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All in the Family (8.23.2024)
Dr. Jack Cush picks highlight reports from the past week on RheumNow.com, with reports on the challenge of lupus nephritis, perplexing skin issues, you don't know JAK (about Tyk) and the value of a good family history.
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Predictors of Pregnancy Outcomes in Systemic Lupus Erythematosus
A systematic review of preconception predictors of pregnancy outcomes in women with systemic lupus erythematosus (SLE) highlighted lupus nephritis, chronic hypertension, SLE disease activity and secondary antiphospholipid syndrome as predictors of adverse pregnancy outcomes. Pregnancies in women with SLE have historically been described as challenging, both because of the risk of disease flare and of adverse pregnancy outcomes.
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Lead with Lupus (8.2.2024)
Dr. Jack Cush reviews the news and journal reports from this past week on RheumNow.com - leading with lupus because everyone wants to know about lupus!
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Location, Location, Location (7.26.2024)
Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow.com. Location matters; Geo-rheumatology?
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Sequential Belimumab and RTX in SLE
Could disease control in active SLE patients be improved by the sequential use of subcutaneous BEL and intravenous RTX? A double blind trial has shown that sequential BEL and RTX was not superior to BEL alone in SLE.
https://t.co/CO0ltRX9Eo https://t.co/zey2UE4BRu
Dr. John Cush RheumNow ( View Tweet)
Predictors of Pregnancy Outcomes in SLE
A review of preconception predictors of pregnancy outcomes in women with SLE highlighted lupus nephritis,chronic hypertension, SLE disease activity and secondary antiphospholipid syndrome as predictors of APO.
https://t.co/vA445kSe5t https://t.co/wGhLjCmJ3v
Dr. John Cush RheumNow ( View Tweet)
100 top-cited studies in #SLE. 60% from USA; half focused on underlying mechanisms
#1 1982 1982 Revised Criteria for.. Classification ..SLE
#2 Updated ACR Criteria...
#3 Derivation of SLEDAI https://t.co/g3fcUqtsct https://t.co/HlGfGC4aci
Dr. John Cush RheumNow ( View Tweet)
🔥 One of the most important articles of the year showing medical evidence for disease-modifying (organ damage prevention) therapies in #SLE #lupus:
CLICK 👉 https://t.co/Qmia9Gc8mu
Kudos to the authors for such an important piece of work. Open up the table in the article and… https://t.co/z9osFAavud https://t.co/lWjkwMEHrq
Links:
Donald Thomas, MD lupuscyclopedia ( View Tweet)
Metanalysis of 50 RCTs (3,231 pts w/ lupus nephritis (LN) related starting pred dose to rates of complete response (CR), serious infections, & death. PO pred 25 mg/D assoc w/ 20%, 3.2% & 0.2%, respectively. Pred 60 mg/day incr rates to 35%, 12% & 2.7% https://t.co/6FH9BWsmaz https://t.co/0cQPAIuvRw
Dr. John Cush RheumNow ( View Tweet)
Pregnancy, menopause, contraceptives, hormone replacement, aromatase inhibitors may affect lupus outcomes. Review says hormone therapies are contraindicated w/ antiphospholipid syndr, APL Ab positivity, and uncontrolled SLE or flares https://t.co/bZQr8b871n https://t.co/OmXY04GR4p
Dr. John Cush RheumNow ( View Tweet)
Lead with Lupus (8.2.2024)
Dr. Jack Cush reviews the news and journal reports from this past week on https://t.co/V10S4oVFsv - leading with lupus because everyone wants to know about lupus!
https://t.co/kzoijNGyfd https://t.co/S2llbb0pMO
Dr. John Cush RheumNow ( View Tweet)
NEJM Case: A 29-year-old woman with SLE presented to the dermatology clinic with 2-weeks of itchy, painful rash on her nose and hands that came on with cold weather. What do you think? https://t.co/jm0Zzu1gfj https://t.co/sAgZipPmaC
Dr. John Cush RheumNow ( View Tweet)
Medical literature review of suggests low vitamin D status is common in Rheumatic pts. & low vit D levels linked to loss of muscle strength, MSK pain, sarcopenia & falls (esp in IIM, PMR, SLE, RA, SSc) (BUT DOES REPLACING VITAMIN D FIX THESE PROBLEMS???) https://t.co/30IiKj7l4d https://t.co/ydU6FQMTi5
Dr. John Cush RheumNow ( View Tweet)
US Childrens Hosp Admission database finds 8588 kids w/ SLE & ≥ 1 hospitalization; 13% for infections, w/ Bacterial pneumonia most common. cSLE In-hospital mortality in 0.4%, but 2% for infection. Highest mortality w/ PJP (21%), fungal infx (21%) https://t.co/fmyRXagCcD https://t.co/yXDMFYhhdP
Dr. John Cush RheumNow ( View Tweet)
TRUST: 10 Yr Japanese study of tacrolimus in 1355 SLE nephritis pts; half on TAC x 10yrs. TAC use assoc w/ signif reduction corticosteroid use (~16 mg/d @4wks to 7.2 mg/d @ 1Yr(P < 0.001). 9.7% w/ serious AEs. https://t.co/PsfCVZF4tk https://t.co/l3HkTRc4oC
Dr. John Cush RheumNow ( View Tweet)
Lg prospective (2013-2020) multinational, cohort of 3449 #SLE pts (F/U 2.8 yrs)- LLDAS (lupus low Dz activity achieved >= once in 73%. Sustained LLDAS >3mos assoc w/ signif less damage (HR 0·60), remission: (0·66) & flare (0·56). https://t.co/AFyOBWcIZf https://t.co/bHjmOuH7wN
Dr. John Cush RheumNow ( View Tweet)
Systemic Lupus Erythematosus and Lung Involvement: A Comprehensive Review
⏩8 types of pleuropulmonary involvement
⏩Diagnosis: CT ,PFT, bronchoalveolar lavage, biopsy, PET.
⏩Exclude infections
⏩High mortality: DAH
https://t.co/jRuW0sFbmw https://t.co/BruY1jwMFl
Links:
Autoinmunes Medicina Interna Parc Taulí autoinMI_tauli ( View Tweet)
DBRPCT of Krill oil (4 g/d;KOC) vs PBO in 78 #SLE pts for 24 wks. KOC Rx pts had signif increase in Omega-3 Index 4.3% to 7.17% (4wks) to 8.05% (24wks) w/ no change SLEDAI-2K. But 9pts w/ hi activity (SLEDAI≥9) showed signif Dz activity improvements https://t.co/ODLqqZzGQx https://t.co/tehHk4MhbZ
Dr. John Cush RheumNow ( View Tweet)
Cross-sectional study of 154 adult DLE pts in the Philadelphia area assessed DLE Dz severity (by CLASI) & geoghraphic distribution to ID area deprivation (ADI). ADI > 5 (geospatial disadvantaged) was assoc w/ signif (4X) higher risk of mod-Severe Damage https://t.co/dgeGwzNTKm https://t.co/B3hmUE1G9U
Dr. John Cush RheumNow ( View Tweet)
UK study of pneumococcal vaccination in UK, shows IMID pts had suboptimal vax against pneumococcus. In 32 277 pts (RA 14151, IBD 13631, SpA 3804, SLE 691) saw 57% vaccinated; lower if <45 yrs (32%), IBD (42%). Vax not associated w/ IMID flare https://t.co/y5JHYaEpA9 https://t.co/zUXfDoqyal
Dr. John Cush RheumNow ( View Tweet)
