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#ACR21 'Gift of Gab' @RheumNow https://t.co/HUITnJMB33
David Liew drdavidliew ( View Tweet)
Guselkumab (IL23p19 inhibitor) positive effect on axial outcomes in PsA, durable response across 2 years. Abstr#1330 #ACR21 @RheumNow https://t.co/8LOSdzCvRc
Richard Conway RichardPAConway ( View Tweet)
One of the most provocative & interesting abstracts the GCA space at #ACR21 -so many sides to consider- I will be discussing at @RheumNow Panel w @drdavidliew WEDS AM @AdamJBrownMD @CCalabreseDO @CleClinicMD #vasculitis @EBRheum @anisha_dua https://t.co/STR9gNPdsO
Leonard Calabrese LCalabreseDO ( View Tweet)
A meta-analysis of 5 cohort studies showed that PsA is significantly associated with vertebral fractures pooled OR 2.09 (95% CI, 1.11 – 3.96; I2 70%). The review was not suggestive of publication bias
@RheumNow #ACR21 Abst#1304 https://t.co/rjC776FXUA https://t.co/QvMWxN6ZZ7
Dr. Antoni Chan synovialjoints ( View Tweet)
#ACR21 Abst#1205- Discordance bw pt and MD global assessment in RA?
⭐️15% discordance (>30 mm difference in GA score)
⭐️⬆️ in LDA and mod disease, ⬇️ remission/high disease
⭐️♂️ sex, pain VAS, normal CRP, less TJC&SJC predictive
@Rheumnow https://t.co/N2qAaDiBE5
Links:
Eric Dein ericdeinmd ( View Tweet)
Dr Heckert presenting data from BEST study showing that RA tends to recur in same joints. Recurrence in 46% of joints with baseline swelling. Baseline swelling predicts recurrence OR 2.37 Abstr#1216 #ACR21 @RheumNow https://t.co/KxjHkkc6aB
Richard Conway RichardPAConway ( View Tweet)
In one institution, 25% of Crohn's patients had abnormal SI findings on MRE/MRI. Majority without back pain, were female with intestinal complications.
Abs#1306
#ACR21 @RheumNow
https://t.co/z8Yvc98s67
Robert B Chao, MD doctorRBC ( View Tweet)
Young patients with #SLE #lupus have a #multimorbidity burden similar to individuals 30years older than them.
A high #comorbidity burden is present in SLE pts of all ages compared to non-SLE.
How can we address this?
Abs#1049 #ACR21 #ACRBest @RheumNow
https://t.co/U6t8YBFUZz https://t.co/v7Fwof1gZc
Mrinalini Dey DrMiniDey ( View Tweet)
#ACR21 Abs#1210: Frequency of anterior atlanto-axial sublux in RA
⭐️Anterior atlanto-axial subluxation (aAAS) = 3+ mm, frequency = 25%
⭐️Radicular pain 20%, surgery 6%
▶️Longer disease duration, ⬆️ frequency of extra-articular manifestations
https://t.co/BfjCTlRJbt @Rheumnow https://t.co/xd9h5e9cDH
Links:
Eric Dein ericdeinmd ( View Tweet)
Meta-analysis shows increased risk of vertebral fracture in PsA, OR 2.09. Abstr#1304 #ACR21 @RheumNow https://t.co/kTrR7I3HA0
Richard Conway RichardPAConway ( View Tweet)
Psoriasis can be diagnosed at any time of axSpA follow up.
Incidence of PsO ⬆️from 16.8% to 26.8% after 6 years
Patients with PsO had more peripheral arthritis and higher BMI
Abs#1311
@RheumNow
https://t.co/IrvHiFqr2m https://t.co/lqCVcF81zA
Robert B Chao, MD doctorRBC ( View Tweet)
#clinicalpearls Cervical involvement in RA: is it underestimated? Cohort of 240pts: anterior atlantoaxial subluxation (aAAS) found in n=25 10.4 % patients, 1/3 with no neck pain! Joint restriction OR: 5.8 hx arthroplasty OR:3.6
#Abst1211 #ACR21 @RheumNow
https://t.co/KRkDP4ETMu https://t.co/soKTMPiMwy
Aurelie Najm AurelieRheumo ( View Tweet)
#RA pts on #baricitinib less likely to discontinue treatment & more likely to achieve remission than pts receiving biologic /other tsDMARD.
👉🏼Results from RA-BE-REAL observational study
👉🏼Bari(2 or 4mg) vs biologic/other tsDMARD
Abs#1223 #ACR21 @RheumNow
https://t.co/WRN1OCX9Bq https://t.co/UCFF6hAY7G
Mrinalini Dey DrMiniDey ( View Tweet)
In 🇦🇺 we're delighted to be working with @Sarah_L_Mackie et al on the STERLING-PMR trial:
- relapsing PMR
- pragmatic RCT
- MTX (alt LEF)
🇬🇧 @NIHRresearch @LeedsBRC
@profbdasgupta @DrMaxYates1 et al
🇦🇺 @nhmrc
@CatherineL_Hill @helenkeen73 @drceowen
#ACR21 PMR/GCA SG @RheumNow https://t.co/YtnPpHxNqz
David Liew drdavidliew ( View Tweet)
Peripheral and axSpA pts with low Vitamin D levels (<30) had worse disease activity and functional impairment (BASDAI, ASDAS, BASFI) compared to pts with normal Vit D levels.
Abs#1316
#ACR21 @RheumNow
https://t.co/ulIqOAnWtp https://t.co/aMQaTpduJK
Robert B Chao, MD doctorRBC ( View Tweet)
@Sineadm15 @bososhea on undiagnosed depression in axSpA. Common, and associated with worse disease activity and quality of life. Abstr#1305 #ACR21 @RheumNow https://t.co/PBH1F3XEGv
Richard Conway RichardPAConway ( View Tweet)
#ACR21 Abs#1224. ⬇️ CD39 expression on B cell predicts occurrence of anti-drug Ab in RA on RTX
⭐️13/23 pts on RTX became ADAb+. No diff in concomitant MTX usage
⭐️Baseline CD73 similar, but lower CD39 predictive of ADAb
https://t.co/QzbAmXtTmZ @Rheumnow https://t.co/CLtEev69YD
Links:
Eric Dein ericdeinmd ( View Tweet)
Minimal disease activity achievement in PsA achieved by 22.8% in 6 mo of b/ts DMARD
MDA achievers were:
➡️Younger
➡️🔽 Disease duration;
➡️ Male
➡️Non-obese
➡️bDMARD-naïve at baseline
➡️🔼 probability achieving MDA components➕MCID PROMs at 6 mo
Abst# 1344 #ACR21 @Rheumnow
swethaann23 swethaann23 ( View Tweet)
Effect of BMI on PRO treatment response in PsA. Increasing BMI associated with lower response. More pronounced in TNFi than IL-17 or JAKi. Abstr#1327 #ACR21 @RheumNow https://t.co/qhgVlW72uM
Richard Conway RichardPAConway ( View Tweet)
In this study,
⭕AS pts w/>=2 #comorbidities were associated w/ poorer outcome measures after 2 yrs of ffup vs. pts w/ no comorbids
⭕Pts w/ >=2 comorbids were likely to dc 1st anti-TNF
Address comorbidities, ⬆ chances of better outcomes & QoL
@RheumNow #ACR21 abs1309 https://t.co/sTnjaC1a1l
sheila RHEUMarampa ( View Tweet)