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SLE Preview: abolishing refractory with CAR-T and better B-cell therapies
Inhibition of B cell activating factor (BAFF) and B cell depletion are the two most evaluated strategies over the last 15 years in the field of SLE therapeutics, with licensing of belimumab and off-label use of rituximab.
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OP0048 Impressive CLASI (lupus skin index score) with #deucravacitinib - data presented by Dr C Arriens #EULAR24 @RheumNow #WiR https://t.co/EuQdwuolN6
TheDaoIndex KDAO2011 ( View Tweet)
Novel B cell depleters! Bispecific T cell engagers (BiTEs) being studied for #SLE & #RA as a way to get CAR-T cell like responses but more accessible w/less risk for CK release syndrome. #EULAR24
T cell-engaging therapies — BiTEs and beyond | Nature Reviews Clinical Oncology
TheDaoIndex KDAO2011 ( View Tweet)
#EULAR2024 Please find my article on a preview of interesting abstract to look out for for #lupus #SLE therapies at this year’s congress @RheumNow
https://t.co/TEtrDWq3BF https://t.co/1zIIxsaeL2
Links:
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
Genetic Risk scoring can predict adverse outcomes in #SLE #EULAR2024 @RheumNow https://t.co/g9kGdRkCOh
Bella Mehta bella_mehta ( View Tweet)
Systematic Review of #SLE pregnancies in Latin America – 44articles, 4K patients, Hispanic/ Latino with increased preeclampsia when they have LN #EULAR2024 Abst#0986 @RheumNow
Bella Mehta bella_mehta ( View Tweet)
Digital technologies and health in #SLE can be integrated at several stages, but still a needs a bridge between #AI and #humanintellegence #EULAR2024 @Lupusreference @RheumNow https://t.co/1aN8QPgVWn
Links:
Bella Mehta bella_mehta ( View Tweet)
Treat to target in #lupus - difficult for many reasons.
Also may be too much of a restrictive strategy.
@Lupusreference talks about DORIS definition of remission- however mentions may be difficult to do in daily practice #EULAR2024 @rheumnow https://t.co/XqiubfOz2n
Links:
Bella Mehta bella_mehta ( View Tweet)
Many drugs in the horizon for #lupus @Lupusreference lecture #EULAR2024
Loved the timeline of all major drug -phase 2 and 3 drugs.
Need for new strategies in Lupus – outcomes and survival is plateauing!
@RheumNow https://t.co/Ue239woQJr
Links:
Bella Mehta bella_mehta ( View Tweet)
Clinical pearl in #SLE pregnancies #EULAR2024 Whats new in lupus session.
Measure Hydroxychloroquine levels! @RheumNow https://t.co/OnktkMSPR5
Bella Mehta bella_mehta ( View Tweet)
Lupus GPT - a chatbot which is much more relevant to Lupus - for patients and physician question etc. #EULAR2024 - Will be functional soon.
Looking forward to playing with this. #LLMs #ChatGPT
More to come. @RheumNow https://t.co/mGXG6A85Hx
Bella Mehta bella_mehta ( View Tweet)
Biomarkers in Lupus - Urine biomarkers @andreafava in #EULAR2024
We need these biomarkers to come in mainstream clinical practice if they work better than proteinuria. @RheumNow https://t.co/i7aeBx6qRR
Bella Mehta bella_mehta ( View Tweet)
@Lupusreference noted data suggests pulse IV methylprednisolone yields better outcomes for LN than adjustments of chronic oral steroids. #EULAR24 @RheumNow https://t.co/n93x036uIn
TheDaoIndex KDAO2011 ( View Tweet)
Precision medicine in Lupus is far from reality today. @Lupusreference @RheumNow #EULAR2024
Bella Mehta bella_mehta ( View Tweet)
Whats new in Lupus #EULAR2024 @Lupusreference lecture - many pearls.
Corticosteroids IV may be the way to go - referencing @AliDuarteMD team (better outcomes compared to oral steroids)
@RheumNow https://t.co/Fz1dZUVomF
Links:
Bella Mehta bella_mehta ( View Tweet)
Should we treat to target (T2T) for #SLE or just do SOC and gestalt (as most do in clinical practice)? @Lupusreference #EULAR24 @RheumNow
TheDaoIndex KDAO2011 ( View Tweet)
Dr. G Schett reported using CAR-T cell Rx in patients w/ 1. pedi-SLE 2. CNS lupus 3. refractory cases with success. Post- Rx vaccine response is fine, infection risk is less since pts no longer need steroids. He is still following the pts for relapse and AEs @RheumNow #EULAR24
TheDaoIndex KDAO2011 ( View Tweet)
Pt with LN, endocarditis, pericarditis, arthritis, rash failed CTX, MMF, BEL, and SOC. She is 1000 days post CAR-T cell. Off immunomodulating drugs. #SLE in remission clinically and serologically. - Dr G Schett #EULAR24 @RheumNow https://t.co/3vdMtO6VWI
TheDaoIndex KDAO2011 ( View Tweet)
🌎 Global disparities in steroid prescribing in #SLE
💊 HCQ assoc with decreased steroid use
📈 Other contributing factors may be prevalence, severity & phenotype of disease, plus access to DMARDs & biologics
📍SLE poster tour 15:30 TODAY
#EULAR2024
Abs #POS0013
@RheumNow https://t.co/7pL8kpeqOs
Mrinalini Dey DrMiniDey ( View Tweet)
#AB1039 Spanish study 76 LN patients postrenal transplant: 77% females, HTN (68%), LN class IV (42%), mean age 55. Graft loss in 35.5% b/c of acute rjx (22%), chronic rjx (22%), acute w/chronic rjx (22%), graft thrombosis 14.8%, recur LN (11%) #EULAR24 @rheumnow https://t.co/d82i0Z7LUB
TheDaoIndex KDAO2011 ( View Tweet)
