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“Rheumatic diseases - diseases of accelerated aging”
With age:
⚖️ fat ⬆️
💪🏻 muscle ⬇️
👉 results in ⬇️fn ⬇️gait speed ⬇️grip
🌟what can we do?
⚡️start with basic diet and exercise advice
✅caloric restriction (⬇️350cal/day)
✅ resistance training
#GeriRheum #ACR22 https://t.co/6KRrwCWBEZ
Patricia Harkins DrTrishHarkins ( View Tweet)
Botson et al. 52 week results MIRROR trial. MTX added to pegloticase. 71% vs 39% SU <6mg/dl. Infusion reaction 13% vs 32% if ab+ 0% vs 30% ab- @RheumNow #ACR22 Abstr#0001 #ACRbest https://t.co/1c3Va9NxNX https://t.co/dPGDyWue4G
Richard Conway RichardPAConway ( View Tweet)
England et al. Influence of FVC on choice of b/tsDMARD in RA-ILD. FVC predicts hospitalisation and mortality. However, it did not appear to influence choice of b/tsDMARD. Overall 67% of RA-ILD patients initiated TNFi, weird! @rheumnow #ACR22 Abstr#245 https://t.co/swuNHv96WD https://t.co/vy5FUPnNjo
Richard Conway RichardPAConway ( View Tweet)
Interesting observation: Late-onset PsA assoc'd w/ male sex, greater structural damage, higher frequency of arthritis, and greater loss of functionality (BASFI). Interestingly, shorter time of symptom duration to dx. Abs 0377 #ACR22 @RheumNow https://t.co/m15c37FltD https://t.co/3LRy4Ltde6
Dr. Rachel Tate uptoTate ( View Tweet)
#ClinicalPearl #Methotrexate is recommended for Rx in all EXCEPT…#ACR22 @RheumNow
Janet Pope Janetbirdope ( View Tweet)
Difficult to treat #rheumatoidarthritis - phenotypes need to be defined and order of Rx may be v Impt. Well, it is really difficult @RheumNow #ACR22 session 12S127 https://t.co/x3bkUP590A
Janet Pope Janetbirdope ( View Tweet)
So does PsA affect your capacity to work?
DISCOVER-2 analysis:
It’s presenteeism, not absenteeism which is the issue
PsA pts drag themselves into work, but treating them helps them actually do their job. We need to fund more rheumatologists!
ABST0509 @RADoctor #ACR22 @RheumNow https://t.co/Jnac6mV9O5
David Liew drdavidliew ( View Tweet)
#RheumPearl: Dr. J Stone shares useful #ophthalmology terms that #rheums should know. Note that IOI may not be idiopathic (do the workup- it might be #sarcoid myositis). Does @DGlaucomflecken have anything to add? #ACR22 @rheumnow https://t.co/bxWm7MlePj
TheDaoIndex KDAO2011 ( View Tweet)
Michailidou et al. Predictive models VTE in GCA. Predictors Age, inpatient status at the time of diagnosis of GCA, numberof admissions before diagnosis of GCA, Charlson comorbidity index @rheumnow #ACR22 Abstr#0458 https://t.co/TVZ53sERrS https://t.co/JzUuEZThY0
Richard Conway RichardPAConway ( View Tweet)
BIOBADASAR study of cancer risk in RA patients with prev cancer treated with b/tsDMARD. No increased risk, but yet again abatacept numbers are making me slightly nervous! @rheumnow #ACR22 Abstr#0267 https://t.co/H8gYm9STT3 https://t.co/sEIS6Ljwao
Richard Conway RichardPAConway ( View Tweet)
Rheumatology Secrets & Pearl Lecture
with Dr. John Stone:
- Patient presenting with fever, headache, neck pain, and CPPD of multiple joints.
- Consider Crowned Dens Syndrome. CT Neck showing calcification around Odontoid Process
@RheumNow #ACR22 https://t.co/Md1bqzPyr5
Akhil Sood MD AkhilSoodMD ( View Tweet)
Henningson et al. IV methylpred in GCA. No better visual acuity, higher cumulative GC at 3 months, higher diabetes. Interesting! I find it so hard not to give, in case the contralateral eye gets it, but no evidence for this @rheumnow #ACR22 Abstr#0459 https://t.co/yMcw2HGQUx https://t.co/tNKUgYNTdG
Richard Conway RichardPAConway ( View Tweet)
Morning stiffness has the highest correlate to disease activity in pregnant AS patients, as demonstrated in Abs 0374. I will indeed be focusing on this much more for my patients. #ACR22 #ACRbest @RheumNow https://t.co/9bmlQtGsLH https://t.co/qrxebQ6Ow1
Dr. Rachel Tate uptoTate ( View Tweet)
RheumNow’s expanded coverage of the #ACR22 Annual meeting is sponsored in part by Novartis. All content chosen by RheumNow & its Faculty
Dr. John Cush RheumNow ( View Tweet)
Kunishita et al Abatacept in those with RA and prev cancer (or not). Equally effective. No significant difference in 5-year malignancy but those curves look like they are diverging to me! @rheumnow #ACR22 Abstr#0255 https://t.co/1E2SXMGbqD https://t.co/gTvOOnuzo0
Richard Conway RichardPAConway ( View Tweet)
What do you do if a person with #rheumatoidarthritis was great on 1st JAKi. It was 1st line advanced Rx @RheumNow #ACR22
Janet Pope Janetbirdope ( View Tweet)
They're #dopplegangers! #IgG4RD and #GPA both can have similar clinical manifestations, storiform fibrosis and elevated IgG4 levels. Distinguishing factors can be: necrosis, granulomatous inflammation, neutrophilic inflammation, and presence of ANCA #ACR22 @rheumnow https://t.co/6bHibsvcV8
TheDaoIndex KDAO2011 ( View Tweet)
DISCOVER-2:
Guselkumab in bionaïve PsA
Work productivity data at 2 yrs
64% employed at BL; 50% work impairment at BL
84% employed at BL continued to work
Amongst unemployed at BL proportion of pts working rose by >=20%
https://t.co/zqmfFvPPMi
Abst #0509 #ACR22 @Rheumnow https://t.co/J9Fhj1qHfV
Aurelie Najm AurelieRheumo ( View Tweet)
Migratory oligoarticular arthritis of AAV favors the lower extremities and may herald a flare. – Dr. J Stone #ACR22 @rheumnow https://t.co/VdBaeNyCR3
TheDaoIndex KDAO2011 ( View Tweet)
Yamaguchi et al. Effect of concurrent RO62 abs in Jo1+ antisynthetase syndrome. Present in 16%. Associated more muscle involvement 85% vs 59% (p=0.011). Maybe more Raynauds 56% vs 38% (p=0.09)
@rheumnow
#ACR22 Abstr#0162 https://t.co/6XH6qNKkn7 https://t.co/1JQCtCWrw0
Richard Conway RichardPAConway ( View Tweet)