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Polymyalgia rheumatica immunological puzzle further illustrated
Infiltrating macrophages expressing IL-6 and GM-CSF may drive the subacromial bursitis often seen in polymyalgia rheumatica, according to new research (abstract OP0015) prese
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SLE trials update
Translating targeted therapy from bench to bedside has been more problematic in SLE than other autoimmune diseases, with many theoretically well-founded agents appearing to have failed in clinical trials as a result of inefficacy, problem with trial design and/or safety issues.
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Treat-to-target in RA is held with an almost religious fervour in rheumatology, but it's really hard to follow religiously. What happens if you're only T2T observant on the high holidays?
Answer: the world's not too bad!
(2y is bit short I realise)
POS0111 #EULAR2022 @RheumNow https://t.co/Boh74JmsP3
David Liew drdavidliew ( View Tweet)
Watch: Treatment of Pre-RA: Is Early Already Too Late?
Dr. Aurelie Najm reviews abstract OP0070 presented at the #EULAR2022 meeting. #MedEd
https://t.co/ep4lgtZYcT https://t.co/LTx1RMGdkv
Links:
Dr. John Cush RheumNow ( View Tweet)
#EULAR2022 OP0067:
Depression is a major risk factor (6X!) for mortality in RA. Study may show some bias in the methods, but critical findings for all rheumatologists to consider
@RheumNow
https://t.co/leeY9zAx4T
Eric Dein ericdeinmd ( View Tweet)
Updates in Psoriatic Arthritis at EULAR 2022. Here are the topics I will be highlighting at the conference #psoriaticarthritis #EULAR2022 @RheumNow https://t.co/8Dd29GdUuz
Dr. Antoni Chan synovialjoints ( View Tweet)
“Evidence does not support a risk of flares in association with any vaccination.” – Dr. Kimme Hyrich https://t.co/z179YYn9mc
TheDaoIndex KDAO2011 ( View Tweet)
In a rush for a quick update on selected trial results in #lupus presented at #EULAR2022? Please find my article https://t.co/0XTkPRr6kQ @RheumNow
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
To contrast or not to contrast (in RA hand MRI?) POS0718 from #EULAR2022 showed good correlation between contrast/non-contrast imaging in synovitis, less so in tenosynovitis however. https://t.co/xL4XcRlIog
@RheumNow https://t.co/0cTep6MHLu
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Dr. Rachel Tate uptoTate ( View Tweet)
WATCH: Can Dermatologists Help Detect Psoriatic Arthritis?
Dr. Robert Chao reviews abstract OP0029 presented at #EULAR2022 in June.
https://t.co/bAuCsVLJV2 https://t.co/BjUckSXIJ3
Links:
Dr. John Cush RheumNow ( View Tweet)
Top Influencers of #EULAR2022: @eular_org @RichardPAConway @RheumNow @EMEUNET @rheum_cat @Yuz6Yusof More 📊 https://t.co/fUfohEZAoX
Symplur Hashtags healthhashtags ( View Tweet)
Beyond capillaroscopy, US vascular imaging dorsal/ventral fingers can improve detection of vasculopathy of SSc in patients with Rayanaud's (RP) by Nam et al. The % vascular areas in patient's with RP was significantly lower in SSc vs normal volunteers #EULAR2022 @RheumNow POS0127
Dr. Antoni Chan synovialjoints ( View Tweet)
Methotrexate plus leflunomide combination therapy for PsA treatment resulted in greater improvement in disease activity when compared to MTX monotherapy. As expected, MTX+LEF less well tolerated.
@RheumNow #EULAR2022 ABST#0078 https://t.co/Bo64QX3Bf9
Robert B Chao, MD doctorRBC ( View Tweet)
Women with spondyloarthritis at increased risk of gestational diabetes, elective and emergency C-sections, and spontaneous pre-term birth. Infants were not more likely to be born SGA.
@RheumNow #EULAR2022 ABST#OP0126 https://t.co/BTXQqruvPs
Robert B Chao, MD doctorRBC ( View Tweet)
Study of 2.9k offspring exposed to adalimumab, infliximab, golimumab during pregnancy, as compared to etanercept and certolizumab showed an adjusted hazard ratio for serious infections of 1.20 (CI 0.54, 2.64).
@RheumNow #EULAR2022 ABST#OP0130
Robert B Chao, MD doctorRBC ( View Tweet)
#OP0146 #EULAR2022 Is Anti-Ro(52) ab+ on isolation clinically significant? A study of 300 #Sjogren patients showed milder tissue inflammation but a higher risk for fibrosis (lungs) in this group. Interesting to see transcriptomic analysis to identify appropriate target @RheumNow https://t.co/vdxedCI2pk
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
Are TYK2 inhibitors ‘ticked’ to be part of the JAK family?
Are Tyk2 inhibitors JAK inhibitors?
Yes, no, maybe
Check out all of Dr. Janet Pope’s TYK2 Q&A.
https://t.co/IqeGqt6M4t https://t.co/kjWLVKVFP7
Links:
Dr. John Cush RheumNow ( View Tweet)
Differentiating AS from OCI using CT scanning by Terrier et al showed that Subchondral Bone Attenuation Coefficient (SBAC) was higher in OCI than AS with a threshold of >7500 Hounslow Units discriminating the two conditions #EULAR2022 @RheumNow POS0126 https://t.co/8MdSe3Dqp7
Dr. Antoni Chan synovialjoints ( View Tweet)
Measuring liver stiffness (LS) by transient elastography can detect and follow up hepatic involvement in AL amyloidosis as radiolabelled SAP scan not widely available by Brunger et al . Higher LS in with liver involvement vs heart/no involvement #EULAR2022 @RheumNow POS0124
Dr. Antoni Chan synovialjoints ( View Tweet)
GM-CSF increased in patients with active ankylosing spondylitis, correlates with disease activity, not duration. TNFi does not affect GM-CSF levels. Could explain efficacy of JAKinibs and response for residual inflammation during TNF blockade.
@RheumNow #EULAR2022 ABST#OP0107
Robert B Chao, MD doctorRBC ( View Tweet)