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Research presented at DDW 2024 demonstrated the superiority of guselkumab over ustekinumab or placebo in 1,021 patients with moderately to severely active Crohn's disease enrolled in the phase III GALAXI 2 and GALAXI 3 trials https://t.co/HdZf24Twsq https://t.co/REeAAskpX5

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Dr. John Cush RheumNow ( View Tweet)
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"Don't You Know Who I am?" (5.17.2024)

d Jack Cush, MD

Dr. Jack Cush reviews the news and journal reports from the past 2 weeks. This week's question: can we prevent gout, ILD or psoriasis?

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Cohort study 243 671total joint arthroplasty pts finds found no association of preoperative or postoperative colonoscopy with Periop Jt Infx risk w/ 1-yr F/U. PJI risk was incr by comorbidity (diabetes, kidney disease, and pulmonary disease). https://t.co/0J8F9YN2l2 https://t.co/USoplPPHh3

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Dr. John Cush RheumNow ( View Tweet)
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Featured BSR Abstracts (5.2.2024)

d Jack Cush, MD

Dr. Jack Cush muses on the news, journal reports, FDA announcements and the 2024 BSR abstracts just released.

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Ides of March (3.15.2024)

d Jack Cush, MD

Dr. Jack Cush has advice for Caesar and the superstitious, and covers pregnancy, platelets, dialysis and vaccinations in Lupus.

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Endoscopy and Worry are indicated in the face of DYSPEPSIA and any of these: @BCryer https://t.co/6TabKhiLPO
Dr. John Cush RheumNow ( View Tweet)
Testing for H. Pylori. Serologic tests are OK but after Rx eradication, 25% of pts will remain positive for H. Pylori. @BCryer

Dr. John Cush RheumNow ( View Tweet)

Multiple Rx options to treat H. Pylori - Dr. Cryer recs regimens of 14ds; top line w/ bismuth is most recommended. (most effective is the one the patient will actualy take!) @BCryer https://t.co/f6836Ga1Fz
Dr. John Cush RheumNow ( View Tweet)
H. Pylori is usually acquired during childhood, remains dormant until activated years later. Is assoc w/ PUD and gastric cancer, not dyspepsia. Baylor Univ Grand Round By Dr. Byron Cryer @BCryer https://t.co/KXZfigVYX9
Dr. John Cush RheumNow ( View Tweet)
Is non-alcoholic fatty liver dz assoc w/ osteoarthritis? Study of 2633 pts - 317 (12.8%) w/ OA& 1140 NAFLD(41.5%); NAFLD was positively correlated with OA (OR = 1.72; 1.26–2.34). https://t.co/whWX2XIu3d https://t.co/sGXQYSFcH3

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Dr. John Cush RheumNow ( View Tweet)
You are what you eat! So how does the Mediterranean diet affect the gut? *maintaining/shaping healthy gut microbiota *enhancing anti-inflammatory metabolite production *maintaining intestinal barrier integrity Dr. M. Guma #RNL2024 @RheumNow https://t.co/O9by7CahRW

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Dr. Rachel Tate uptoTate ( View Tweet)
How does the Mediterranean diet affect inflammation? Dr. Guma noted the diet helps to: 1. maintain healthy microbiota 2. enhance production of anti-inflammatory metabolites 3. maintain intestinal barrier integrity. #RNL2024 @rheumnow https://t.co/d3ByStvXyR

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TheDaoIndex KDAO2011 ( View Tweet)
Dr. M Guma noted @ACRheum 2022 Guidelines on RA recommend the #MediterraneanDiet; studies have shown this diet reduces CV risk, RA disease activity #RNL2024 @RheumNow https://t.co/AdKWgME4nD

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TheDaoIndex KDAO2011 ( View Tweet)
2023

2023 Rheumatology Year in Review

d Jack Cush, MD

Dr. Jack Cush reviews highlights, advances and hot topics in rheumatology from 2023 and the RheumNow website.  



2023 was a year of growth and new horizons while returning to operational and practice standards (in care and education) established before the pandemic.  

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Best of 2023: LAVLI - A New Autoinflammatory Disorder

d Jack Cush, MD

NIH researchers have have described a novel autoinflammatory disorder called "Lyn kinase-associated vasculopathy and liver fibrosis" (LAVLI), based on a mutation in the LYN gene (that encodes the Lyn kinase protein). They discovered that increased Lyn kinase activity promotes systemic inflammation, by altering microvascular permeability and neutrophil recruitment, while at the same time promoting hepatic fibrosis.

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ICYMI: SpA Sleuths: The Case of Undiagnosed IBD

d Rachel Tate, DO

Abstract #0494 provides context to our continual search for better understanding of inflammatory bowel disease in patients with AS, nr-AxSpA, and PsA.

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a bowl of yogurt with raspberries

ICYMI: Do Probiotics Improve Psoriatic Arthritis?

d Robert Chao, MD

Psoriatic arthritis and the gut microbiome have become more intertwined, especially in the past few years. It was to my amazement that one of the first abstracts I came across was the effect of probiotic modulation on gut dysbiosis and disease activity in psoriatic arthritis patients. 

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Choices

JAKi and TYK2i: What to use and when?

d Janet Pope, MD, MPH, FRCPC

You can see that the JAKi/TYK2i have both approved or potential seropositive and seronegative indications. There are also improvements in PsO for the class and studies in CTDs. So, it is difficult to know which to choose.

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OA and Microbiome! Ab#1581 @RheumNow #ACR23 Microbiome transplantation of mouse models - benefit if before or soon after OA induction (meniscal destabilization) ⭐️OA is inflammatory dis of innate immune sys, not "wear-and-tear" and gut biome may be a 🔑 https://t.co/eA8unUBnpC
Eric Dein  ( View Tweet)
TM01 @ #ACR23: Daunting Case of Diarrhea 65 yo F w/ sero+RA + 2ndary SjS p/w 4 wks diarrhea -CT a/p: thickening of cecum, ascending colon -Colonoscopy path: ischemia -R colectomy: enterocoelic lymphocytic phlebitis, no underlying vasculitis. Dx: IgG4-RD, serum IgG4⬆️ @RheumNow https://t.co/jQ57U5EjPo
Meral K. El Ramahi, MD MeralElRamahiMD ( View Tweet)

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