All News

kidneys

Beyond the Needle: Redefining the Assessment of Lupus Nephritis

Akhil Sood, MD

Lupus nephritis is one of the most silent and severe manifestations of SLE. When not captured early, patients are at high risk of progressing to end-stage renal disease, which would require dialysis or transplantation. Renal biopsy remains the gold standard for diagnosis and disease classification. However, the procedure is invasive and very painful. Non-invasive measures are critical for early detection and continuous monitoring.

Read Article
Meeting audience conference

ACR 2024 - Day 1 Report

Jack Cush, MD

ACR Convergence 2024 opened today with a full slate of presentations, posters and specialty meetings.  The meeting began with a flip: the plenary sessions started at 9AM and the poster session began at 1030 AM. Below are some of the highlights from day one in Washington, DC.

Read Article
Abstract 1686: Urinary proteomics reveals potential markers (MMP-13, M-CSF receptor, CD163, ALCAM, FOLR2) and pathways (neutrophil degranulation, ECM, tissue remodeling) involved in lupus nephritis Class II. @RheumNow #ACR24 https://t.co/kufd2zl9yc

Links:

Akhil Sood MD AkhilSoodMD ( View Tweet)
Is there a less invasive approach to evaluate lupus nephritis? Abstract 1683 highlights the potential role of 68Ga-FAPI PET imaging in evaluating for lupus nephritis. FAPI uptake ↑ in pts with lupus nephritis vs HC. Correlated with IFN -α and IFN-γ pathways. @RheumNow #ACR24

Akhil Sood MD AkhilSoodMD ( View Tweet)

Will my patient with lupus nephritis respond well to induction therapy? Abstract 1685: Aundhia et al demonstrate the promising utility of RAIL to predict complete renal response in patients with lupus nephritis (Class III or IV +/- V) @RheumNow #ACR24 https://t.co/JBldrrwUhN

Links:

Akhil Sood MD AkhilSoodMD ( View Tweet)
#1330 🔬F-Calprotectin in Early RA ➡️ New-onset RA pts(n=104) had ⬆️ F-calprotectin vs controls(n=50)(71 v. 17µg/g; p<0.001) 🔑Higher F-calprotectin linked to ⬆️ DAS28 & NSAID use ⬇️levels @ 6 months Rx ❓Role of subclinical gut inflammation in early RA #ACR24 @RheumNow

Caoilfhionn Connolly CaoilfhionnMD ( View Tweet)

Is cognitive impairment in SLE driven by cell exhaustion or aging? Abstract 1514 shows that SLE patients with cognitive impairment had higher levels of CD8+ (cell exhaustion) and lower levels of cell senescence markers. @RheumNow #ACR24 https://t.co/SzxTQt3oNY

Links:

Akhil Sood MD AkhilSoodMD ( View Tweet)
#1350 🔬 Microbiome & RA: Impact on Disease Activity & Vascular Function ➡️ Salivary microbiome a/w arterial stiffness (AIx)(p 0.019) ➡️ Stool microbiome a/w DAS28-CRP(p 0.027) 🔴Key taxa👇identified for each; no common taxa for both disease activity & AIx. #ACR24 @RheumNow https://t.co/54Sumzzd27

Links:

Caoilfhionn Connolly CaoilfhionnMD ( View Tweet)
Navigating Positive ANA: Leveraging AI for better triage Abstract 1526: Markus et al. developed a machine learning model to predict progression to SLE, utilizing diagnoses, meds, procedures, and labs collected 2 years before and 5 years after +ANA. @RheumNow #ACR24 https://t.co/2zzSH8Pb0e

Links:

Akhil Sood MD AkhilSoodMD ( View Tweet)
#1326 🔬 Predicting Imminent Inflammatory Arthritis ➡️543 anti-CCP+ at-risk (high/low) tracked 🔑Predictors for IA in high-risk: 🔴EMS≥30min(OR 11) 🔴RF+(OR 6) 🔴US PD(OR 5) 🔴smJTC (OR 5) 🔑Predictors for IA in low risk: 🔴RF+(OR 8) 🔴Anti CCP >3xULN(OR 7) #ACR24 @RheumNow https://t.co/ou9HNcNb8X

Links:

Caoilfhionn Connolly CaoilfhionnMD ( View Tweet)
Harkins @DrTrishHarkins et al. Novel diagnostic cytokines in treatment naive PMR. Elevations CXCL-9 (100%), MCP-1 (93%), IL-17A (83%), vs TNF (7%) and IL-6 (67%) @RheumNow #ACR24 Abstr#0881 https://t.co/DbYOn81QJH https://t.co/3eyre00D5d

Links:

Richard Conway RichardPAConway ( View Tweet)
The future use of a panel of immunological urinary biomarkers as a liquid biopsy for the management of lupus nephritis. Plenary Abstr#1642 @RheumNow #ACR24 https://t.co/waSRVd7FV7

Links:

Antoni Chan MD (Prof) synovialjoints ( View Tweet)
Dr @andreafava presents their noninvasive biomarker panel that predicted the probability of histologically active LN. Panel outperformed UPCR, C3, C4 & antidsDNA. Aid in clinical-decision making? Lots of potential for monitoring tx response. @Rheumnow #ACR24 abs1642 #ACRbest https://t.co/C7ZNdvbIQ7

Links:

sheila RHEUMarampa ( View Tweet)

Impressive Plenary @andreafava just finished Novel urine protein panel id 12 proteins that predict NIH activity on renal bx better than existing options Improving at 3 mos predicts response at 1 year Could reduce biopsies / modulate tx! #ACR24 @RheumNow Abstr#1642 #ACRbest https://t.co/Gi6u6hAGzj

Links:

Mike Putman EBRheum ( View Tweet)
A study presents a novel urinary biomarker panel that predicts histologically active lupus nephritis (LN) with high accuracy. Key findings: - AUC of 90% for predicting NIH Activity Index > 2, outperforming traditional biomarkers. - Identified 12 critical proteins linked to… https://t.co/6ZhqNaxpQM

Links:

Antoni Chan MD (Prof) synovialjoints ( View Tweet)

🫁RP-ILD a/w high morbidity and mortality How to Predict RP-ILD Development? ➡️AutoAb: anti-MDA5, anti-ARS, anti-Ro52 ➡️Biomarkers: CRP, LD, Ferritin, KL-6 ➡️CT: Lower consolidation/GGO #ACR24 @RheumNow https://t.co/OIrHfVTZcM

Links:

Caoilfhionn Connolly CaoilfhionnMD ( View Tweet)
This is very true. We showed a number of years ago that patients with gout have increased platelet activation at baseline, which then dramatically increases during flare. Treating gout properly may ameliorate this. #ACR24 @RheumNow https://t.co/VL8fy3ezjx https://t.co/9XdrG1NG9c

Links:

Richard Conway RichardPAConway ( View Tweet)

171 SSc pts w/ hand Xrays and US found 20% w/ Joint involvement. Active Synovitis & tenosynovitis predicted by CRP>10mg/L (p = 0.013), fibrotic tenosynovitis on US (p = 0.005), anti-RNA polymerase III antibodies (p = 0.043) https://t.co/DZrM5aQpJ7 https://t.co/CkGP6H8J6x

Links:

Dr. John Cush RheumNow ( View Tweet)
Is it pre-eclampsia or lupus nephritis flare? Abstract 0809: The sFlt-1/PlGF ratio may help distinguish preeclampsia from lupus nephritis in pregnancy. A low ratio ruled out preeclampsia, while a high ratio ± proteinuria suggests increased risk. @RheumNow #ACR24

Akhil Sood MD AkhilSoodMD ( View Tweet)

Not just the presence but higher levels of biomarkers predict RA-ILD progression. #ACR24 @RheumNow ABST#0804 https://t.co/5jhBjXDUeY

Links:

Jiha Lee JihaRheum ( View Tweet)
How well do you know this week's rheumatology news?
Take the rheumIQ quiz
Take the RheumIQ Quiz

×