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ACR 2024 - Day 1 Report

Jack Cush, MD

ACR Convergence 2024 opened today with a full slate of presentations, posters and specialty meetings.  The meeting began with a flip: the plenary sessions started at 9AM and the poster session began at 1030 AM. Below are some of the highlights from day one in Washington, DC.

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pregnant, pregnancy, mother, fertility

Is Pregnancy Truly the Solution for RA?

Eric Dein, MD

Pregnancy is perhaps the oldest treatment in rheumatoid arthritis (RA) and has been associated with a natural improvement in disease control in 50-75% of patients. Others, however, are not as successful with unchanged disease activity or worsening of their autoimmune disease.

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ACR24 Preview Podcast (11.15.2024)

Jack Cush, MD

ACR 2024 starts tomorrow. Here are a few previews of abstracts to be presented, along with my recommendations of sessions you don’t want to miss.

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obese.waist_.jpg

Weight Loss from Anti-Obesity Medications Prevents Gout

Jack Cush, MD

A population based study looked at the effect of the weight loss drug, Orlistat, in obese individuals. Compared to those untreated, orlistat over 1 year was associated with significant weight loss and significantly lower risks of incident gout and recurrent gout flares among overweight or obese people.

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Dr. Quotes (11.8.2024)

Jack Cush, MD

Dr. Jack Cush reviews the news and journal reports from this past week from RheumNow.com.

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This is very true. We showed a number of years ago that patients with gout have increased platelet activation at baseline, which then dramatically increases during flare. Treating gout properly may ameliorate this. #ACR24 @RheumNow https://t.co/VL8fy3ezjx https://t.co/9XdrG1NG9c

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Richard Conway RichardPAConway ( View Tweet)

171 SSc pts w/ hand Xrays and US found 20% w/ Joint involvement. Active Synovitis & tenosynovitis predicted by CRP>10mg/L (p = 0.013), fibrotic tenosynovitis on US (p = 0.005), anti-RNA polymerase III antibodies (p = 0.043) https://t.co/DZrM5aQpJ7 https://t.co/CkGP6H8J6x

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Dr. John Cush RheumNow ( View Tweet)
Is it pre-eclampsia or lupus nephritis flare? Abstract 0809: The sFlt-1/PlGF ratio may help distinguish preeclampsia from lupus nephritis in pregnancy. A low ratio ruled out preeclampsia, while a high ratio ± proteinuria suggests increased risk. @RheumNow #ACR24

Akhil Sood MD AkhilSoodMD ( View Tweet)

Not just the presence but higher levels of biomarkers predict RA-ILD progression. #ACR24 @RheumNow ABST#0804 https://t.co/5jhBjXDUeY

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Jiha Lee JihaRheum ( View Tweet)
High serum BAFF as a novel RF for dev't of preeclampsia in pregnant SLE pts? This study by Dr. C Sims et al showed that SLE pregnancies w/preeclampsia had significantly higher BAFF levels during the 1st trimester, and likely w/ ⬆️dsDNA or ⬇️ complement @RheumNow #ACR24 abs424 https://t.co/kNzyuT03r2

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sheila RHEUMarampa ( View Tweet)
FDA recently approved - fms-like tyrosine kinase 1 (s-Flt1) / placental growth factor (PlGF), for diagnosing preeclampsia. sFlt1:PlGF≤38 rules out preeclampsia in SLE sFlt1:PlGF>85 modestly predicts preeclampsia Proteinuria impacts prediction accuracy #ACR24 abst#0809 @RheumNow

Bella Mehta bella_mehta ( View Tweet)

Can we predict who will develop #RA-#ILD? Wheeler et al showed a combination of genetic risk score, peripheral protein #biomarkers & clinical risk factors can help identify RA-ILD in RA patients. Does this bring us closer to #PersonalisedMedicine? Ab0799 #ACR24 @RheumNow https://t.co/JZkJNGmLM1

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Mrinalini Dey DrMiniDey ( View Tweet)
Puechal et al. Serial ANCA testing may predict relapse in a large group of AAV patients but is NOT useful for individual patients. @RheumNow #ACR24 Abstr#0721 https://t.co/ClvTk2Tlar https://t.co/k4vc7l9jzK

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Richard Conway RichardPAConway ( View Tweet)
Prevalence of HLH among pts w/SLE: lower than consults would suggest! Observational study using NIS: 139 cases out of >100k pts w/SLE (0.13%); 6 fold increase in mortality Fits my priors; HLH is overdiagnosed, but bad when it happens @RheumNow #ACR24 Abstr#0619 https://t.co/iz3BlUOJb9

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Mike Putman EBRheum ( View Tweet)
Harkins @DrTrishHarkins et al. Serum disease activity markers in PMR. ROC analysis for active vs remission - fibrinogen (1.000), ESR (0.986), Haptoglobin (0.976), CRP (0.986), ALP (0.854). @RheumNow #ACR24 Abstr#0741 https://t.co/f8cX68Ov9Y https://t.co/zp5c7aQwxr

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Richard Conway RichardPAConway ( View Tweet)
#0066 🧬Epigenetics, Gut Microbiota & RA 🔬 110 RA patients v 110 controls 🦠 Collinsella abundance a/w DNA methylation changes (PRHOXNB, TBC1D22A) in RA, correlating with disease activity. 💡❔Role of gut microbiota & epigenetic markers as RA biomarkers #ACR24 @RheumNow https://t.co/yZn0KkRpE6

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Caoilfhionn Connolly CaoilfhionnMD ( View Tweet)
Another abstract #0650 highlighting the impact of tubulointerstitial inflammation predicting risk of CKD/ESRD in lupus nephritis @RheumNow #ACR24 https://t.co/XYwO0xnWNR

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Akhil Sood MD AkhilSoodMD ( View Tweet)
Which lupus nephritis patients are at higher risk for CKD? #Abstract0624 shows coexisting tubulointerstitial inflammation/damage (TII/TID) on renal biopsy is linked to CKD progression (HR 2.667, 95% CI: 1.333-5.335) Risk high among Class III, IV, V and eGFR > 30 @RheumNow #ACR24

Akhil Sood MD AkhilSoodMD ( View Tweet)

171 SSc pts w/ hand Xrays and US found 20% w/ Joint involvement. Active Synovitis & tenosynovitis predicted by CRP>10mg/L (p = 0.013), fibrotic tenosynovitis on US (p = 0.005), anti-RNA polymerase III antibodies (p = 0.043) https://t.co/OIornA9sAA https://t.co/yXyX5k2yqD

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Dr. John Cush RheumNow ( View Tweet)
An Artificial Intelligence-Based Gout Management System Reduced Chronic Kidney Disease Incident and Improves achieving Target Serum Urate levels. AI lowered incid. of CKD stage≥ 3 by 47%, & incr # achieving target SUA <6mg/dl with(59% vs 26%, p<0.001). https://t.co/INULBvaKF9 https://t.co/fkPgbscOXj

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Dr. John Cush RheumNow ( View Tweet)
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