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The RheumNow faculty reporters have been scouring and reporting on the best abstracts from the ACR. Here is a sampling of their choice abstract presentations reported during ACR 2020 Day 2 (#ACRbest).
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The opening of ACR2 Convergence was a hit for all who signed up and viewed in. The day included the presidential address by outgoing president Dr. David Karp (UT Southwestern) and a keynote talk and interview with Dr. Seema Yasmin (Stanford).
Robert B Chao, MD
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⭐️AxSpA pts with decrease in oral microbial diversity
⭐️Immune response to oral/fecal microbes altered in AxSpA pts.
⭐️HLA-B27 associated ⬆️IgA coated microbes, may contribute to development of AxSpA
Abs#0052
https://t.co/NQgm0lpYJj
#ACR21
@RheumNow
Richard Conway
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Dr Preger report 9 novel aminoacyl tRNA synthetases in IIM patients. May these allow us to spare more patients biopsy? Abstr#0001 #ACR21 @RheumNow https://t.co/ikNXCEOeuj
David Liew
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apart from that, fibrosis is fascinating - as is the potential for a shared fibrotic pathway
#ACR21 Antifibrotics session @RheumNow https://t.co/FXbhBx9sJ1
Pedro Castillo
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BAFF & APRIL support B cell development, diff, survival.
ALPN-303: Antagonist of both BAFF & APRIL
💠⬇️B cell fxn & Ab production,⬇️Plasma cells
💠⬇️UProt, dsDNA, renal immune complexes (mouse model)
💠Pending human studies
https://t.co/kzVpUDuNWs
#ACR21 Abst#1429 @RheumNow
TheDaoIndex
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Novel way to treat inflammatory arthritis!
A bioengineered probiotic bacterium, L. reuteri (LrS235) was found effective to reduce inflammation and clinical signs of inflammation in rats with inflammatory arthritis.
Abst # 1707 #ACR21 @rheumnow https://t.co/UC28yRlGYP
Meral K. El Ramahi, MD
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Wager question that cemented the winners: @UTMB:
⭐️This monogenic disease can mimic Behcet's & occurs d/t mutat in TNFAIP3.
➡️Haploinsufficiency A20
Congrats to the winners & all contestants, including the top 2 finalists: @MGHrheumatology & @EmoryUniversity!
#ACR21 @RheumNow https://t.co/LZqsBKiPL8
Aurelie Najm
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Anti-NETs antibodies in #COVID.
1️⃣ correlate➖ w/ SpO2/FiO2 ratio (IgG r=-0.17 IgM r=-0.30
2️⃣correlate➕ w/ ⬆️D-dimer (IgG r=0.33 IgM r=0.19
3️⃣ ⬆️ in pts requiring MV
In a study of 328 pts. Probably driving complement activation!
#ACR21 #Abst1430 @RheumNow https://t.co/2MCrLueTzN
Akhil Sood MD
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Wonderful interview @KDAO2011 and @alhkim with great learning points on #BCell #Immunology
#ACR21 @RheumNow https://t.co/1292FNZanL
Eric Dein
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#ACR21 Abs:#1429: ALPN-303: Dual BAFF/APRIL antagonist for SLE:
⭐️Encouraging immunomodulatory activity and efficacy in animal models. ⬇️ Plasma cells and Ig secretions in vitro & vivo
⭐️Well-tolerated in animals w/o adverse events
🔥Phase 1 study in healthy volunteers!
@Rheumnow
Meral K. El Ramahi, MD
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Abst#0572: In US veterans w/ RA followed for 17 yrs, several cytokines+chemokines
⭐️Associated w/ ↑ risk of incident MACE independent of typical CVD RF & RA activity
&
⭐️Predicted MACE even if in LDA/remission
WOW! We need to do better @ CVD risk strat!
#ACRBest @RheumNow https://t.co/J74rRa9EQE
Meral K. El Ramahi, MD
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⭐️RA pts w/ high adipokines (fat-secreted proteins) have lower rates of LDA + remission independent of b/l dz activity & BMI
⭐️↑ adipokines esp adiponectin, then more likely to need b/tsDMARD
➡️Adipokines may be prognostic biomarkers 4 refractory dz.
Abst#0789 #ACR21 @RheumNow https://t.co/AFT22TzTFp
Leonard Calabrese
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#ACR21 Ignaki Sanz makes the case that +++ AUTOANTIBODIES are integrally involved in #COVID19 immunopathogeneisis and may rise and fall w disease states- TBD what role they play in acute disease and #LongCovid @CCalabreseDO @VirusesImmunity @CleClinicMD #COVID19AB https://t.co/9dzCSh5V7R
TheDaoIndex
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The future according to Dr. M Brenner?
👉Bioengineered cells to treat inflammation.👈
#BasicScience #YearInReview #ACR21 @rheumnow https://t.co/EgoYBEZgT0
Chris Wincup
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And I’m finally in the game!! On board for #ACR21
Enjoying hearing Virginia Pascal showing data on how opsonisation of red blood cells containing mitochondria results in the induction of Type I Interferon pathways
Great paper here https://t.co/QWJLncYmC3 #ACRambassador
Looms4Lupus
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#ACR21 - Dr. Virginia Pascual speaking on #PrecisionMedicine in Lupus. Mitochondria in RBC's will cause more disease activity in Lupus patients. Th groups that remove Mitochondria have less disease activity. Hope this takes us to #precisionmedicine soon!. #Looms4Lupus https://t.co/sMOmeJPMJX
Akhil Sood MD
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Abst 0501
Kakkar & colleagues examined immunogenicity of single dose of SARS-CoV-2 Vaccine in patients with systemic sclerosis
- Vaccine is safe
- Immunosuppression lowered Ab production but no effect on T cell response
#ACR21 @RheumNow https://t.co/NsLrWHh7ZS
David Liew
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In GCA, why might you target GM-CSF over IL-6?
Entirely plausible TCZ might be leaving some Th1 stones unturned, esp:
vascular remodelling
downreg pathways
Transcriptomics from toci/mavri-treated TAB show it's plausible beyond just theory...
Cid group #ACR21 ABST0506 @RheumNow https://t.co/YephlzHOdj
Dr. John Cush
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IL-18 in autoinflammatory Disorders session talk by Raphaela Goldbach-Mansky
- Discovered in 1995
- IL18 expressed in epithelial cells, keratinocyts, macrophages
- IL-18R neg regulated by IL-18 binding protein
https://t.co/U6TTDqEb7L https://t.co/R2lIo188ac
