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Serum IL-22 levels elevated in axSpA pts in Israeli study. Possible independent biomarker for the differentiation of AxSpA from its non-inflammatory mimickers? Possible target for treatment? Further studies needed. Abs 0385 #ACR21 #RheumNow @RheumNow https://t.co/AUwZFJTlnq https://t.co/WSZ2WjW45W
Dr. Rachel Tate uptoTate ( View Tweet)
Can we stop RA developing? Not previously.
Double-blind RCT:
- arthralgias+ACPA+MRI changes
- but no clinical synovitis
- abatacept for 6m
didn't progress to arthritis: 92% v 65%
improvement in MRI: 61% v 31%
+ benefit to 18m not shown
"provocative"!
#ACR21 ABST0455 @RheumNow https://t.co/TGxCBhk4r9
David Liew drdavidliew ( View Tweet)
New treatments in #psoriaticarthritis Deucravacitinib TYK2 inhibitor selectively mediates cytokine signaling, specific inflammatory pathways (eg, IL-23, IL-12, and Type I interferons) concomitant with clinical symptom improvement @RheumNow #ACR21 Abst#0490 https://t.co/7JZGa5R4eC
Dr. Antoni Chan synovialjoints ( View Tweet)
Functional MRI eval neuro-connectivity in 78 SLE pts
Cognitive impairment occurred in 48%; pts had:
👉longer disease duration
👉likely +LAC
👉abnormal fMRI
👉>blood brain barrier permeability
#ACR21 #Plenary Abstr# 0456 @rheumnow https://t.co/WI5CD73rvM
TheDaoIndex KDAO2011 ( View Tweet)
How about lipoprotein a as a potential biomarker for poor renal outcomes in #lupus?
Results of this study by Dr @CaoilfhionnMD and her group show that ⬆Lp(a) is strongly associated w/ proteinuria, ⬇ eGFR and ⬆PGA.
Interesting🤓
@RheumNow #ACR21 abs0327 https://t.co/MLgJ1tPJMp
sheila RHEUMarampa ( View Tweet)
#ACR21 Abst#0155
⭐︎ Tenosynovitis on MRI hand/foot in ACPA(-) undifferentiated oligo-arthritis pts is predictive of RA
➡️NPV 93%, Se 85%
⭐︎ BM edema not prognostic of RA development
Do you already use MRI to help detect early RA?
@Rheumnow
https://t.co/mpageAYeT2
Meral K. El Ramahi, MD MeralElRamahiMD ( View Tweet)
#ACR21
Many faces of cell death
Netosis in APS and #SLE
NETs and APS
🕸️NETs are prothrombotic🕸️ https://t.co/FG3VNbQPzh
Dr. Laura Lewandowski LauraLewMad11 ( View Tweet)
Pts with hospitalization from #SLE often do NOT have a f/u visit within next 2 weeks. 2/3 NO timely fu esp poor, young non-White& do worse. Is it due to fact that no one gets discharge summary or admission note or discrimination or health system prob #abst0464 #ACR21 @RheumNow
Janet Pope Janetbirdope ( View Tweet)
Targeting the HUGE dilemma!🎯
#Psoriatic vs Erosive #OA
PsA
👉 Fluffy bone formation(enthesitis of phalanges)
👉 Marginal erosions(vs central)
👉 Many jts in same digit(ray inv)
👉 Periarticular SOFT tissue swelling (dactylitis).
👉 NOT much hand OA
#ACR21 RadiologyBootCamp https://t.co/OQLPoeRLny
Ashima Makol MD AshimaMakol ( View Tweet)
Abstract 0444- Dr. Gupta
⭐️COVAD Study - ❗️18000 global pt survey looking at AE after COVID vaccination in Autoimmune disease
1227 IIM pt total- more injection site pain, headache, rash, fatigue in DM
#ACR21 #ACRAmbassador https://t.co/s4Fc5c9Kln
Veena Katikineni VeenaRheumMD ( View Tweet)
Blood Brain Barrier leakage correlates w/ CNS dysfunction in SLE - study by John Hanley of 78 SLE pts. CNS impaired in 48% SLE (more likely LAC+, APL+) correlated w BBB (10-30%) leaks. #ACR21, Abstr# 0456 https://t.co/DyUB2TU4pS https://t.co/Sd1tr0BF2H
Links:
Dr. John Cush RheumNow ( View Tweet)
Also DESIR cohort: male gender & higher education independently assoc'd w/ lower hazard of Sick Leave (SL.) Older age & higher disease activity assoc'd w/ more SL. AxSpA dz activity & SES play roles in SL predictions. Abs 0380 #ACR21 #RheumNow @RheumNow https://t.co/1lRhDAu7Ug https://t.co/RRG6BeUqvs
Dr. Rachel Tate uptoTate ( View Tweet)
ARRIA Study: Abatacept vs PBO in pre-clincial RA (N98) pts x 6 mos. Showed ABA prevented arthritis (8 vs 35%), improved MRI inflamm (61 v 31%), fewer D/C (14 vs 43%) - all signif. Further FUV 12 mos off therapy still significant at 18mos #ACR21 Abstract 0455 https://t.co/ZxFUj6KfLT
Dr. John Cush RheumNow ( View Tweet)
Pearls on Rheum imaging:
👉CPPD is not erosive
👉SC joint in OA is common (hard to image)
👉AC joint is 1st place OA affects shoulders (not GH)
👉Neuropathic OA progress rapidly, look at the TMTs
👉Get more views if you aren't seeing what you need
#ACR21 Radiology Bootcamp
TheDaoIndex KDAO2011 ( View Tweet)
Another one from Dallas! Congrats, Dr. Limanni! #ACR21 https://t.co/Rs3muuFQKh
TheDaoIndex KDAO2011 ( View Tweet)
Dr Oster presenting on IL-23 inhibitor Risankizumab in PsA. No surprises here, it works. We need comparative efficacy trials! Abstr#0453 #ACR21 @RheumNow https://t.co/mj8TeCqEcg
Richard Conway RichardPAConway ( View Tweet)
Plenary I
0454 LN mortality in the US & disparities using CDC WONDER data 1999-2019
"LN mortality exhibited profound disparities by race/ethnicity and place of residence"
https://t.co/UtMzaiL14D
#ACR21 https://t.co/C3fuq8anvR
Rheum Cat rheum_cat ( View Tweet)
#ClinicalPearl What lasts longer/⬆️retention in sero+ RA: Abatacept or TNFi or JAKi? #ACR21 abst#0463 @RheumNow Adjusting for confounding incl line of Rx / past bio Rx, #abatacept wins. But data not stratified for bio naive or exposed. Not sure if that would alter results https://t.co/1dEQncwPQF
Janet Pope Janetbirdope ( View Tweet)
The best overall winner for the #ACR21 image competition https://t.co/Kr9EVAYVip
Rheum Cat rheum_cat ( View Tweet)
#ACR21 #ACR2021 #ACRLive
wonderful slide set to explain the spinal phytes https://t.co/5SxN7GeDzh
EnvisionRheumat ERheumat ( View Tweet)