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A systematic review of the effectiveness and safety of pharmacological treatments for adult-onset Still’s disease (AOSD) supports the use of either IL-1 or IL-6 inhibitors.
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An international cohort of children with systemic Juvenile idiopathic arthritis (Still's disease) validated the systemic Juvenile Arthritis Disease Activity Score 10 (sJADAS10), a disease activity measure distinguish patients with inactive disease, minimal disease activity, moderate disease activity, and high disease activity.
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A metanalysis shows that social determinants of health adversely impacts patients with lupus nephritis. Lupus nephritis is a significant complication of SLE, often with dramatic increases in morbid and mortal risks. Outcomes are likely to be augmented by social determinants of health, including socio-economic status, and social risk factors.
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Positive findings with color Doppler ultrasound were enough to diagnose giant cell arteritis (GCA) accurately without need for confirmation with temporal artery biopsy (TAB), a prospective study indicated.
Dr. John Cush
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Featured BSR Abstracts
Dr. Jack Cush muses on the news, journal reports, FDA announcements and the 2024 BSR abstracts just released.
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Lower Limb Muscle Mass Influences Osteoarthritis Risk
The Rotterdam study shows that weight-bearing recreational physical activity caused more incident knee osteoarthritis (KOA), but mainly when there was low muscle mass.
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Study of 187 Oligoarticular JIA pts - Remission was achieved w/ DMARDs in 65.8%; predictors of nonresponse (DMARD resistance) - Elevated CRP (> 1.1 mg/dL' OR 1.3) & and high JADAS-71 at Dx (> 15.8; OR 1.7) https://t.co/tuO7UsEfrL https://t.co/KGcdBtneQt
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French insurance claims study of 12071 #PsA pts on biologics (2015-2021) found total of 367 serious infections (3%; IR 1.7/100PY). SIR risk significantly lower for new users of etanercept (wHR 0.72) & ustekinumab (wHR 0.57) (vs ADA new users https://t.co/CutqoxA05e https://t.co/OUCUbrKnFF
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Long term F/U of T2T in BeST (early RA 153) & IMPROVED (UA 282) pts 12 & 20 yrs after, the majority of RA & UA pts were in DAS remission (91% LDAS, 68% remission), & w/ limited functional disability (mean HAQ 0.6-0.8). Xray progression was mild https://t.co/vcL8Mnv0Ty https://t.co/lPVbNipFng
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#BSR Analysis of 1,362 pts starting 1st JAKi before EMA warnings on JAKi (1/23) showed 28% prev failed ≥3 bDMARDs & 80% met ≥1 EMA JAKi risk criteria -that included 1) age ≥65 2) incr CV risk; 3) current/past smoker; 4) prior cancer https://t.co/U3IaswZUyy https://t.co/m43RDAbpwP
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Machine learning analysis of retrosp EHR data (3/20-9/22) on 2+ million showed COVID (5.3%) outcomes in #IMID pts not linked to DMARD or IMID Dx; but rather to age, unvaccinated, & comorbidities (Afib, CAD, CHF, CKD, COPD, CA, liver Dz) https://t.co/aMmJD5P9cc https://t.co/Yy9FuCvol4
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SLE Faculty Panel Q&A
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Complex Autoantibody Patterns in RA
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Dr. John Cush
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NEJM: evolution of pyoderma gangrenosum skin lesions https://t.co/vsgQhsjY5q https://t.co/INrbTIc9kX
Dr. John Cush
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Systemic Inflammation and Mortality in RA-ILD
Analysis of the German RABBIT registry shows that systemic inflammation, more so than disease activity, strongly influences all-cause mortality in patients with RA-ILD.
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In 530 #GCA pts, relapses seen in 46%; but severe relapse (ischemi/aortic events) in 3%. Severe GCA relapse pts more likely to be younger at Dx(P=0.02), w/ more limb claudication(< 0.0001), fewer GCA-related cranial Sxs (<0.0001); but not higher mortality https://t.co/k7wgU6oMcn https://t.co/BKOfGmZ27u
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FDA issued a drug safety warning linking thiopurine (AZA, 6MP) use in pregnancy & a rare risk of intrahepatic cholestasis of pregnancy (ICP). ICP has been reported in pts w/ CD, UC, or SLE; however thiopurines are not FDA approved for these Dx https://t.co/s37eRuAtQx
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Study of f 234 AAV pts. 85 (36%) developed diffuse alveolar haemorrhage. Independent predictors of DAH: 1) Age [OR=1.037); 2) PLT # [OR=0.996]; 3) ESR [OR=1.028]; 4) HgB [OR=0.978]; 5) hematuria [OR=3.77] https://t.co/shI8RPZgcv https://t.co/dmceGvUuyR
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Biomarker Predictors of Osteoarthritis
Science Advances has reported that Duke University researchers have validated a biomarkers of osteoarthritis that may be identified 2 years before the appearance of radiographic OA. S
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Dr. John Cush
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Very late onset Lupus (>60) is less female, less arthritis/dz activity, lower dsDNA, C3, SSA, SSB and ANA but more Sjogrens & RA? Single clinic study of 845 SLE - jSLE (<18), aSLE (18-49), lSLE (50-60), and vlSLE (>60).vlSLE had lowest survival (20yrs) https://t.co/VwDSArDhrc https://t.co/3pSr0xSCKn
