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Bridging the gap in the delayed diagnosis of axSpA

d Swetha Ann Alexander, MD

Delay in the diagnosis of axial spondyloarthritis (axSpA) has been a huge challenge and is associated with poor outcomes.

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Cathepsin K - has some promise in Knee OA - now going to Phase 3 @RheumNow https://t.co/exUFqcCJy1
Bella Mehta bella_mehta ( View Tweet)
NORD-STAR Trial: outcomes in tx-naïve, early RA pts after 48w of csDMARDs+GC vs bDMARD (ABAtacept, CerToliZumab, or ToCiluZumab)+MTX ➡️ Superior CDAI remission rates w/ ABA+MTX & CZP+MTX but not TCZ+MTX vs csDMARD+GC ➡️Imaging progression low in all Abst#0825 #ACR21 @RheumNow https://t.co/QaFIF4WNEG
Meral K. El Ramahi, MD MeralElRamahiMD ( View Tweet)
#ACR21 #Abstr0871 📢Argument against HCQ<5mg/kg dose from cardiac perspective in #lupus. A retrospective study N=296 pts, 13% developed CV events.⬇️28% in risk of heart failure, arrhythmia/cardiac death per mg/kg of HCQ in non-smokers @RheumNow #ACRBest https://t.co/6ssd2159R1 https://t.co/tllPWLnFFj

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Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
@SteliosTomaras @RichardPAConway @drhectorchinoy @RheumNow EMG/NCS can help uncover various neurological disorders including muscle dystrophies. Obviously it depends on center and expertise. Both MRI and EMG are useful and have different complementary utilities in Myositis. Many centers are not able to perform or interpret MRI reliably.

Rohit Aggarwal docrota ( View Tweet)

@KatGilekMD @RichardPAConway @RheumNow @drhectorchinoy EMG/NCS can help uncover various neurological disorders including muscle dystrophies. Obviously it depends on center and expertise. Both MRI and EMG are useful and have different complementary utilities in Myositis. Many centers are not able to perform or interpret MRI reliably.

Rohit Aggarwal docrota ( View Tweet)

Abs#0494 was presented yesterday in the #HealthDisparities abstract session. Here's my video summary of this important work on #socialdeprivation and access to care. #ACR21 @RheumNow https://t.co/AzBw2XpMzr

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Mrinalini Dey DrMiniDey ( View Tweet)

@NU_Rheum_MSK_US @RichardPAConway @drhectorchinoy @RheumNow Muscle ultrasound can be very useful but it is not ready for prime time currently to be used to do muscle biopsies. Perhaps in few years once we know how to target the muscle for biopsy.

Rohit Aggarwal docrota ( View Tweet)

@DrAshleyYip @RichardPAConway @drhectorchinoy @RheumNow EMG/NCS can help uncover various neurological disorders including muscle dystrophies. Obviously it depends on center and expertise. Both MRI and EMG are useful and have different complementary utilities in Myositis. Many centers are not able to perform or interpret MRI reliably.

Rohit Aggarwal docrota ( View Tweet)

⭐️RA pts w/ high adipokines (fat-secreted proteins) have lower rates of LDA + remission independent of b/l dz activity & BMI ⭐️↑ adipokines esp adiponectin, then more likely to need b/tsDMARD ➡️Adipokines may be prognostic biomarkers 4 refractory dz. Abst#0789 #ACR21 @RheumNow https://t.co/AFT22TzTFp
Meral K. El Ramahi, MD MeralElRamahiMD ( View Tweet)
Marc Hochberg lecture at #ACR21 - Bisphosphonates limited and inconclusive data in radiographic progression of OA, some ⬇️ in bone marrow lesions! @RheumNow https://t.co/ciMUINBLwm
Bella Mehta bella_mehta ( View Tweet)
Abst 0981 Interesting study by Singer & colleagues examining economical and clinical burden of herpes zoster in patients with RA - RA + HZ --> higher odds health resource utilization - RA + HZ --> higher costs $$$ #ACR21 @RheumNow https://t.co/6Oc7ymbKHQ
Akhil Sood MD AkhilSoodMD ( View Tweet)
TOFA Post hoc analysis on 2000pts: ⬆️ Paraoxonase PON1 activity associated w/ ⬇ risk of malignancies (not NMSC) in RA pts treated w/ TOFA, Adj on RA duration, age, and smoking. A promising biomarker! #Abst980 @RheumNow #ACR21 https://t.co/fOILnAyDN9
Aurelie Najm AurelieRheumo ( View Tweet)
Real-world data shows no difference between genders in effectiveness of secukinumab in #AnkylosingSpondylitis, for disease activity, global functioning and severity of depression. #Abs0909 #ACR21 @RheumNow https://t.co/2n6Y5ZB1Ot https://t.co/zIMEzHBUrh

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Mrinalini Dey DrMiniDey ( View Tweet)
Dr. Marc Hochberg delivering the Oscar Gluck Memorial lecture - His talk titled "The Role of Bone in OA". He begins with this statement.... "DJD... Should never be used" - the rest of the lecture explains why. #ACR21 https://t.co/lYGsFu4Wpr https://t.co/IWP5J73mFO

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Dr. John Cush RheumNow ( View Tweet)
#Abs0588 Effectiveness of TNFi vs non-TNFis in obese patients with #rheumatic disease @MilenaGianfran: 👉🏼>16000pts @ACRheum RISE 👉🏼Abatacept➡️larger decreases in CDAI in obese pts 👉🏼Tocilizumab➡️larger decreases in CDAI in non-obese pts @RheumNow #ACR21 https://t.co/bL5xnG1iNh

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Mrinalini Dey DrMiniDey ( View Tweet)

B cell repertoire: the new 🔮? An algorithm associating baseline CDAI to BCR sequencing outcomes w/ ✨Isotypes frequency ✨Somatic Hypermutations predicts MTX 12mo response w/ 78% sens & spe #Abstr982 #ACR21 @RheumNow https://t.co/SZaip6xUaO https://t.co/fbWq34gtzc

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Aurelie Najm AurelieRheumo ( View Tweet)
Dusting off the old emergency supply right now (and there’s a lot of dust). See? It said it on the side of the bottle all this time… they knew. #ACR21 ABST0957 @RheumNow https://t.co/ygw6BkkjEp https://t.co/DqbIP8uL68

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David Liew drdavidliew ( View Tweet)
Does #comorbidity burden affect treatment of #InflammatoryArthritis? Abs#0577 #ACR21 👉🏼~6500pts; 11 types of IA 👉🏼Higher comorbidity burden➡️more likely to receive steroids than TNFis 👉🏼Are patients w/ IA & multiple comorbidities receiving suboptimal therapy? @RheumNow #ACRBest https://t.co/iIERb0wL4Y
Mrinalini Dey DrMiniDey ( View Tweet)
Stop by the RheumNow booth! #ACR21 #RheumPix https://t.co/e9dEwkfXU9
Dr. John Cush RheumNow ( View Tweet)
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