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Emerging Therapies in Spondyloarthritis: A Promising Pipeline

d Olga Petryna, MD

Growing awareness of spondyloarthropathies over the last two decades has led to a better understanding of the pathophysiology of spondyloarthritis, and subsequently increased interest in more distinct, disease state specific treatment options.

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GCA temporal artery

Novel treatment options for Giant Cell Arteritis

d Richard Conway, MBBChBAO, PhD

Giant cell arteritis is associated with significant treatment related morbidity due to the dependence on glucocorticoids as a treatment option. After sixty years of therapeutic stagnation, these are exciting times in the management of GCA. At this year's ACR Convergence meeting, encouraging data will be presented on options for GCA.

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How can behavioral therapy help people manage #ChronicIllness? @AftonHassett mentions these at #ACR21: - Psychiatric comorbidity - Pain catastrophizing - Fear avoidance - Limited coping skills - Poor sleep - Physical inactivity https://t.co/1c8bThYNP0
CreakyJoints.org CreakyJoints ( View Tweet)
And I’m finally in the game!! On board for #ACR21 Enjoying hearing Virginia Pascal showing data on how opsonisation of red blood cells containing mitochondria results in the induction of Type I Interferon pathways Great paper here https://t.co/QWJLncYmC3 #ACRambassador

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Chris Wincup chriswincup ( View Tweet)

#ACR21 - Dr. Virginia Pascual speaking on #PrecisionMedicine in Lupus. Mitochondria in RBC's will cause more disease activity in Lupus patients. Th groups that remove Mitochondria have less disease activity. Hope this takes us to #precisionmedicine soon!. #Looms4Lupus https://t.co/sMOmeJPMJX
Looms4Lupus Looms4Lupus ( View Tweet)
So fitting that @ACRheum President @DrDavidKarp has highlighted the amazing work of @rheum_covid in the #ACR21 Opening Session. In crazy times, it delivered results with unprecedented speed, when our patients needed it most. We will look back in history with thanks. @RheumNow https://t.co/cTnAZP9UDl
David Liew drdavidliew ( View Tweet)
It's all happening for biologic therapies in PMR! phase 2/3 double-blind RCT: - new PMR - n=36 - 11w PNL taper (until relapse - clinical not lab) - weekly sc TCZ for 16w vs placebo big benefit persists post-TCZ cessation real steroid sparing PMR-SPARE #ACR21 ABST0507 @RheumNow https://t.co/w8tgOPAtyJ
David Liew drdavidliew ( View Tweet)
Dr B Bermas noted AAP guidelines say avoid MTX while breastfeeding, but the literature show very little MTX crosses breast milk. Dr Sammaritano stated that is true, but we don’t know how much MTX accumulates,though. #acr21 @rheumnow @UTSWRheum https://t.co/9I7HszorEO
TheDaoIndex KDAO2011 ( View Tweet)
Would you allow a pt to continue MTX while breastfeeding? #acr21 @rheumnow

TheDaoIndex KDAO2011 ( View Tweet)

Abst 0501 Kakkar & colleagues examined immunogenicity of single dose of SARS-CoV-2 Vaccine in patients with systemic sclerosis - Vaccine is safe - Immunosuppression lowered Ab production but no effect on T cell response #ACR21 @RheumNow https://t.co/NsLrWHh7ZS
Akhil Sood MD AkhilSoodMD ( View Tweet)
In GCA, why might you target GM-CSF over IL-6? Entirely plausible TCZ might be leaving some Th1 stones unturned, esp: vascular remodelling downreg pathways Transcriptomics from toci/mavri-treated TAB show it's plausible beyond just theory... Cid group #ACR21 ABST0506 @RheumNow https://t.co/YephlzHOdj
David Liew drdavidliew ( View Tweet)
VEXAS a new genetic disorder, (V) Vacuoles, (E) E1-enzyme, (X) X-linked, (A) Autoinflammatory, (S) Somatic. These are the important clinical features to be looking out for in clinic @RheumNow #ACR21 Session6S410 L Wilson, DO Cordona https://t.co/dBBLox6vVg
Dr. Antoni Chan synovialjoints ( View Tweet)
#LongCovid management #ACR21 #CDC 🔴Multidisciplinary approach: Holistic management 🟢Arthralgias" NSAIDs 🟢Brain fog: cognitive training 🟢 Anosmia/ dysgeusia: olfactory training 🟢 Fatigue: Exercise 🟢 Anxiety/ Depression/ PTSD: psychotherapy #ACRambassador https://t.co/dB1OHlO0bl
Nelly ZIADE 🍀 Nellziade ( View Tweet)
Excellent session on COVID-19 update on therapeutics chaired by @rheum_cat Prof. Luis Ostrosky outlining the therapies at different phases of COVID-19 including antivirals, convalescent plasma, anticoagulation, exercise and long-term endemic phase @RheumNow #ACR21 Session6S424 https://t.co/jso7x1v1oA
Dr. Antoni Chan synovialjoints ( View Tweet)
IL-18 in autoinflammatory Disorders session talk by Raphaela Goldbach-Mansky - Discovered in 1995 - IL18 expressed in epithelial cells, keratinocyts, macrophages - IL-18R neg regulated by IL-18 binding protein https://t.co/U6TTDqEb7L https://t.co/R2lIo188ac

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Dr. John Cush RheumNow ( View Tweet)
Round up of the QD Clinics for the last week, now available. #ACR21 QD153 - Serologically Active, Clinically Quiescent SLE QD154 - Paradoxical Psoriasis QD155 - Scary Steroids QD156 - How I Treat Rheumatoid Arthritis https://t.co/MLimMt4bW0 https://t.co/Afs117eY7t

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Dr. John Cush RheumNow ( View Tweet)
It is always difficult to distinguish infection and disease flares in autoinflammatory syndromes = 25 pt sJIA study at #ACR21 showing serum procalcitonin levels are useful when >0.95ng/ml @StillsDis_411 @rheumnow #abst0252

Bella Mehta bella_mehta ( View Tweet)

Abst # 0494 Dowell & colleagues showed that in RA patients using RISE registry - disease activity correlated with burden of comorbidities - this was linked to areas of low SES (ADI > 80) who received primarily Medicaid Coverage https://t.co/xkdVnieHB2 #ACR21 @RheumNow https://t.co/jyZbV64qVz

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Akhil Sood MD AkhilSoodMD ( View Tweet)
#ACR2021 Dr. L Sammaritano shows evidence for using belimumab during breastfeeding @RheumNow https://t.co/kDXXauoOZQ
Donald Thomas, MD lupuscyclopedia ( View Tweet)
Contraceptive methods available for pts, avoid estrogen in +aPL or active SLE #acr21 @acrheum reproductive guidelines @rheumnow https://t.co/dNfSyqjWKc
TheDaoIndex KDAO2011 ( View Tweet)
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