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Spanish safety registry BIOBADASER 3.0:
*9000+ pts with IMID treated w/ bio or tsDMARDS
*352 pts w/ prior malignancy
*32 incident malignancies
-> 27 events/1000PY
NO diff between ttmts in incidence or mortality but low number pts in non TNFi groups
@RheumNow #EULAR2022
OP0138 https://t.co/8IyC6NdGCF
Aurelie Najm AurelieRheumo ( View Tweet)
The PROOF study showed the predictors of radiographic progression included male gender HR 3.16, good response to NSAIDs HR 4.66, fulfillment of the imaging arm HR 6.64 and HLA-B27+ HR 3.99 by Poddubnyy et al #EULAR2022 @RheumNow OP0149
Dr. Antoni Chan synovialjoints ( View Tweet)
#EULAR2022 OP0139
Has your pt asked about sexual fxn?
Sexual dysfxn (SD) (CSFQ-14 questionnaire) and joint disease
188 AI pts, 89 controls
Nearly 50% of RA pts had SD, 30% in PsA. Only 6% in control group!
High depression in group, but not found as rf
@RheumNow https://t.co/WvBw3cnFKC
Eric Dein ericdeinmd ( View Tweet)
#ClinicalPearl #SLE Rx tomorrow? Combine #Ritux+#Belimumab variable response, CART Rx for severe refractory #lupus, antiCD38i, drugs i. RCTs=hope for pts. #EULAR2022 T Dorner @RheumNow @eular_org https://t.co/2BReU5bhG0
Janet Pope Janetbirdope ( View Tweet)
Tang et al. Prediction of 6-month mortality in MDA5-DM. Fever, ferritin≥1250, and positive carcinoembryonic antigen (CEA) predictive in Chinese population @RheumNow #EULAR2022 OP0163 https://t.co/byDiHZhcGK https://t.co/95Wx4quQMP
Links:
Richard Conway RichardPAConway ( View Tweet)
No need to switch TNFi during pregnancy. Study compared high placental vs. low placental transfer TNFi- no sig difference for SIE in childhood. Dr. L Flatman comparing different TNFi in pregnancy: 26,000 offsprings #EULAR2022 @rheumnow OP0130 https://t.co/IF5hepQoHc
TheDaoIndex KDAO2011 ( View Tweet)
#SLE hospitalized pts had worse outcomes than matched controls ? Due to interfonopathy and poor handling of viral infections - worse if #Rituximab or #MMF T Dormer BUT vaccination works if enough B cells responding to #Covid vaccine #EULAR2022 #Lupus scientific session @RheumNow https://t.co/MBb3Dvxmqp
Janet Pope Janetbirdope ( View Tweet)
The GESPIC cohort reports in Axial PsA, 75% had inflammatory back pain, 45% met NY criteria for AS, 55% with active inflammatory change in SI joint and 60% in the spine. This is where the overlap between Axial PsA and Axial SpA happens, Kading et al #EULAR2022 @RheumNow OP0026
Dr. Antoni Chan synovialjoints ( View Tweet)
Pregnancy outcomes in SpA
Increased risk of
❗️gestational diabetes aRR 1.88
❗️Cesarean delivery aRR 1.54 & 1.23
❗️preterm birth aRR 1.52
❗️trend for increased infection
in 1st year of life in newborns aRR 1.23.
#EULAR2022 @RheumNow OP0126 https://t.co/jMryB5UXQr
Aurelie Najm AurelieRheumo ( View Tweet)
Million $$$ questions presented to Prof T Dorner: anifrolumab vs. belimumab for #SLE? He prefers belimumab d/t more data on multiple organ manifestations ^ it might be protective in pts w/ COVID19 infection. If skin dz is predominant, then anifrolumab #EULAR2022
@rheumnow
TheDaoIndex KDAO2011 ( View Tweet)
Patient with 12 weeks inflamm-sounding arthralgias and functional impairment, high titre RF/CCP, osteitis on MRI, no clinical synovitis on exam.
Do you suggest to patient to treat with methotrexate?
#EULAR2022 @RheumNow
David Liew drdavidliew ( View Tweet)
What does avacopan mean for sustained remission in AAV?
New post-hoc from ADVOCATE - keeping in mind the avacopan was instead of steroids. Impressive numbers, so increasingly the questions will be about strategy and cost?
#EULAR2022 @RheumNow https://t.co/B4y8jZiHf5
David Liew drdavidliew ( View Tweet)
🚨 Study on MTX and male fertility
Analysis of semen parameters in
🙋🏼♂️HC
🙋🏼♂️RA, PsA and PsO MTX naive
🙋🏼♂️Post MTX
Reassuring data as NO significant effect of MTX was observed on several semen parameters.
#EULAR2022 @RheumNow
OP0131 https://t.co/Fq32lzAMAx
Aurelie Najm AurelieRheumo ( View Tweet)
#Belimumab safety in pregnancy
EudraVigilance database retrospect study 47 preg: BEL stopped 1st trimester (group A) vs. cont'd (group B)
- no diff in fetal death
- more preterm birth/low birth weight, congenital malform'n in group A (not stat sig) #EULAR2022 @rheumnow POS0705 https://t.co/sLQ3MHNcWa
TheDaoIndex KDAO2011 ( View Tweet)
#COVIDvaccine is effective in active and inactive #SLE disease. Noted reduced response for MMF, MTX, GC>10 mg/day. Threshold of B cells is 9+ cell/uL to have a vaccine response. Prof T Dorner #EULAR2022 @rheumnow https://t.co/qyNUZxMccD
TheDaoIndex KDAO2011 ( View Tweet)
RABBIT registry data on CV events with JAKi. Incidence rate low 0.41/100PY. No increase compared to TNFi RR 0.94 (0.39-2.38). No increase in high-risk group RR 0.90 (0.37-2.17). Reassuring with wide CI's. @RheumNow #EULAR2022 OP0135 https://t.co/vBSsnfeBoR https://t.co/iYDZsNwMye
Links:
Richard Conway RichardPAConway ( View Tweet)
Hamroun S et al for the GR2 Cohort showed that age HR 1.22 and use of NSAIDs HR 3.01 in the pre-conception period was associated with a longer time to conception in women with SpA. Research is needed on continuous NSAID use in the preconception period #EULAR2022 @RheumNow OP0153 https://t.co/hl6jUlK5PN
Dr. Antoni Chan synovialjoints ( View Tweet)
#SLE responses with #anifrolimumab separate vs standard of care+placebo& LLDAS at 12 weeks-predictor was high Type I IFN (younger, ⬆️disease activity) but diff sig for response w #belimumab. At bedside diff to tell pts with various signatures apart. #EULAR2022 @RheumNow Dorner https://t.co/98Sb3MIEps
Janet Pope Janetbirdope ( View Tweet)
#OP0143 #EULAR2022 We need to screen/monitor our patients with #lupus for infection. Amsterdam cohort (>200 pts) reported association of infection and flare. 50% were on steroid. Infection type did not influence flare @RheumNow https://t.co/Pxpx5hXLv9
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
Dementia in RA associated w/
⚡️Large joint swelling HR 2
⚡️Any CVD HR 2.25
⚡️Anxiety HR 1.86
⚡️Depression HR 2.63
at any time during disease course in retrospective cohort 800+ pts
#EULAR2022 @RheumNow OP0134 @MyasoedovaElena https://t.co/MLweRMEZXE
Aurelie Najm AurelieRheumo ( View Tweet)