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Is a Biomarker for Adverse Pregnancy Outcomes on the Horizon?

Bella Mehta, MBBS, MS Jun 14, 2024

With a better understanding of pathophysiology, improved management guidelines, available medications, and a multidisciplinary approach, pregnancy for lupus patients has become more feasible. Despite these improvements, some patients still experience poor outcomes, highlighting the need for biomarkers that can predict these risks. An abstract presented at #EULAR2024 (POS1393) explored this possibility.

SLE Preview: abolishing refractory with CAR-T and better B-cell therapies Despite advancements, some SLE patients remain refractory to belimumab and off-label rituximab, the main B cell-targeted therapies in the last 15 years. https://t.co/778buNUq1C https://t.co/4ub8VbrLb6

SLE Preview: abolishing refractory with CAR-T and better B-cell therapies | Rhe…

📄 You can now read my article on #CardiovascularDisease, #Stroke & #Mortality @RheumNow! 🌟 Featuring 2 cohort studies from @MayoClinic, presented at #EULAR2024 🔗 https://t.co/b639vE5hSA @MyasoedovaElena

Matters of the heart: cardiovascular disease and mortality in RA | RheumNow

#EULAR2024 OP0193 Watch out, blinatumomab will BiTE! Bi-specific T-cell engagers (BiTEs), kill Bcells by engaging Tcells. In 6 refractory #RA patients (failed 3 x ts/bDMARDs), deep blood & tissue depletion were met, good response. Brief raised temp but no cytokine storm @RheumNow https://t.co/OmxSbTXfZq

Fascinating - @ndb_org installed an app to measure smartphone usage, and texting less and moving less were associated with more flares. The pseudo-wearable in our pockets?? #EULAR2024 POS0678 @RheumNow https://t.co/ZA0hd3Q10d

https://twitter.com/drdavidliew/status/1801644214742298844/photo/1

Is muscle US useful in RA? 100+ pts 1yr followup BL muscle thickness correlated w/ grip strength improvement HAQ improv correlated w/ pennation angle vastus lateralis No diff between muscle morphology & DAS I'd say it's still easier to US joints! @RheumNow #EULAR2024 POS1033

RA patients on abatacept have an appalling immunogenic response to Shingrix. Humoral fades away in the first year, and an absence of cellular responses. Alarming and need strategies to combat this #EULAR2024 POS0620 Winthrop/@RADoctor @RheumNow https://t.co/8gY9ocLBDp

https://twitter.com/drdavidliew/status/1801641070629109908/photo/1

If your GCA flares, do you get the same features as you did at diagnosis? 20% of the time it can be new, so keep on doing the checklist! (also, visual flares uncommon - the power of pred) #EULAR2024 POS0110 @MayoClinic @MdWarrington @RheumNow https://t.co/hkF8vJT6HI

#EULAR2024 POS0390 What impact of regulatory warning on JAK-i on access to therapy? Data from UK BSSR-BR reported 4 in 5 #RA patients would have been considered ‘high-risk’. Of these, 28% had failed ≥3 biologics; so no suitable alternatives. Enormously impacted @RheumNow https://t.co/XeS9qHXSpH

https://twitter.com/Yuz6Yusof/status/1801634766610964984/photo/1

What psychosocial factors drive treatment outcomes and disease activity for people living with rheumatoid arthritis? #EULAR2024 POS0309-PARE @DrMiniDey @ElenaNikiUK @RheumNow https://t.co/q0tTLSL044

https://twitter.com/drdavidliew/status/1801634187000299677/photo/1

Join me on @RheumNow at 6pm this evening here in Vienna to hear about the roundup from today at #EULAR2024

Do we give enough attention to pts mental health? 2 cohort 400+ RA tREACH & DEPAR 500+ PsA RA 20% depression 30% anxiety PsA 19% depression 22% anxiety 2 yrs no remission RA OR 2.5 depression OR 1.7 anxiety PsA OR 6.10 depression OR 4.67 anxiety @RheumNow #EULAR2024 POS0946 https://t.co/ok4HRNJqgY

https://twitter.com/AurelieRheumo/status/1801624630626484634/photo/1

Fantastic long COVID debate: close friends Xavier Mariette & @LCalabreseDO head-to-head, debating whether long COVID is a specific disease or part of fibromyalgia. Xavier argues it looks like any post-viral syndrome, & the immunological signal isn’t there. #EULAR2024 @RheumNow https://t.co/ajKjBSRo2n

#opportunistic inf in #autoimmune dz 🎤 @khyrich 👉#herpes zost is ⬆️⬆️,esp😳#lupus (💉 >18yo🇺🇸) 👉#HBV react ⬆️⬆️ w/ RTX (9.1%) >>TNFi, JAKi, IL-6 👉 🙅‍♂️ #TB repeat 🧪 on #DMARD if 🚫new risk fact/gap⚠️ 🔗#eular 2022 guide: https://t.co/PIpGpTrH28 #eular2024 #rheumx @RheumNow https://t.co/kouXvradiC

How good are we at picking up depressing in RA patients? In this Polish registry: - 1.8% had a depression diagnosis - 21% had low mood on HAQ & depression has real correlates with disease activity. Plenty to think about with truly holistic RA care! #EULAR2024 POS1045 @RheumNow https://t.co/ZNbMVo8TGk

https://twitter.com/drdavidliew/status/1801600138252517568/photo/1

Just a reminder - large vessel involvement is very common in GCA, and lines up with aortic dilatation. And if you don’t look, you won’t find… #EULAR2024 POS0932 @RheumNow https://t.co/2uZTu0B18Z

https://twitter.com/drdavidliew/status/1801599623754105192/photo/1

Bold conclusion from Japan: laughter improves function in RA. I like it Feel like it might be partially a correlation/causation link but if an hour of laughter can push down IL-6 levels in RA patients, time for reimbursement for stand up comedy? #EULAR2024 POS1029 @RheumNow https://t.co/EpHnX50PgF

Interpreting Hepatis B serology results. Hyrich K #EULAR2024 @RheumNow https://t.co/boXw2XCI2m

https://twitter.com/synovialjoints/status/1801597256245616877/photo/1

Approach to TB screening prior to commencing biologics. Hyrich K #EULAR2024 @RheumNow https://t.co/j3PI0PHpqW

https://twitter.com/synovialjoints/status/1801596567758967036/photo/1

New imaging technique PET/CT imaging with 68Gallium-labelled Fibroblast Activation Protein Inhibitor-04 (68Ga-FAPI-04) enables the visualization of fibroblast activation in vivo. No correlations with MSUS findings were found. Fibroblast activation detected by 68Ga-FAPI-04-PET/CT… https://t.co/4VTF1YDzYd https://t.co/Y8Hmlf3sWl

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Is a Biomarker for Adverse Pregnancy Outcomes on the Horizon?

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