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Recommendations – Good & Bad (5.27.2022)

d Jack Cush, MD

Dr. Jack Cush reviews the news, regulatory updates and journal reports from the past week on RheumNow.com. This week gout worries, mortality risks, measuring anti-drug antibodies and a better way in lupus?

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Cardiovascular Risk in Calcium Pyrophosphate Deposition Disease

d Jack Cush, MD

The cardiovascular (CV) risks of inflammation and gout are well known, but until recently hasn't been tied to calcium pyrophosphate deposition (CPPD) disease. A recent EHR study shows that acute CPPD crystal arthritis was significantly associated with elevated risks for non-fatal CV events.

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child.guttate.psoriasis

Psoriasis and Nonalcoholic Fatty Liver Disease

d Jack Cush, MD

A large US population based study shows that psoriasis is associated with a higher risk of nonalcoholic fatty liver disease (NAFLD).

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coronavirus,COVID,Mask,red

Increasing Corticosteroid Use in Non-Hospitalized COVID-19

d Jack Cush, MD

JAMA reports that despite NIH recommendations (that corticosteroids only be used in hospitalized COVID-19 patients), nonhospitalized COVID infected patients were oftent prescribed systemic corticosteroids.

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Is Gout Protective Against Dementia?

d MedPage Today

People with gout appeared less likely to develop dementia than age- and sex-matched peers, a database study from Korea found.

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Watch: Treatment Choices in Refractory RA Dr. Cush presents Treatment Choices in Refractory RA, during the RheumNow Live 2022 meeting held in March 2022. #MedEd https://t.co/5wjLyVAS7o https://t.co/dnh8Y5Of4G

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UK experience with 7 cases of monkeypox. Common sxs=fever, rash, HA, lymphadenopathy, LFTs. Complications =pneumonitis, encephalitis, keratitis, bacterial infx. Often skin lesions, abscesses https://t.co/OW3VMtGTGD https://t.co/yTKODreXYg

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To TDM or Not in Rheumatology? Therapeutic Drug Monitoring (TDM), especially for biologic therapies, has become a standard in gastroenterology, but shunned by most rheumatologists. But now, EULAR has a recommendation... https://t.co/u86Vd8bFGr #MedEdTwitter https://t.co/IpKqPoWM9R

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Watch: Adherence to Rheumatoid Therapies Dr. Michaud presents Adherence to Rheumatoid Therapies at the RheumNow Live 2022 meeting held in March. #MedEd https://t.co/sCCnx82ptN https://t.co/GJE0Ktwm7B

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Dr. John Cush RheumNow ( View Tweet)
Visit @RheumNow podcast channel & hear experts from the #SLEEducatorsNetwork review a new framework for defining disease modification in SLE and why there’s a need to consider therapies that modify the immunologic mechanisms of SLE. Sponsored by GSK USMA https://t.co/6HiO63Rthd https://t.co/7rjgj1WqGj

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Watch: Juvenile Spondyloarthritis Dr. Pamela Weiss demystifies juvenial SpA and discusses the unique aspects of the disease. https://t.co/xa2mO0fdzq #MedEd https://t.co/6JVUGRx5Go

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Dr. John Cush RheumNow ( View Tweet)
1049 non-diabetic hospitalized gout pts (2014 -2020); saw an inverse relationship betw CKD & NAFLD, & increaseing negative associations w/ NAFLD severity (mild OR 0.392; Mod: 0.379; Severe 0.148). NAFLD negatively assoc w/ CKD risk in gout https://t.co/5fuIiO1LwM https://t.co/Jp8CjWkn5m

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Dr. John Cush RheumNow ( View Tweet)
NEJM : 40 yoM 2 wk hx scaly foot rash, joint swelling & LBP. 1 wk ago had diarrhea & urethral discharge. Feet show keratoderma blenorrhagicum; PSO on scalp, trunk, hands, nail changes, +swollen joints, CRP 59/L, UA sterile pyuria, B27+ https://t.co/GgKWIbL9Br https://t.co/m0fbg8mJUc

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Dr. John Cush RheumNow ( View Tweet)
🆒 Current indications for #biologics, in inflammatory rheumatic diseases 🔎 such as rheumatoid #arthritis, axSPA, PsA etc... A useful checklist ✅ to keep in the pocket prepared with @DocFelten #Rheumatology #EULAR2022 https://t.co/cfc4VaF6GZ
Laurent ARNAUD Lupusreference ( View Tweet)
A Roadmap for Investigating Preclinical Autoimmunity Using Patient-Oriented and Epidemiologic Study Designs: Example of Rheumatoid Arthritis - a comprehensive overview of studies of preclinical RA and risk of RA https://t.co/DKbDXkvFyQ

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Dr. John Cush RheumNow ( View Tweet)

@ERheumat @mukes_dr @drMsayan @vikasagrIMMUNO @DurgaPrasannaM1 @LatikaGupta_ @Janetbirdope @AshimaMakol @sclerodermaUM @PanktiMehta24 @ACR_Journals Sclerotylosis… Huriez Syndrome? Triad of 1) sclerodactyly 2) palmoplantar keratoderma 3) nail changes. High susceptibility of early onset squamous cell cancer of affected areas

Meral K. El Ramahi, MD MeralElRamahiMD ( View Tweet)

Study of 100 pts w/ gouty arthritis, 51% had hypertension, nearly half insufficiently controlled. Undiagnosed HTN was seen in 18%. Gouty pts w/ HTN frequently (92%) had serum uric acid levels above the target https://t.co/jc0UGyrK2B https://t.co/kDD2KfQd3K

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Can SGLT2 Inhibitors Be Protective in Lupus and Vasculitis? SGLT2 inhibitors are all the buzz in the renal world with reports of a renal protective and mortality lowering effects https://t.co/9mzE06K9uO #MedEd https://t.co/dVgOtCSHFU

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86 #SLE pts w/ pulmonary embolism (age 38 yrs; avg lupus duration 46.5 mos) found 20% died; 1 yr (83.4%) & 3-year survival (79.4%). Mortality Predictors = Thrombocytopenia & lymphocytopenia. HCQ & anticoagulation were protective https://t.co/ot7H6LeLmu https://t.co/WdPgvOF8jJ

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Amitriptyline and FDA Treatments for Fibromyalgia #MedEd https://t.co/9PylojjL4S https://t.co/TxErjtU4eE

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Dr. John Cush RheumNow ( View Tweet)
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