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Scleroderma Raynaud's May Worsen in Summer

MedPage Today

Episodes of Raynaud's phenomenon, a common feature of systemic sclerosis (SSc, also known as scleroderma), were more severe not only at low temperatures, as one would expect, but also during summertime heat, a multinational study found.

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Sustained Hydroxychloroquine and Cardiovascular Outcomes

Jack Cush, MD

A national cohort study shows that continuous use of hydroxychloroquine (HCQ) protects agains cardiovascular (CV) events in patients with systemic lupus erythematosus (SLE).

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Running with Data (8.30.2024)

Jack Cush, MD

Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow.com - including tips on steroids, MAS, and myositis testing.

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BCP,OCP

Birth Control Use in Lupus

MedPage Today

Published guidelines on lupus management urge that female patients plan and prepare carefully for pregnancy, and use contraceptives when it's not intended -- but these recommendations are only rarely followed, a registry study suggested.

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All in the Family (8.23.2024)

Jack Cush, MD

Dr. Jack Cush picks highlight reports from the past week on RheumNow.com, with reports on the challenge of lupus nephritis, perplexing skin issues, you don't know JAK (about Tyk) and the value of a good family history.

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Predictors of Pregnancy Outcomes in Systemic Lupus Erythematosus

Jack Cush, MD

A systematic review of preconception predictors of pregnancy outcomes in women with systemic lupus erythematosus (SLE) highlighted lupus nephritis, chronic hypertension, SLE disease activity and secondary antiphospholipid syndrome as predictors of adverse pregnancy outcomes. Pregnancies in women with SLE have historically been described as challenging, both because of the risk of disease flare and of adverse pregnancy outcomes.

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Metanalysis of Social determinants of health and lupus nephritis (31 studies) showed poor LN outcomes were 1.47-fold higher w/ any adverse SDoH. Also multiplicative impact of having two or more adverse SDoH on LN outcomes. https://t.co/4oEuAEgBx1 https://t.co/OkeRzrCXzQ

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Dr. John Cush RheumNow ( View Tweet)
Life Essential 8 (LE8) score studied in RA & SLE was neg. corrlated w/ DAS28 (r −0.96) & SLEDAI (r − 0.81) & assoc w/ 10 yr survival. LE8 score: smoking, sleep, physical activity, diet, BMI, non-HDL, BP, fasting glucose, & HgbA1c. https://t.co/DCpWKzmt80 https://t.co/eKqqEO1F65

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Dr. John Cush RheumNow ( View Tweet)
Retrospective observational study of 96 stable #SLE pts compared maintenance on HCQ vs belimumab. There were no significant differences in Flare rate (18% HCQ vs 8.3% BLM; p=0.47), damage index increase, SLEDAI, Pred dose or adverse events https://t.co/sVPMugSHn3 https://t.co/6bdel6Kvs9

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Dr. John Cush RheumNow ( View Tweet)
Birth Control Use in Lupus Published guidelines on lupus mgmt urge that female patients plan and prepare carefully for pregnancy, and use contraceptives when it's not intended -- but these reco’s are rarely followed, a registry study suggested. https://t.co/81mQbp5Sib https://t.co/NJmwxvtR44

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Dr. John Cush RheumNow ( View Tweet)
ANA's over time may be more dynamic than previously accepted. SLE & ANA+associated Dz tend to have higher titers, esp. higher in early disease, but decrease over time https://t.co/caUazl9U6S https://t.co/jBglFBJ886

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Dr. John Cush RheumNow ( View Tweet)
Retrospective study of 58 pts w/ #SLE concurrent with PJP infx, showed that 39% died, with many of these having diabetes and invasive ventilation. A 4 fold incr Mortality seen risk factorsHyperglycemia/DM, decreased C3, & thrombocytopenia https://t.co/CqPpRXG8mN https://t.co/GyKbiU8GWY

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Dr. John Cush RheumNow ( View Tweet)
All in the Family (8.23.2024) Dr. Jack Cush picks highlight reports from the past week on RheumNow, with reports on the challenge of lupus nephritis, perplexing skin issues, you don't know JAK (about Tyk) and the value of a good family history. https://t.co/gwM77mJCnr https://t.co/HOGnymjhSZ

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Dr. John Cush RheumNow ( View Tweet)
Causes of Carpal Tunnel Syndr: obesity, repetitive wrist movements, pregnancy, RA, PsA. but also Sjögren's syndrome, Behcet's disease and systemic sclerosis (weaker) https://t.co/ssrs8UJEpX

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Dr. John Cush RheumNow ( View Tweet)

Sequential Belimumab and RTX in SLE Could disease control in active SLE patients be improved by the sequential use of subcutaneous BEL and intravenous RTX? A double blind trial has shown that sequential BEL and RTX was not superior to BEL alone in SLE. https://t.co/CO0ltRX9Eo https://t.co/zey2UE4BRu

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Dr. John Cush RheumNow ( View Tweet)
Predictors of Pregnancy Outcomes in SLE A review of preconception predictors of pregnancy outcomes in women with SLE highlighted lupus nephritis,chronic hypertension, SLE disease activity and secondary antiphospholipid syndrome as predictors of APO. https://t.co/vA445kSe5t https://t.co/wGhLjCmJ3v

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Dr. John Cush RheumNow ( View Tweet)
100 top-cited studies in #SLE. 60% from USA; half focused on underlying mechanisms #1 1982 1982 Revised Criteria for.. Classification ..SLE #2 Updated ACR Criteria... #3 Derivation of SLEDAI https://t.co/g3fcUqtsct https://t.co/HlGfGC4aci

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Dr. John Cush RheumNow ( View Tweet)
🔥 One of the most important articles of the year showing medical evidence for disease-modifying (organ damage prevention) therapies in #SLE #lupus: CLICK 👉 https://t.co/Qmia9Gc8mu Kudos to the authors for such an important piece of work. Open up the table in the article and… https://t.co/z9osFAavud https://t.co/lWjkwMEHrq

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Donald Thomas, MD lupuscyclopedia ( View Tweet)
Metanalysis of 50 RCTs (3,231 pts w/ lupus nephritis (LN) related starting pred dose to rates of complete response (CR), serious infections, & death. PO pred 25 mg/D assoc w/ 20%, 3.2% & 0.2%, respectively. Pred 60 mg/day incr rates to 35%, 12% & 2.7% https://t.co/6FH9BWsmaz https://t.co/0cQPAIuvRw

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Dr. John Cush RheumNow ( View Tweet)
Pregnancy, menopause, contraceptives, hormone replacement, aromatase inhibitors may affect lupus outcomes. Review says hormone therapies are contraindicated w/ antiphospholipid syndr, APL Ab positivity, and uncontrolled SLE or flares https://t.co/bZQr8b871n https://t.co/OmXY04GR4p

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Dr. John Cush RheumNow ( View Tweet)
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