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International Consensus on ANCA-Associated Vasculitis with Glomerulonephritis
Nephrology Dialysis Transplantation has published an overview of the management of anti-neutrophil cytoplasmic antibody associated vasculitis with glomerulonephritis based on several international guidelines, including those frorm the ACR 2021, EULAR 2022 and KDIGO 2021 (Kidney Disease: Improving
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ICYMI: Spondyloarthritis Innovations
The second day of RheumNow Live 2023 held in March ended with a focus on axial spondyloarthritis, especially on the evaluation of the definition of the disease, the inheritance of it, and of course the treatment of it.
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Peresolimab's Potential in Rheumatoid Arthritis
Peresolimab is a humanized IgG1 monoclonal antibody that acts as a PD-1 agonist (stimulator). The NEJM reports that PER met its efficacy primary endpont in treating patients with active RA.
https://t.co/B3tApMEWI3 https://t.co/Qi3WQkwvRd
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Medevil ruler Bermudo II ("The Gouty", in Spanish: "el Gotoso") was King of León & Galicia (982 to 999). Some campaigns were a success but he lost wars & reign, presumeably from severe gout & could no longer ride horseback, & had to travel by litter https://t.co/xxzRNUY2mv https://t.co/YQRwGixd4Y
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14 yr study #SLE (255 pts) & Lymphadenopathy. Causes: SLE (33.7%), lymphoma (0.8%) or TB (0.4%). LAD assoc w/ with fever (OR=3.3), pericarditis (4.1), membranous GN (3.6), leukopenia (2.6); NOT Wt loss, myocarditis, myositis. Bx needed to R/O lymphoma. https://t.co/WzCmtOVQWm https://t.co/rMEujVv9e2
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82 Patients with Knee OA and Severe Obesity, showed that Bariatric Surgery and Weight Loss Before TKA significantly Reduced Complications Versus TKA Alone (without Wt loss surgery). TKA was delayed 17 (vs 4 mos) in Wt loss group.https://t.co/JR3BUqthhy https://t.co/q93AI4cpK0
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In 2020, there were 619 million back pain cases Worldwide; this is expected to grown by 50% to 843 million people by 2050, due to ageing of populations.
https://t.co/ruB0gfMoFm https://t.co/UATKXRVj9p
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82 Patients with Knee OA and Severe Obesity, showed that Bariatric Surgery and Weight Loss Before TKA significantly Reduced Complications Versus TKA Alone (without Wt loss surgery). TKA was delayed 17 (vs 4 mos) in Wt loss group.https://t.co/JR3BUqthhy https://t.co/mUh5FfSUBR
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Dr. John Cush RheumNow ( View Tweet)
U.S. FDA Approves RINVOQ® (upadacitinib) as a Once-Daily Pill for Moderately to Severely Active Crohn's Disease in Adults based on induction studies, U-EXCEED, U-EXCEL,& U-ENDURE maintenance study. This is 7th FDA approval for RINVOQ https://t.co/DwU7L9A58i https://t.co/zeeiciPx01
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Dr. Spiera's approach to PMR treatment
- prefers methylprednisolone
- rapid taper over 16 weeks
- consider GC sparing therapy (MTX, IL-6i)
@Rheumnow #RNL2023 https://t.co/EtlDZm1RSb https://t.co/cZSYwYRKNM
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IL-6 for PMR
SPARE and SEMAPORE (Toci), SAPHYR (Sari)
2/2023: FDA approves sarilumab for PMR for inadequate response to corticosteroids or unable to taper off
Robert Spiera @RheumNow #RNL2023 https://t.co/gpBYXhguaV https://t.co/7tU1VBUb6F
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Cochrane metanalysis of antidepressant use in managing chronic pain shows they dont work, with the small exception, duloxetine - at standard dose (60 mg) it was effective, but no benefit to using a higher doses https://t.co/SReueTu4VV https://t.co/ki0snBMS3z
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"Ideally, you should get your TA biopsies within 2 weeks, but that's not always possible. Don't delay tx." @anisha_dua reminds us that bx can still be positive up to 8 weeks after steroid initiation. Just be aware of lesional changes with time. #RNL2023 https://t.co/uYBNrGzdQm https://t.co/Rvs0ewHzwb
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Allergic Drug - Induced Arthritis
Dr. Jack Cush reviews the news and journal reports from this past week on RheumNow. This week we delve into some odd associations, repeat drug warnings and the consequences of antirheumatic therapies.
https://t.co/AmpWG2Siii https://t.co/PwEgVHfDu8
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MSK Symptoms from Dupilimab, an IL-4/13 Inhibitor
A new MSK syndrome of inflammatory enthesitis/arthritis/tenosynovitis has been described in atopic dermatitis (AD) patients treated with the IL-4 receptor antagonist, dupilumab.
https://t.co/xGPSA2oRis https://t.co/y7M42DlM7d
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Brepocitinib in Active PsA
Brepocitinib is a novel tyrosine kinase 2/JAK1 inhibitor and has been studied in patients with moderately-to-severely active psoriatic arthritis (PsA), showing impressive efficacy at both 16 weeks and 52 weeks.
https://t.co/qzOVsLMkYe https://t.co/ouLyB131r8
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QD Clinic - Audience Vasculitis Questions from RNL23
Audience questions from the live RNL 2023 meeting and the session on EVOLUTION AND ADVANCES IN VASCULITIS held on March 18, 2023.
https://t.co/mvimbucTnd https://t.co/uJzkZcbNLa
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ICYMI: TNR - Vasculitis: Evolution and Advances
This is a replay from the live RNL 2023 meeting and the session on EVOLUTION AND ADVANCES IN VASCULITIS held on March 18, 2023.
https://t.co/OAI8NbSNes https://t.co/eDqqV9yZ9d
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TNF Inhibitors and Acne? A literature review found 47 refractory acne pts Rx w/ TNFi; noting partial improvement (94%) or clearance (40%) & only 6% w/ adverse events. 17 pts had new-onset acne after Rx w/ TNFi for a different inflamm Dx. Odd! https://t.co/duHEIHBMyK https://t.co/br8NQZQE2r
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The Schwartzman's (Monica and Sergio) discuss being in rheumatology as a family unit. We are so lucky in rheumatology to have many family connections! #RNL2023 @RheumNow https://t.co/hFbeGll2ut https://t.co/dfHnnbpNS8
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