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ICYMI: Our old friend, hydroxychloroquine

d Eric Dein, MD

After an action packed weekend, RheumNow Live 2023 concluded on Sunday with a half-day session on systemic lupus erythematous and ankylosing spondylitis discussing many new medications that are revolutionizing rheumatology. Dr. Laurent Arnaud, a professor at Strasbourg University in France, however, took the time to review one of our oldest therapies: hydroxychloroquine.

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Disappointing Secondary Use of Newer Therapies in Psoriatic Arthritis

d Jack Cush, MD

Analysis of patient data from five Nordic registries shows that the uptake of newer biologic or targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs) in psoriatic arthritis (PsA) was mainly in biologic-experienced patients.

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Proposed AOSD criteria: 80 AOSD vs 60 autoimmune pts: \Nneed 7 points = AOSD dx (sensitivity 92%, specificity 93%, AUC 93%): - typical rash 3 pts - fever ≥ 39°C 3 pts - pharyngitis 2 pts - arthritis 2 pts - glycosylated ferritin≤ 20% 1 pt https://t.co/iLUryBVa7C https://t.co/HTWgAucBIm

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Dr. John Cush RheumNow ( View Tweet)
2022 EULAR Recommendations on Screening and Prophylaxis for Opportunistic Infections Opportunistic and chronic infections may be rare and are often difficult to diagnose, especially in patients with AIIRD, that may be immunocompromised. https://t.co/eAN3X3kAHV https://t.co/qpFc7hlG7u

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Dr. John Cush RheumNow ( View Tweet)
Low Risk of Venous Thromboembolism with IVIG and Dermatomyositis A cohort study analyzed the risk of venous thromboembolism (VTE) in dermatomyositis (DM) patients treated with intravenous immunoglobulin (IVIG). https://t.co/tYOwsNaiGy https://t.co/Bpfft4J9MB

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Dr. John Cush RheumNow ( View Tweet)
Heart to Heart: Cardiovascular Risk in RA Tune in as Dr. Christina Charles-Schoeman and Dr. Roy Fleischmann discuss how to help mitigate CVD risk in patients with RA in the latest therapeutic update sponsored by AbbVie US Medical Affairs. https://t.co/52g6cnI5Wi https://t.co/E87OUHWFib

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Dr. John Cush RheumNow ( View Tweet)
Comprehensive full read review of Cutaneous Lupus Erythematosus - pathogenesis, pathology and treatment options. https://t.co/J7C0511kBJ https://t.co/ILhcpeT5cx

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Dr. John Cush RheumNow ( View Tweet)
Pregnancy in PsA RheumNow Live 2023: Christina Chambers, PhD, MPH, University of California, San Diego School of Medicine https://t.co/QR0Mb7F1x3 https://t.co/rj6HtoUTpE

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Dr. John Cush RheumNow ( View Tweet)
JAK inhibitors in Psoriasis and PsA RheumNow Live 2023: Eric Ruderman, MD, Northwestern University, Feinberg School of Medicine https://t.co/eVwQ6ITzD7 https://t.co/GZxVx77aV1

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Dr. John Cush RheumNow ( View Tweet)
B-Cell Stimulating Factors Tied to Lymphoma in Sjogren's Genetic blood tests indicated that BTK and a cytokine called APRIL were overexpressed in patients with primary Sjögren's syndrome who subsequently developed lymphoma, French researchers reported. https://t.co/DMsjFzmjPn https://t.co/X1fg9ylo7g

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Dr. John Cush RheumNow ( View Tweet)
Study of 481 incident RA: - no risk of RA w/ tea, alcohol & sugar-soft drinks - Incr RA risk seen w/ coffee [≥4 vs ≤1cup, HR=1.24;p=0.04] & diet drinks [HR=1.66;never-smokers] - Reduced RA risk w/ mod EtOH (ever-smokers;HR=0.63) & wine (seropos RA) https://t.co/RQFpxXUT11 https://t.co/ew2imYMLnJ

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Dr. John Cush RheumNow ( View Tweet)
Tuesday Night Rheumatology: POD 3: Vasculitis: Evolution and Advances This webinar will feature highlights from these lectures followed by live audience Q & A: -New Therapies for PMR & GCA -Assessment of GCA and PMR -GPA Treatment Choices https://t.co/PRj6QQnxIS https://t.co/Y4aCyTrg0Z

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Dr. John Cush RheumNow ( View Tweet)
One in Ten has Autoimmune Disease A UK population-based study suggests that autoimmune diseases affect approximately one in ten individuals. https://t.co/a2VbAO0Fc6 https://t.co/69Yl9OTtKY

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Dr. John Cush RheumNow ( View Tweet)
Does King Charles have Sausage Digits (dactylitis) or OA? https://t.co/Wg3JaTAGf1 https://t.co/Wg3JaTAGf1 https://t.co/iAHfYbZD7t

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Dr. John Cush RheumNow ( View Tweet)
REMIT-UC: Tofacitinib study 334 w/ Ulcerative Colitis:Clinical remission in 35%, Endoscopic remission in ~24%; & low risk (per/100PY) of serious infections (2.1), H zoster (0.5), & VTE (1.1). Loss of response in 45%, but recaptured 55% w/ dose escalation https://t.co/KgSrKBbv40 https://t.co/M74l4tOA3U

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Dr. John Cush RheumNow ( View Tweet)
Heart to Heart: Cardiovascular Risk in RA Tune in to hear experts discuss cardiovascular risk assessment, patient education, and the importance of disease control in the latest therapeutic update sponsored by AbbVie US Medical Affairs. https://t.co/Tz8VBiXhwt https://t.co/EQ0dRmM27r

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Dr. John Cush RheumNow ( View Tweet)
When Hannah Glick receives her M.D. this week, she will join her mother, Dr. Rachel Glick, and grandmother, Dr. Marilyn Heins, as the only family in the U.S. with three generations of women doctors that are living, according to @AAMCtoday. https://t.co/AzRw2I4CU8 #GoBlueMed https://t.co/0tgMwVLwxF

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University of Michigan Medical School UMichMedSchool ( View Tweet)
View an interactive disease modification patient journey from the #LupusEducatorsNetwork and learn about the importance of helping to prevent renal damage in your patients with #LupusNephritis. #SponsoredbyGSKUSMA https://t.co/XKG25eVSfa https://t.co/Jbo2iR6OuJ

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Dr. John Cush RheumNow ( View Tweet)
2010 Colchicine Price Hikes Adversely Affected Gout Care Research shows that the large increase in colchicine cost in 2010 was associated with an immediate decrease in colchicine prescription use,. https://t.co/WS721SlM6p https://t.co/BBdqDVGolq

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Dr. John Cush RheumNow ( View Tweet)

Orphan drugs target rare dz <200k. New drugs (2008-2016) compared 5 yr sales 86 orphan Rx to 232 non-orphan = similar sales- Orphan ($719 mill) vs nonorphan ($812 mill). But orphan Rx lower volume offset by higher prices (7X higher) than nonorphan drugs https://t.co/I8kb4A0eyG https://t.co/gEQpssRVkg

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Dr. John Cush RheumNow ( View Tweet)
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