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@Rheumnow #EULAR2022 POS0240
▶️ In 2021, 73.6% of Belgian RA patients staring a JAKi, started a 2nd generation JAKi (UPA, FIL).
Predictors for 1st generation usage (BAR, TOFA): older age, prior DMARD therapies.
What would you start as a first JAKi?
Eric Dein ericdeinmd ( View Tweet)
Household Cleaning is dirty business at least if you have #rheumatoid #arthritis as silica exposure from laundry and cleaning products were associated with RA ILD. #EULAR opening day. #ClinicalPearl #EULAR2022 @RheumNow #OP0006 https://t.co/OJQMy9Fe9m
Janet Pope Janetbirdope ( View Tweet)
Immune Checkpoint Inhibitor Associated Arthritis
Immune checkpoint inhibitors (ICIs) have dramatically improved outcomes in numerous cancers but have been hampered by a growing spectrum of immune-related adverse events (irAEs).
https://t.co/Eno0TcWlNX https://t.co/XjkBlUEFxk
Links:
Dr. John Cush RheumNow ( View Tweet)
ACR21: conditionally recommends against steroids with starting csDMARD
#EULAR2022 recommends with rapid GC dose reduction and discontinuation
Which is better recommendation?
@RheumNow
Eric Dein ericdeinmd ( View Tweet)
#EULAR2022 RA updated reccs w/ minor changes: start MTX+GC, reduce GC rapidly, JAKi are recc only for pts w/o risk factors for CV or malignant dz (not sure I agree with this last one if the JAKi is the best drug for the pt and there are little options avail) @rheumnow https://t.co/CXyyCi6LVI
TheDaoIndex KDAO2011 ( View Tweet)
Overarching principles #EULAR2022 AAV Updated reccs are patient centered:
1. Best care w/shared decision making
2. Access to education on AAV
3. Screen pts for Rx side effects/comorbidities
4. Need a multidisciplinary approach w/vasculitis expertise @rheumnow https://t.co/OgE4l4np12
TheDaoIndex KDAO2011 ( View Tweet)
Musculoskeletal US used by dermatologists helped increasedspecificity of PsA detection, leading to fewer false suspicions of PsA earlier diagnosis of psoriatic arthritis.
@RheumNow #EULAR2022 ABST#OP0029
Robert B Chao, MD doctorRBC ( View Tweet)
After the #EULAR2022 Recommendations session, it begs the question - Do we follow it?
In Germany, the answer is sometimes
Early bDMARD or JAKi is more frequent in recent years. 1/3 of patients did not receive recommended treatment escalation after 1st csDMARD
POS0234 @Rheumnow https://t.co/0DaP5b7Htc
Eric Dein ericdeinmd ( View Tweet)
Real-world data: #SLE Rx & pt willingness to take risk: 342 pts w/SLE surveyed on hypothetical Rx's based on Sx's. Pts value Sx improvement more than risks & rated most➡️least important: joint pain, rash, & fatigue, risk for infx was least impt #EULAR2022 @Rheumnow POS0086-PARE
TheDaoIndex KDAO2011 ( View Tweet)
#EULAR2022 Update ANCA-associated vasculitis
⭐️Last update 2016
▶️Tissue bx important!
▶️RTX for most for remission, maintenance
▶️Lower steroids (50-75 mg, decrease to 5 mg/d by 4-5 mo), can use avacopan to ⬇️
▶️ No routine PLEX
▶️Maintenance is 24-48 mo, tailor to pt
@RheumNow https://t.co/OmCne2lIIb
Eric Dein ericdeinmd ( View Tweet)
#EULAR2022 EGPA recommendations:
Organ or life-threatening? Y = CYC, N = steroid
Relapsing disease? Mepolizumab
@Rheumnow https://t.co/qh564cAhC2
Eric Dein ericdeinmd ( View Tweet)
#EULAR2022 AAV Reccs summarized for induction remission for GPA/MPA @rheumnow https://t.co/Cbp72bCcik
TheDaoIndex KDAO2011 ( View Tweet)
Do you use PJP prophylaxis on patients with ANCA vasculitis on rituximab without high dose steroids?
#EULAR2022 ANCA-associated recommendations
@RheumNow
Eric Dein ericdeinmd ( View Tweet)
#EULAR2022 AAV Reccs for Steroids: start prednisone 50-75 mg/d prednisone and taper to goal 5 mg/day by 4-5 months based on #PEXIVAS @rheumnow https://t.co/6gIfme4HXH
TheDaoIndex KDAO2011 ( View Tweet)
Overarching principles of #EULAR2022 Ax Spa Updated Reccs @Rheumnow https://t.co/g6Hd9NE1vB
TheDaoIndex KDAO2011 ( View Tweet)
#EULAR2022 updated ASAS-EULAR guidelines for the management of axSpA review with Dr. @sofiaramiro82 @RheumNow https://t.co/SHg4y49auA
Dr. Rachel Tate uptoTate ( View Tweet)
#EULAR2022 ASAS Updated Reccs: Treatment Algorithm @rheumnow https://t.co/YEdhrAX0lT
TheDaoIndex KDAO2011 ( View Tweet)
#EULAR2022 ASAS-EULAR guidelines for axSpA with Dr. @sofiaramiro82. Below are the recommendations including b/tsDMARDs. If ASDAS > 2.1 the recommendations call for consideration for TNFi, IL17i, or JAKi. Re-evaluate after at least 12 weeks on tx and for co-morbidities. @RheumNow https://t.co/mryL3YmtzN
Dr. Rachel Tate uptoTate ( View Tweet)
Dr. @sofiaramiro82 important conclusion considerations from the ASAS-EULAR guidelines for axSpa. @RheumNow #EULAR2022 https://t.co/7Q3zxo7euj
Dr. Rachel Tate uptoTate ( View Tweet)
Nice session (joint chaired @AurelieRheumo) on AI in rheumatology - particularly from Michael Barnes on deciphering the polyome.
It's a whole door opened with insights beyond, but some careful steps necessary first (& cross-disciplinary footsteps to follow)
#EULAR2022 @RheumNow https://t.co/vLfDvcEnxo
David Liew drdavidliew ( View Tweet)