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Rare Risks Associated with BNT162b2 mRNA Covid-19 Vaccine

Jack Cush, MD

The current NEJM reports that the use of the Pfizer mRNA vaccine (BNT162b2) demonstrated a very low risk for certain serious adverse events, including the risk of myocarditis (1 to 5 events per 100,000 persons). 

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virus,injection,COVID,vaccine

ACR Guidance on Timing of 3rd Dose Booster with Immunomodulatory Drugs

ACR Press Release

The American College of Rheumatology has issued an updated version of its COVID-19 Vaccine Clinical Guidance for Patients with Rheumatic and Musculoskeletal Diseases following recent recommendations from the CDC that certain immunocompromised patients receive a third dose of an availabl

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covid vaccine

FDA Approves First COVID-19 Vaccine

Jack Cush, MD

Today, the U.S.

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RheumNow Podcast – Driving in Pain (8.20.2021)

Jack Cush, MD

You know, I'm a very good driver. We all think we're great drivers - but consider what it's like to drive in pain: would you be a good driver? Also, I want you to consider the diagnosis of calcium pyrophosphate dihydrate disease (CPPD). But first, let's look at a study out of Scotland, looking at military service and greater risk of hip and knee replacement.

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vaccine,mRNA,Covid,vial

Sustained Effectiveness of mRNA Vaccines Against COVID-19 Hospitalizations

MMWR

The CDC has reported that mRNA vaccine effectiveness against COVID-19–associated hospitalizations was sustained over 24 weeks; but there is evidence of waning protection amongst the immunosuppressed.

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2021–22 influenza season coincides with continued COVID infx & Sxs may be confused betw both. ACIP Influenza vaccination guidelines: 1. Annual flu vaccine rec to all >6mos; 2. COVID Vax can be given w/ Flu Vax; 3. give before Nov 2021 https://t.co/oIkl50GI0W

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Dr. John Cush RheumNow ( View Tweet)

Comparing COVID vaccines in rheum dz pts - 45 took J&J vax compared to 994 on mRNA vaccines. Detectable Ab responses lower w/ J&J (80% vs 92%, p=0.03) than mRNA vax. RTX, MMF & steroids significantly depressed Ab responses https://t.co/6ZJU8EVF5n

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Dr. John Cush RheumNow ( View Tweet)

MTX impairs COVID Vax responses in IMID pts from Ehrlangen & NYU. BNT162b2 mRNA COVID-19 vaccination in rheumatic pts (82) & 206 controls. Adequate immunogenicity seen in IMID & TNFi Rx >90%, but less (50-72%) w/ MTX (45) https://t.co/EvxZSAD6ve

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Dr. John Cush RheumNow ( View Tweet)

#ClinicalPearl My pt’s rheumatoid nodules ⬇️ when she continued off her #methotrexate post #CovidVaccine. She restarted her JAKi + #plaquenil https://t.co/FqNX9k7FUN
Janet Pope Janetbirdope ( View Tweet)
In the land of a surfeit of free vaccines, this is the dark day when we crossed the line of over 100,000 hospitalizations, more than 25,000 patients in the ICU (highest for the pandemic), over 1300 deaths, and over 186,000 new cases. https://t.co/A8KNIClCwX
Eric Topol EricTopol ( View Tweet)
Given the DELTA breakthrough surge how do you feel about live medical meetings (n> 50) in the next 6 weeks @Janetbirdope @KDAO2011 @psufka @AngusWorthing @RonanTKavanagh @RheumNow @MattieRheumMD @rheum_cat @jeffsparks @hausmannMD @CCalabreseDO @DrSwamyV

Leonard Calabrese LCalabreseDO ( View Tweet)

Among pregnant women, receipt of the BNT162b2 vaccine was associated with a 78% lower risk of incident SARS-CoV-2 infection. Cohort study tincluded 15 060 pregnant women in Israel. No adverse pregnancy outcome difference in Vax Pts https://t.co/jXUjaKIfUV

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Dr. John Cush RheumNow ( View Tweet)

CDC: LA county breakthrough COVID infections: In 43,000 new COVID, 10,895, or 25.3%, occurred in fully vaccinated persons, 1,431, or 3.3%, were in partially vaccinated persons, and 30,801, or 71.4%, were in unvaccinated individuals. https://t.co/gbgaV7THch

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Dr. John Cush RheumNow ( View Tweet)

Most recent numbers from the CDC - The agency said 202,041,893 people had received at least one dose while 171,367,657 people are fully vaccinated as of Tuesday. https://t.co/3rp7QMt84y

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Dr. John Cush RheumNow ( View Tweet)

Breakthrough infections: As of Aug. 9, almost 74% of the 8,054 vaccinated people that were hospitalized with COVID-19 were above the age of 65, according to the U.S. Centers for Disease Control and Prevention. ~20% of those cases ended in deaths https://t.co/jaSmKv5pPS

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Dr. John Cush RheumNow ( View Tweet)

The CDC has reported that mRNA vaccine effectiveness against COVID-19–associated hospitalizations was sustained over 24 weeks; but there is evidence of waning protection amongst the immunosuppressed. https://t.co/UpQjFgKTpE https://t.co/3dQ2jacwJD

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Dr. John Cush RheumNow ( View Tweet)
Are you holding Otezla, SSZ, or leflunomide post vaccination? @RheumNow @LCalabreseDO @CCalabreseDO @DrDavidKarp @RADoctor @JointMD @JYazdanyMD

k dao KDAO2011 ( View Tweet)

@AngusWorthing @rheumecraig @ravenswoodrheum @JointMD @RheumNow @LCalabreseDO @CCalabreseDO @DrDavidKarp @RADoctor @JYazdanyMD @alhkim Do we have data that NSAIDS and acetaminophen alter antibody response? I would rather pts take acetaminophen or ibuprofen post-vax than prednisone.

k dao KDAO2011 ( View Tweet)

In case you missed it— Booster Shots for Rheumatology Patients on Immunosuppressive Medications https://t.co/dIzrv3B12u https://t.co/2x63osTNHh

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Dr. John Cush RheumNow ( View Tweet)
HHS, FDA & CDC Joint Recommendation on COVID Booster https://t.co/pKlFjnlQeu https://t.co/ue0pMfEvfm

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Dr. John Cush RheumNow ( View Tweet)
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