRs) sequences from human blood, showing the ability to predict health… https://t.co/nqyf4iaD10 https://t.co/wt5V6uxLYf
JAMA Case: A Woman With Painful Digital Ulcers - What would you order next?
- chest CT w/ myositis-specific autoAb panel
- dsDNA
- SCL-70 & Centromere Abs
- muscle biopsy https://t.co/t0WCIMtZg2 https://t.co/M1jBhnclLl
Misdiagnosis of Dermatomyositis
JAMA Dermatology reports a retrospective cohort study from Johns Hopkins reviewing mimic of dermatomyositis (DM), suggesting that DM and especially clinically amyopathic DM (CADM) are commonly and initially misdiagnosed as inflammatory skin… https://t.co/2SbGxxcPLm https://t.co/TtoxFIXg3Q
TNF Inhibitor Drug-Induced Lupus
A study from the FDA's adverse event reporting system (FAERS or Medwatch) database identified cases of drug induced systemic lupus erythematosus (SLE) in patients receiving tumor necrosis factor-α (TNF-α) inhibitors - a paradoxical reaction to… https://t.co/LYq0qxDtp3 https://t.co/vRYrBAIMEA
13% of the ~22 million people with traditional coverage received a telehealth betw 10-12/2023. Expansion of Medicare telehealth coverage during the COVID-19 pandemic is set to expire on March 31 , 2025. Most telehealth will expire if Congress does not act. https://t.co/mVy7s664OX https://t.co/BVH6Hv5553
Retrospect. study of 77 RA pts w/ +ANCA (age 62 yrs, 79%F. 65% RF+. 45% p-ANCA+; 42% MPO+. Diagnoses included: AAV (29%); GPA (45%), MPA (36 %); EGPA (5%). Renal (41%) & upper Resp (36%) were most freq. Pts w/ RA+AAV had more RF, MPO+, nodules, inflam eye Dz… https://t.co/NTvAhZY2y8 https://t.co/IAkWHtcTCo
CDC reports an unprecedented drop of ~24% in US drug overdose deaths (87,000 down from 114,000) in 12 mos prior to 9/24. Yet, overdose remains the leading cause of death for Americans aged 18-44 yrs https://t.co/REiaQx6NKd https://t.co/nzOMDgUYbS
Schnitzler Syndrome: A Rare Autoinflammatory Disorder
A credible, quick overview
Chronic Urticaria
Monoclonal Gammopathy (
Recurrent Fever
Bone & Joint Pain
Elevated CRP &ESR https://t.co/boYFFEVwII https://t.co/xKCUZb8o6A


