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Heart Risks Elevated in RA Patients Despite Biologic Tx

d MedPage Today

Hopes that biologic drugs for rheumatoid arthritis (RA) would cancel the extra cardiovascular risks normally seen with the disease dimmed a little in the face of findings from a population-based study from Scandinavia.

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The Effect of Socioeconomic Status on Lupus Outcomes

d Jack Cush, MD

Socioeconomic status (SES) often associates with poorer outcomes in systemic lupus erythematosus (SLE) patients; and a current study suggests this is unrelated to healthcare access issues.

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Tacrolimus Measures Up in Lupus Nephritis Trial

d MedPage Today

In a phase III trial, oral tacrolimus (Prograf) proved non-inferior to intravenous cyclophosphamide for treating lupus nephritis, researchers said.

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FDA Authorizes 2nd Booster for Older and Immunocompromised Individuals

d FDA

Today, the U.S. Food and Drug Administration authorized a second booster dose of either the Pfizer-BioNTech or the Moderna COVID-19 vaccines for older people and certain immunocompromised individuals.

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Differences in Biologic Persistence in Psoriasis and Psoriatic Arthritis

d Jack Cush, MD

Administrative claims analysis of biologic use in psoriasis (PsO) and psoriatic arthritis (PsA) in French health insurance databases shows that despite widespread biologic use, overall drug persistence (beyond 3 years) was low for PsO and PsA biologics.

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Japanese study using Mendelian randomization (MR) analysis of the association between coffee consumption, gout & uric acid levels - showing coffee consumption can causally reduce gout risk (OR = 0.50), independent of SUA levels https://t.co/ymovYj5y40 https://t.co/uI7OqY9FcU

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Study of 1899 ankylosing spondylitis pts(10 RCTs) shows TNFi resp can be predicted - 34% had major resp vs 34% w/ no resp @ wk12. A major resp increased w/ higher CRP, Pt Global & BASDAI-Q2 score & decr w/ higher BMI & BASFI https://t.co/DrT7EVcZi0 https://t.co/CcFicTM0Mo

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Your Lupus Questions from RNL 2022 Rheumatologists questions for Dr. Jack Cush QD Clinic is sponsored by RheumNow's PsA All the Way Campaign in April 2022 https://t.co/845D5KfUzY https://t.co/RtKopcTfiY

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Baricitinib Efficacy in Alopecia Areata https://t.co/6jYX5sPW44 https://t.co/Hvalig6U7V

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Your Rheumatoid Questions from RNL 2022 Rheumatologists questions for Dr. Jack Cush QD Clinic is sponsored by RheumNow's PsA All the Way Campaign in April 2022 https://t.co/sHBMKNvoXQ https://t.co/jcQgOIz7xt

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JAMA reports another study showing safety of COVID-19 vaccination during pregnancy with no incr in adverse pregnancy outcomes. Scand study of 157,521 births - 0.7%, 8.3%, 9.1% of were vaxD during 1st, 2nd, 3rd trimesters https://t.co/dZuabwr1Sf https://t.co/CtzMoEV1Ee

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Canadian population study shows that mRNA COVID-19 vaccination DURING 2nd &3rd trimester of pregnancy did not increase rate of adverse peripartum outcomes (vs no vax or vax post-Preg). Comparison of 97 590 Preg vs 44 815 non-preg https://t.co/n7nWcoLw4S https://t.co/uiVOg5A1S8

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Free Teaching PDF on "What is Rheumatoid Arthritis" from JAMA https://t.co/EGdq1jbjzJ

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Join us for Tuesday Night Rheumatology on April 5 at 7pm ET. Register today! https://t.co/ocaWwqB51x https://t.co/IPsf45UV0V

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Differences in Biologic Persistence in PsO and PsA Administrative claims analysis of biologic use in PsO and PsA in French health insurance databases shows that despite widespread biologic use, overall drug persistence was low for PsO and PsA biologics. https://t.co/PtrXu9xyFa https://t.co/RWciF4DqXj

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Metanalysis of 51 studies shows that chronic noninflammatory MSK pain is associated with impaired sexual function; compromised intimate relationships; and issues of sexual identity, body image, and self-worth https://t.co/VKHEMWiQZb https://t.co/OXhNSQF8Vc

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Study of 119 SLE pts (30 w CKD) shows urinary galectin-3 binding protein as a biomarker, increased w/ active LN, significantly (p<0.001)correlating w/ SLEDAI, SLICC RAS, histologic activity; higher in proliferative vs membranous LN (p=0.04) https://t.co/s8mRnfxIj6 https://t.co/s1OoiRy6Xi

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Adipokines are associated with CHF hospitalization (HR 1.39) & CVD-related death (HR 1.49) in #RA pts, especially in non-obese RA. This includes High leptin assoc w/ CV-death (HR 1.44) and High FGF-21 w/ lower CAD (HR 0.75) https://t.co/GQx1kzFOIJ https://t.co/M6MF73xPYs

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Mark your calendars! RheumNow is covering PsA this April. That means more Therapeutic Updates, Tuesday Night Rheumatology, Expert Blogs, and more. Join us April 1-30. https://t.co/b6OgsR8uxL
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A case–control study from Kaiser, compared obstetric complications in women who later developed Systemic Sclerosis (n=17) vs non-SSc controls (170). Obstetric complications higher in later SSc (71 v 50%) (HTN, PROM, IUGR, NICU, preterm births) https://t.co/4Y4eGuCFJi https://t.co/R4vw90bba4

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