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CAR-T cells in #sle - talk of the town this year!
reset the immune system?
deep depletion CD19+ B cell and tissue plasmablasts.
5 pts with SLE - drug free remission at 8 months.
Costs and risks still limiting use widely.
year in review #ACR22 @rheumnow https://t.co/ophgPjCDuF
Bella Mehta bella_mehta ( View Tweet)
Data from - CARRA registry sJIA-Lung Disease cohort -
Affects 1 in 20 pts - Interstitial lung disease (ILD) and pulmonary alveolar proteinosis (PAP).
13 pts - common features - tachypnea, clubbing, cough, finger and toe erythema
#MAS in 56% pts.
@RheumNow #ACR22 abst#0864 https://t.co/Q8fEzOkjJ7
Bella Mehta bella_mehta ( View Tweet)
Sode et al Mortality in GCA. Dominated by CV disease and higher than controls. Less cancer than controls @rheumnow #ACR22 Abstr#0467 https://t.co/TsfTWFRxJ2 https://t.co/lCZgVTpKUY
Richard Conway RichardPAConway ( View Tweet)
Kaeley et al. Evaluation of success of RA treatment. 69% LDA, 17% MDA, 14% HDA. Common barriers - medication access 27%, non-adherence 20%, co-morbidities 20%, non-inflammatory pain 13% @rheumnow #ACR22 Abstr#0077 https://t.co/c7euuzSx1m https://t.co/9ZN14ph5kI
Richard Conway RichardPAConway ( View Tweet)
@AlexisOgdie at #ACR22:
Ab0189 Ignite 🔥
PEST screening in patients with PsO w/o diagnosis of PsA - captures pts at highest risk. Decrease QoL, higher co-morbdities
High sensitivity test for screening
But is it capturing other co-morbidities (obesity, depression?)
@RheumNow
Eric Dein ericdeinmd ( View Tweet)
What factors influence visit preferences in pts w/ rheumatic dse? @rheumarhyme @doktora_ging
Interesting findings by Dr MDanila et al:
👉In-person visits due to org/clinic level influences
👉#telemedicine visits due to individual level influences
#ACR22 @RheumNow ABST0193 https://t.co/HcCUeahH8L
sheila RHEUMarampa ( View Tweet)
Pregnancy associated back pain and fatigue during 3rd trimester of pregnancy may affect accuracy of BASDAI score in women with AS. Morning stiffness has the highest classification value #ABS0374 #ACR22 @RheumNow https://t.co/DozZ6bxSU3
Olga Petryna DrPetryna ( View Tweet)
Rhee et al. MRI can, and frequently does, visualise enhancement in multiple cranial arteries @rheumnow #ACR22 Abstr#0473 https://t.co/iTtvl2DSoi https://t.co/tUV2zYIO8y
Richard Conway RichardPAConway ( View Tweet)
Brunetta et al. Is serum ANCA assoc malignancy? No @rheumnow #ACR22 Abstr#0450 https://t.co/dCJUZVvAqy https://t.co/K27Rk5tLSU
Richard Conway RichardPAConway ( View Tweet)
Levinson et al. Comparative risks of Alzheimers in inflammatory diseases. SLE (OR 1.31) and IBD (OR 1.17) higher risk than controls, RA, or PsO/PsA @rheumnow #ACR22 Abstr#0062 https://t.co/PbRa033e0L https://t.co/ENycKG4cyQ
Richard Conway RichardPAConway ( View Tweet)
Mechanistic target of rapamycin (mTOR) inhibitors may be successful tx of sarcoidosis. Abs 0136 is an interesting study yielding more questions than answers. #ACR22 @RheumNow https://t.co/0Q260CGw3r https://t.co/LepPOrq7Gv
Dr. Rachel Tate uptoTate ( View Tweet)
Benavides et al. "Optimisation" of tocilizumab in GCA. Dose decreased or interval increased. 231 patients. Sustained remission 78.2% optimised group (vs 66.7%). @rheumnow #ACR22 Abstr#0474 https://t.co/jPRy4RjfJA https://t.co/b1CP8pFwhJ
Richard Conway RichardPAConway ( View Tweet)
Adding MTX to Pegloticase for 52 wks in gout
◦ Improved response rate by 30%
◦ Reduced discontinuation rate by 40%
◦ Greater resolution of tophi by 20%
◦ Similar safety profile in MTX vs non-MTX groups
Botson J MIRROR RCT https://t.co/ifXLdvOv0K #ACR22 #ACRBest @RheumNow
Dr. Antoni Chan synovialjoints ( View Tweet)
Fussner et al. Alpha1-antitrypsin alleles in AAV. Deficiency alleles in 16%. More likely MPA, MPO+. Less likely MSK symptoms, granulomatous disease @rheumnow #ACR22 Abstr#0439 https://t.co/Zi7H5UaolS https://t.co/Z04TvugnnE
Richard Conway RichardPAConway ( View Tweet)
#abs0380 #acr22 @rheumnow OM1 PsA cohort retro: PsA pts w/comorbidities &prior biologic use (both TNFi&SEC) respond well to IXE after 12 mo even w/monotherapy:IXE mono (82% pts) change in CDAI from BL to 6 mo -3.6 points& 12 mo -4.9 pts (statistically significant for both) https://t.co/5dRk86A9Xr
Olga Petryna DrPetryna ( View Tweet)
de Boysson et al. Incidence GCA across France. Variation in SIR from 7 to 12.Increasing east-west gradient @rheumnow #ACR22 Abstr#0475 https://t.co/XDSSrJcMu5 https://t.co/nlJjcPB3zo
Richard Conway RichardPAConway ( View Tweet)
Abs 0373 details SpA-uveitis more severe in pts w/ smoking hx, axial & peripheral involvement, BASDAI >4, +HLA-B27, female sex, ^ CRP, hx of B ocular involvement. #ACR22 @RheumNow https://t.co/Fg0v6NVQcI
Dr. Rachel Tate uptoTate ( View Tweet)
Mudano et al. explore reasons for COVID-19 vaccine hesitancy. For primary vaccination safety concerns most common reason at 52%. For booster, lack of recommendation from physician biggest factor at 39%. @rheumnow #ACR22 Abstr#0083 https://t.co/ISdTmOjIWs https://t.co/Qr47Or2a6v
Richard Conway RichardPAConway ( View Tweet)
Sun et al. 44% improved adherence in people with SLE following a 3.8 minute intervention involving improved communication @rheumnow #ACR22 Abstr#0063 https://t.co/sFU1FzLUfB https://t.co/9AIOijpI0j
Richard Conway RichardPAConway ( View Tweet)
#abst0199 #acr22 @rheumnow phase II study: Izokibep -highly potent IL-17A inhibitor w/small molecular size designed to overcome limitations of monoclonal Abs: dose-dependent improvement in SF36 & PsAID subdomains, notable improvements in sleep, pain& function. Best in enthesitis https://t.co/VSvhr87PK0
Olga Petryna DrPetryna ( View Tweet)