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Taking CAR-T for a Test Drive
When the ACR Convergence 2024 abstract site went live, the first query I typed into the search bar was, “CAR-T.” I consider myself a CAR-T skeptic and would be surprised if the magical results from this NEJM case series replicate at scale, but it seems likely that CAR-T will revolutionize the care for (some) patients with rheumatic diseases. What new data will be presented at ACR?
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Are Emulation Trials a Fantasy?
Are emulation ‘trials’ helpful, despite the biases that occur with observational data, or do they truly mimic the results of randomized controlled trials (RCTs)?
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#Blinded by results? 😊
#Ocular #involvement in #GPA
👇
Helped by #rituximab
👁️ #GPA
Difficult
Proptosis
Pseudotumour
Conjunctivitis
Scleritis
Vasculitis
Ocular muscles - diplopia
Small case series ‘author defined’ remission in
80% 👍 #RTX
#abst0726 @rheumnow #ACR24 https://t.co/GHptelOTyv
Janet Pope Janetbirdope ( View Tweet)
@ACRheumDC
Check out the ACR policy position statements
Created by volunteer-led, non-partisan group of GAC committee - changes based on the needs of the ACR members
@cdowneymd
https://t.co/oAFfYUct4y
@RheumNow #ACR24 https://t.co/MmVd8XYs0j
Links:
Eric Dein ericdeinmd ( View Tweet)
If you are not at the table, you are on the menu
https://t.co/c4anIn3aue
@cdowneymd @ACRheumDC
Join a committee
RheumPAC
Write a letter
Write a post card at ACR Hub at #ACR24
Advocacy office hours with ACR staff
#Act4Arthritis & Advocacy 101 on Cap Hill
@RheumNow https://t.co/bpilydxEpB
Links:
Eric Dein ericdeinmd ( View Tweet)
@LennMcD @ACRheumDC
Current congress (118th) - very tight margins, paralyzed by the ‘24 elections. Now in lame duck
Many ACR policies made into bills - PA, step rx, copay accumulator, workforce, loan repayment, incr Rx transparency
Needs to be passed into law
@RheumNow #ACR24 https://t.co/1elEUiUAmh
Eric Dein ericdeinmd ( View Tweet)
@DrLauraCoates presented Sex differences in clinical presentations of PsA:
-Women present >polyarthritis, enthesitis and worse PROs which translates to ⬆️ DAPSAs in spite of less Rx progression.
-Men more oligoarthritis, axial involvement, higher skin disease.
#ACR24… https://t.co/iapZF0nZWX https://t.co/jZ79WfxZwh
Links:
Adela Castro AdelaCastro222 ( View Tweet)
@LennMcD
@ACRheumDC
Many ACR priorities in bills, needs to be passed in law
Victories:
Incr NIH biomedical research funding, added to DoD funds
Medicare reimbursem and telehealth needs addressed by lame duck congress
Get involved, reach out, write letters
@RheumNow #ACR24 https://t.co/7oCvUFWpx4
Links:
Eric Dein ericdeinmd ( View Tweet)
"We look forward to Carol Langfords upcoming leadership at ACR and its newfound focus on ANCA vasculitis as the most important disease" 😆😂
-Phil Seo
#ACR24 @RheumNow
Mike Putman EBRheum ( View Tweet)
Starting soon:
Room 152A
@ACRheumDC @cdowneymd @BelindaBirnbaum
What does the election and current political changes mean for rheumatology?
How does ACR play a role in supporting you? What are the easy steps you can do?
#ACR24 @RheumNow https://t.co/jTtk80RdqI
Eric Dein ericdeinmd ( View Tweet)
Thrilled to have my abstract accepted for poster presentation at #ACR24 with @rheumarhyme
Drop by abs1314 to know more 🤓
#HPEd #educator #telerheumatology
@Rheumnow https://t.co/j2rZLGm7lA
sheila RHEUMarampa ( View Tweet)
Managing DMARDs in pregnancy. Curbside consults by Lisa Sammaritano @RheumNow #ACR24 https://t.co/FQrLNz4yCz
Antoni Chan MD (Prof) synovialjoints ( View Tweet)
RheumNow’s expanded coverage of the #ACR24 annual meeting is sponsored in part by Novartis. All content is chosen by RheumNow & its faculty.
Dr. John Cush RheumNow ( View Tweet)
In the @ACRheum MSK Ultrasound Guidance:
In difficult-to-treat RA, MSUS can distinguish symptoms of active synovitis from other sources of pain.
(consensus: mod)
CURRENTLY do you often use ultrasound when RA gets difficult to treat, and synovitis isn't obvious? #ACR24 @RheumNow
David Liew drdavidliew ( View Tweet)
Phase 2 DBRCT of daxdilimab, an immunoglobulin-like transcript 7 to target plasmacytoid dendritic cells
No difference in primary outcome... but kiiiinda looks like something there?
I dislike Phase 2's; should go straight to Phase 3 if able
#ACR24 @rheumnow Abstr#1542 https://t.co/osDWDskfnA
Links:
Mike Putman EBRheum ( View Tweet)
@KDAO2011 help me out here; what is the point of analyses like this?
NO difference in PROs comparing voclo vs plbo...
...but if you split by responder status its different
Prescribing the drug doesn't help PROs, but when it works it works? 🤔
#ACR @RheumNow Abstr#1538 https://t.co/339drHwUuK
Mike Putman EBRheum ( View Tweet)
Remote monitoring SHOULD increasingly be part of our care. BUT I don't think it neccessarily will. Just like with conferences reverting to non-virtual when facilitating virtual is logical from a learning perspective. There are other limiting interests in play #ACR24 @RheumNow https://t.co/UN3jGa7jVZ
Richard Conway RichardPAConway ( View Tweet)
One situation I've seen MSK ultrasound have impact ++ in the real-world is showing patients their own RA disease activity.
Arthritis might be the invisible disease sometimes, but seeing it in full Doppler colour on screen means a lot to many.
#ACR24 MSK USS Guidance @RheumNow https://t.co/wd9s6FAfp4
David Liew drdavidliew ( View Tweet)
A framework for critical conversations with patients
(because the big decisions deserve high quality counselling, otherwise the consequences are real)
#ACR24 16S17 @RheumNow https://t.co/fiwYY1DuMq
David Liew drdavidliew ( View Tweet)
"Do not fear RPF." - John Stone
Retroperitoneal fibrosis certainly feels challenging at times, and radiologic features might stay even after functional improvement
but we've come a long way
(although, despite B cell depletion, there's plenty more to do)
#ACR24 16S26 @RheumNow https://t.co/2Y3buXrAFY
David Liew drdavidliew ( View Tweet)
