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My typo: * patience (but "patients" are needed too for a rheum career)
TheDaoIndex KDAO2011 ( View Tweet)
Drs. Alarcon, Hajjaj-Hassouni, Aggarwal, and March are trailblazers for #WomeninRheum. Sage advice: "The people who open doors may be you." "Sometimes, you have to create your own opportunity." "Push your ideas, don't just watch." #ACR21 @acrheum
@LauraLewMad11 moderates panel https://t.co/gxmjntDQst
TheDaoIndex KDAO2011 ( View Tweet)
Dr. P Krause (FDA/CBER Deputy Dir., Office of Vaccine Research and Review) on #COVIDvaccine in kids:
👉Children respond to vaccine better than adults; can use lower doses
👉the lower dose will mitigate safety concerns
(FDA gave EUA for Pfizer vaccine for 5-11 yo) #ACR21 https://t.co/Z7kcYQKZ8S
TheDaoIndex KDAO2011 ( View Tweet)
RheumNow’s expanded coverage of the #ACR21 meeting is sponsored in part by @Novartis. All content chosen by RheumNow & its Faculty.
Dr. John Cush RheumNow ( View Tweet)
👉 anti-CK Ab may be a cause of #LongCovid syndrome
👉found in patients with autoimmune (SLE/Sjogrens) and can affect dz severity.
👉has not been seen in children
2/2
#ACR21
TheDaoIndex KDAO2011 ( View Tweet)
Role of anti-CK antibodies:
👉⬆️susceptibility to severe mycobacterial dz & opportunistic infx (similar to HIV)
👉causes an indeterminate quantiferon (no response to mitogen)
👉initiated by infx➡️anti-Noc2 Ab➡️cross react with IFN➡️IFN-Ab
👉⬆️severity of #COVID19 #ACR21 1/2 https://t.co/5NHQpwQw6X
TheDaoIndex KDAO2011 ( View Tweet)
“At the end of the day, the one treatment that will save the most lives will be the vaccines. That’s the homerun!”
– Dr. R Cron, pediatric rheumatologist on reviewing treatments for hyperinflammation and #COVID19 @UABRheum #ACR21 #VaccinateOurKids https://t.co/dL1buLkMkM
TheDaoIndex KDAO2011 ( View Tweet)
In case you missed it. @ACRheum #COVIDvaccine guidance v 4.0 for Rheum patients & what's added:
👉3rd dose recommend, timing relative to meds (as before)
👉mRNA booster preferred if initial doses were mRNA
👉mAb as PrEP/Rx for high risk pts
https://t.co/R8K8WeZBMt
TheDaoIndex KDAO2011 ( View Tweet)
answer: CPPD.
👉CPPD can look like OA but can be more aggressive.
👉Look for chondrocalcinosis at the triangular ligament, pubic symphyis, superiolateral femoral head
👉A common cause of scapholunate widening
👉CPPD loves the patellofemoral joint (knee joint may be spared) https://t.co/wgYjJwYvb0
TheDaoIndex KDAO2011 ( View Tweet)
DECT (dual energy CT) very helpful to distinguish gout from other crystals and give volumetric measurements using color-coded images... So do we need to do arthrocentesis to diagnose gout anymore? #ACR21 https://t.co/kn2IpXP870
TheDaoIndex KDAO2011 ( View Tweet)
Pearls on gout:
👉Gouty tophi can appear in the L spine and destroy the facet joints
#ACR21 Radiology Bootcamp with Dr. Brindle. https://t.co/ml2uI9f10v
TheDaoIndex KDAO2011 ( View Tweet)
Ouch! Patients with AS can fracture with minor trauma
#ACR21 Radiology Bootcamp https://t.co/1piKvKUM2w
TheDaoIndex KDAO2011 ( View Tweet)
#ACR21 Radiology Bootcamp-- pretty helpful if you're studying for #ABIMRheumBoards
Do you know how to distinguish sacroiliitis from pseudo-sacroiliitis? https://t.co/btS8mm8yH8
TheDaoIndex KDAO2011 ( View Tweet)
👉Get contrast if ordering an MRI to eval for inflamm. arthritis
👉Heel spur vs. enthesitis? Look for erosions at dorsum of calcaneus & other signs of inflamm
👉DISH vs. axial PsA? DISH➡️contiguous bony ossific'n up anterior margin of the vertebral bodies; PsA not cont.
TheDaoIndex KDAO2011 ( View Tweet)
Delighted to be reporting for @RheumNow from #ACR21 with @KDAO2011 @Yuz6Yusof @drdavidliew @Janetbirdope @uptoTate @AurelieRheumo @ericdeinmd @doctorRBC @synovialjoints @MeralElRamahiMD @DrMiniDey @_Castillo_Pedro @DrPetryna @AkhilSoodMD @swethaann23 @RHEUMarampa Follow them all!
Richard Conway RichardPAConway ( View Tweet)
The future according to Dr. M Brenner?
👉Bioengineered cells to treat inflammation.👈
#BasicScience #YearInReview #ACR21 @rheumnow https://t.co/EgoYBEZgT0
TheDaoIndex KDAO2011 ( View Tweet)
#GreatDebate: add belimumab (BLMB) vs. voclosporin (VCS) to MMF for lupus nephritis (LN)
Dr. Petri argues for BLMB b/c: (1/2)
👉improvement in LN
👉improvement in non-renal lupus
👉decrease lupus renal mortality
👉**prevent GFR reduction **
👉long term efficacy
#ACR21 @rheumnow
TheDaoIndex KDAO2011 ( View Tweet)
KEEPsAKE trial 1 (DMARD-IR) and 2 (DMARD/biologic-IR) on risankizumab (IL23i) for PsA:
👉some benefits of risankizumab for axial disease
👉no data regarding bowel disease
👉pts did remain on background DMARDS, steroids.
(2/2)
TheDaoIndex KDAO2011 ( View Tweet)
Abst#0858 Hopkins SLE Cohort 860 pts, 65 w/COVID19, 228 vax'd:
👉COVID19 infx did not increase dz activity, but aPLs were increased (rash decreased likely d/t quarantine and no sun exposure)
👉COVID19 vaccine did not affect dz activity #ACR21 @rheumnow
https://t.co/C65qJuMIbk
TheDaoIndex KDAO2011 ( View Tweet)
Pearls esp important for older patients #acr21:
👉🏻social isolation and or social context makes a big difference in accomplishing #goals and achieving #whatmattersmost
👉🏻encourage and motivate patients to engage someone in their community #nudge @CreakyJoints @ArthritisFdn
Una Makris UnaMakris ( View Tweet)