RheumNow Week in Review – 5 August 2016

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Highlights from this week on RheumNow.com include:

1. Having #RA in addition to solid cancer (breast, lung, prostate, colon) increases mortality rates by 40-50% in elders https://t.co/aitjusmOai
2. The global market for rheumatoid arthritis therapies was $19.9 billion in 2015, expected to reach $21.3B by 2020 https://t.co/d2Sh5C8y9f
3. Half of doctors never heard of MACRA:Medicare Access & CHIP Reauthorization Act. Starts on Jan 1st! https://t.co/eYgWBWCw6y Blog:https://t.co/sRKZSOFyNV

And more!

RheumNow Week in Review - 29 July 2016

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Dr Jack Cush reviews this week's highlights from RheumNow.com.

RheumNow Week in Review – 22 July 2016

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From tofacitinib developmental trials in RA and psoriasis and adherence to T2T in early RA to a rheumatology pearl about dapsone and much more, here are the highlights of what you may have missed on RheumNow.com this week.

SAPHO Syndrome Revisted

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SAPHO is an acronym that describes a constellation of findings (synovitis, acne, pustulosis, hyperostosis, and osteitis) that defines this rare syndrome. 

Lupus Patients Genomically Stratified to Explain Treatment Responses

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Systemic lupus is a clinically heterogeneous disorder, unified by requisite clinical features and exuberant humoral response to unknown triggers.  While the diagnosis is easy, the disease course and management can be complicated and challenging.  

Early DMARD Therapy Averts Cardiovascular Risk in RA

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A Finnish early RA register studied 14,878 incident RA patients from 2000-2008 and identified 1157 deaths. Patients receiving DMARDs and MTX had lower mortality rates. The standardized mortality ratio for the entire cohort was reduced (0.57, 95% CI 0.52 to 0.62).

New EULAR Guidelines on Behçet's

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At the EULAR 2016 meeting, new EULAR recommendations for the management of Behçet's disease (BD) were presented.

EULAR 2016 Drug Safety Report

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The EULAR Annual European Congress of Rheumatology meeting was held in London from June 8-11, 2016 and was well attended by thousands. This year’s meeting had over 2,000 poster displays, and the EULAR 2016 Congress presented new recommendations on the management of rheumatoid arthritis, spondyloarthritis, and fibromyalgia.

GiACTA Study Shows Benefit of Adding Tocilizumab to Steroid Taper in Giant Cell Arteritis

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The GiACTA study has published its top line results demonstrating the efficacy of adding tocilizumab (TCZ) to steroid-tapered therapy in patients with giant cell arteritis (GCA). 

Risk of Steroid-Induced Diabetes Quantified

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Glucocorticoid (or steroid) therapy is a well-known risk factor for diabetes. But what dose, given how and for how long?  Dixon and colleagues from the The University of Manchester have quantified the risk of diabetes associated with steroid use.

Lupus Patients Genomically Stratified to Explain Treatment Responses

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Systemic lupus is a clinically heterogeneous disorder, unified by requisite clinical features and exuberant humoral response to unknown triggers.  While the diagnosis is easy, the disease course and management can be complicated and challenging.  

Tocilizumab Induces and Maintains Remission in Giant Cell Arteritis

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Lancet has reported the results of a randomized, double-blind, placebo-controlled trial of tocilizumab in patients with new-onset giant cell arteritis (GCA).

Oral Prednisolone and NSAIDs Equipotent in Acute Gout

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An emergency department based study evaluated the efficacy and safety of oral prednisolone versus indomethacin in 416 patients with acute gout in a multicenter, double-blind, randomized trial.

Steroid Over-Prescribing Persists in RA

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Almost half of patients with rheumatoid arthritis (RA) in the UK receive glucocorticoids from primary care physicians, and of those who are prescribed glucocorticoids, more than half receive more than 10 mg a day.

Ominous Outcomes for Lupus Nephritis

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Hanly and coworkers have reported the results of a large lupus cohort study involving 1827 patients. SLE patients were enrolled early in their disease (0.5 years) and were followed for a mean of 4.6 years.

Epidural Steroid Injections Ineffective

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A meta-analysis of 30 placebo-controlled trials evaluated epidural corticosteroid injections for radiculopathy, and 8 trials were done for spinal stenosis.

2015 Guidelines for Idiopathic Pulmonary Fibrosis

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Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrosing form of interstitial pneumonia, with poor survival rates of nearly 50% at 3 years.

Intraarticular Hip Injection of Ketorolac Equals Steroid Responses

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Using ultrasound guided intraarticular injection of the hip, 98 OA of the hip patients were randomized to receive IA ketorolac or triamcinolone. At, 1, 3, and 6 mos pain scale and Harris hip scores were improved equally in both groups with no statistical differences.

Safety Reports & Updates – May 2015

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Men are Less Likely to be Screened for Osteoporosis

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Study by Dashkova et al finds males less likely to have their bone density checked, but suffered worse outcomes. "We were surprised at how big a difference we found between men and women regarding osteoporosis," study author Dr.