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FDA Safety Update - Dr. Nadia Habal reviewed approval of Voclosporin, anifrolumab, Avacopen and approved new indications for multiple drugs #ACR21 https://t.co/lAgQ4d0h2m
Dr. John Cush RheumNow ( View Tweet)
FDA safety update: OA Stakeholder Workshop June 2021 - Congrats to FDA & AFfor tackling this LARGE unmet need- difficulty in determining benefit in OA (pain, structure, biomarkers?) -more research needed #ACR21 https://t.co/hCWU8OL0Le
Dr. John Cush RheumNow ( View Tweet)
FDA Update: 3 trials showing Efficacy of Tocilizumab in COVID 19:
1. RECOVERY - lower mortality
2. EMPACTA - Less progression to mech vent or death
3. REMDACTA & COVACTA - did not meet primary endpoints (but not contradictory) FDA Metanalysis of all 4 trials #ACR21 EUA 6/21 https://t.co/9yHu87KGej
Dr. John Cush RheumNow ( View Tweet)
FDA Update session: Proven Benefit of Baricitinib in Hospitalized COVID-19 from the ACT2 and COV-BARRIER Studies, showing it does not need to be given with Remdesivir (4 mg qd maz 14days) #ACR21 https://t.co/r6crPtu3ZH
Dr. John Cush RheumNow ( View Tweet)
FDA Update at #ACR21, Dr. Golding reviews the criteria for EUA - Emergency use authorization for new drugs (critically important during COVID-19) Session 8M115 https://t.co/DqmxEIdvWZ D https://t.co/6aQG8yP7RW
Links:
Dr. John Cush RheumNow ( View Tweet)
#ACR21 #Abstr1420 A study checking #COVID vaccine response in 90 #lupus pts and 20 HC:
⬇️Titres of Abs in SLE vs controls
💠Factors of poor response: On any DMARDs exc HCQ only (OR 15) and normal dsDNA
📢Important to pause DMARDs in stable SLE @RheumNow https://t.co/USovFkiCRb https://t.co/bn5CC0xRS9
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
Guselkumab improves anaemia in PsA. Appears to correlate with CRP response, ie inflammatory effect. Anaemia resolution associated good outcomes, but many with good outcomes still anaemic. Abstr#1331 #ACR21 @RheumNow https://t.co/LL63Qc0nk5
Richard Conway RichardPAConway ( View Tweet)
"Managing comorbidities can really improve outcomes for our patients"
@UnaMakris highlights the bio-psycho-social approach to multicomplexity and multimorbidity in our older patients with RA.
#ACR21 @RheumNow https://t.co/TMLqoreogZ
Mrinalini Dey DrMiniDey ( View Tweet)
#ACR21 Gift of Gab https://t.co/R1e14UA0pQ
Change habits through your words
⭐️Cost of inaction
⭐️Incremental change (ex ⬇️EtOH)
⭐️Follow the crowd!
⭐️Why not try?
Good advice for persuading pts re behavior change, Rx adherence, smoking cessation, vax hesitancy, etc. @Rheumnow https://t.co/9Cd7hAafTr
Links:
Eric Dein ericdeinmd ( View Tweet)
Pain can affect so many aspects of life; Dr. @unamakris noted that pain in older adults increase risk for:
👉falls/fracture
👉depression/anxiety
👉suicide
👉impaired nutrition
👉sleep disturb
👉mobility issues
👉cognitive deficits
👉frailty
👉spousal distress #ACR21 @rheumnow https://t.co/LicBiTRRKn
TheDaoIndex KDAO2011 ( View Tweet)
This is a reassuring introduction to Dr. Janet Zeide's lecture on the Gift of Gab! 😊
Might need to remind myself of this more regularly😉
@RheumNow #ACR21 @rheumarhyme #publicspeaking https://t.co/AoOmFkQUBk
sheila RHEUMarampa ( View Tweet)
Study on enthesitis response to biologic Rx
⭐️TNFI caused a 2❎ 🔽mean ActiveMASEI score compared to secukinumab
⭐️ 🔽PASI and DLQI score more in TNFI than Secukinumab
🔰Superiority of TNFi versus secukinumab in regards to active enthesitis
Abst#1356 #ACR21 @Rheumnow https://t.co/wdzMYmn8AJ
swethaann23 swethaann23 ( View Tweet)
Really love this slide from @UnaMakris on the "5Ms of #Ageing"- will be trying to apply this in the clinical setting.
📊#Multicomplexity
🧠#Mind
🚶#Mobility
💊#Medications
🎯#WhatMattersMost
#ACR21 @RheumNow https://t.co/bCQN4VpyBP
Mrinalini Dey DrMiniDey ( View Tweet)
#ACR21 Life hack! Hate public speaking? Wiggle your toes!
🔥Burn and redirect your adrenaline
🦆Like a duck's feet moving underwater, appearing calm on the surface
❌❌Janet Zeide: "Do not picture your audience naked!"
@Rheumnow
Eric Dein ericdeinmd ( View Tweet)
Dr Elliott presenting on US assessment of enthesitis with TNFi vs secukinumab. Surprisingly TNFi showed a more marked decrease in US enthesitis. Abstr#1356 #ACR21 @RheumNow https://t.co/XXgYMgkMyP
Richard Conway RichardPAConway ( View Tweet)
In a telemedicine world where you can't palpate joints virtually, how can we use pt self-joint counts well?
Patients & rheums might not always rate the same, but:
when RA pts say their joints are up or down,
rheum exam usually agrees👍
@earlyarthritis #ACR21 ABST1203 @RheumNow https://t.co/spUNTlMnDY
David Liew drdavidliew ( View Tweet)
📢#ACR21 #Abstr1421 Is #COVID19 vaccine safe and effective in #lupus? YES!! VOCOLUP study (N=1189 pts) showed:
💠~45% had a side-effect; of which 80% mild/moderate
💠Only 3% flared post💉(MSK + Fatigue); 10 required hospitalisation @RheumNow #ACRBest https://t.co/WF4aAfiX70 https://t.co/jc0HQoJymo
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
Waist:Hip ratio may be better than BMI in screening for obesity in #axSpA accdg to this study by @Sineadm15 & colleagues
👉⬆ prevalence of abdominal obesity in axSpA esp among ♀️
@RheumNow #ACR21 abs1322 https://t.co/UB3K7xR9kG
sheila RHEUMarampa ( View Tweet)
Fautrel describes a series of 13 #AOSD (Stills) pts with Pulmonary arterial HTN (cath confirmed) - seen exclusively with women, 85% and all were on DMARDs - 31% MTX, 69% IL-1i, all on steroids- 5 deaths, 3 yr Survival 74% (same as PAH) #ACR21 Abstract 1100 https://t.co/qR21MdYG3A https://t.co/WN38ifgtT6
Links:
Dr. John Cush RheumNow ( View Tweet)
Been looking forward to this session on #multicomplexity in the ageing patient with #rheumatoidarthritis- particularly enjoying the case-based format!
#ACR21 @RheumNow https://t.co/9SN3bjbfTc
Mrinalini Dey DrMiniDey ( View Tweet)