Tanezumab: A Win as Last-Ditch Osteoarthritis Tx

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A phase III study of the nerve growth factor and monoclonal antibody tanezumab showed positive results in a refractory patient population with knee or hip osteoarthritis (OA) -- good enough that this agent may finally be approved after a long and rocky development road.

NICE Guidelines on Managing Rheumatologic Conditions During COVID-19 Pandemic

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On April 3rd, the National Institute for Health and Care Excellence (NICE) in the UK, published a rapid guideline for managing children and adults with rheumatological autoimmune, inflammatory and metabolic bone disorders during the COVID-19 pandemic, while protecting staff from infection.

The Immunologic Basis of Wellness in the COVID-19 Era

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We indeed are living in interesting times and we all are seeking not to contract COVID-19 - this is logical. While our goal is to avoid infection, I think we all must agree that our aspirations must encompass more than disease avoidance. What we should be seeking now, as well, is more than absence of disease but rather a state of optimal wellness.

Global Rheumatology Alliance Registry Will Study COVID-19

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In the midst of a global pandemic of the 2019 Novel coronavirus acute respiratory disease (COVID-19), a small handful of Rheumatologists gathered on social media to collectively grapple with the impact of this virus on vulnerable populations with rheumatic disease.

COVID-19 Rheumatology News

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With the COVID-19 pandemic dynamically changing, we have provided several news items germane to the Rheumatologist.

The COVID-19 Global Rheumatology Registry

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As the highly virulent SARS-CoV-2 spreads over the world, uncertainty and fear for our patients with rheumatic diseases mount.  

Diabetes in OA: Pain Is Worse

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Among patients with knee osteoarthritis (OA), pain was greater for those with coexisting diabetes mellitus (DM), and this association was independent of obesity and radiographic severity, European researchers found. 

RheumNow Podcast - Despite Corona (3.6.20)

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Dr. Jack Cush reviews the news and journal articles from the past week on RheumNow.com.

Need for Disruptive Innovation in Rheumatology

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A full-read, novel Viewpoint article published in the Annals of Rheumatic Disease (Huizinga TWJ, et al) spotlights a recent international meeting of big thinkers, scientific collaborators and industry dedicated to innovation in rheumatology.

Drug Interactions with Cannabinoids

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Cannbinoids are widely available and used for a variety of indications, but little is known about their safety and their potential for drug interactions. The Canadian Medical Journal has published a review of drug interactions with cannabinoids, many of which are mediated by cytochrome-P450 metabolism.

RheumNow Podcast- Methotrexate Mechanisms (2.28.20)

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Dr Jack Cush Reviews the news and journal articles from the past week on RheumNow.com

Fatigue Looms Large in Lupus

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Fatigue is an important component of the disease experience in systemic lupus erythematosus (SLE), and can have a profound impact on patients' perception of well-being, Italian researchers reported.

RheumNow Podcast - RWCS Quick Hits (2.14.20)

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Dr. Jack Cush reviews the highlights from the 2020 RWCS meeting in Maui, Hawaii.

Half of Opioids Rx Come from 1% of MDs

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The BMJ reports that while most US providers are cautious in their prescribing, half of opioid prescriptions are written by 1% of providers.

Between 2003 and 2017, there was an annual average of 669495 providers prescribing 8.9 million opioid prescriptions.

NSAIDs May Impair Healing if Taken Nightly

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A new study in Scientific Reports suggest that circadian rhythms play an important role in wound healing, and that nonsteroidal anti-inflammatory drugs (NSAIDs) may be disruptive if taken at night given primary healing that occurs in a body at night. 

Poor Sleep Increases Risk of Cognitive Decline

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The Journal of Neurology, Neurosurgery & Psychiatry reports there is moderate evidence that six sleep disorders (insomnia, fragmentation, daytime dysfunction, prolonged latency, rapid eye movement sleep behaviour disorder and excessive time in bed) significantly increases the ri

RheumNow Podcast- Knee Pain Knockout (1.10.20)

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Dr. Jack Cush reviews the news and journal reports from this past week on RheumNow.com. The podcast covers: best therapies for dactylitis and enthesitis; we have a new knockout for knee pain in OA; and are you on the naughty or nice list when it comes to the new ACR-AF guidelines for arthritis? This and more. Tune in.

Best Practice Recommendations in Musculoskeletal Care

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A group of Western Australian clinicians have set out to assess current practices and proved guidance recommendations for high-quality care for the most common musculoskeletal (MSK) pain scenarios encountered by clinicians in emergency and primary care.

Domestic Abuse Linked to Fibromyalgia and Chronic Fatigue

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Domestic violence was found to predispose to a higher risk of fibromyalgia and those developing chronic fatigue syndrome.