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@jhrheumatology Dr. Petri - if Lupus nephritis biopsy is very active start a dual therapy with MMF right away.
▶️ If not, continue to re-evaluate at 3 and 6 months for early combo therapy
#ACR21 Great Debate
@Rheumnow https://t.co/ctKdbWTMqy
Eric Dein ericdeinmd ( View Tweet)
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How can we tell whether a patient already on rituximab will have an immunogenic response to Pfizer COVID-19 vaccination?
Better chance of response if:
- RA or SLE, not AAV or IIM
- high serum IgG pre-last RTX
- longer time since last RTX
Israeli data #ACR21 ABST0437 @RheumNow https://t.co/yyuFd0eDH6
David Liew drdavidliew ( View Tweet)
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Dr McDermott @jeffsparks on risk factors for RA-bronchiectasis. Seropositivity, older age at RA onset, and lower BMI⬆️risk. Abstr#0288 #ACR21 @RheumNow https://t.co/7d2ZVWLzn6
Richard Conway RichardPAConway ( View Tweet)
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#ACR21 Great Debate: Voclosporin vs Tacro?
⭐️Voclosporin has carbon bond extension, changing how voclosporin binds to calcineurin.
⭐️Consistent dose-response prevents need for drug monitoring
⭐️Increases potency and results in improved metabolic profile
@Rheumnow https://t.co/cY93st7754
Eric Dein ericdeinmd ( View Tweet)
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This is an important slide showing how belimumab protected the GFR... ultimately the reason why we are treating #lupus nephritis patients - Prof Michelle Petri
@RheumNow #ACR21 #rheumatology
📌https://t.co/bO3ubqY2bf https://t.co/yuqwlKXDBH
Links:
sheila RHEUMarampa ( View Tweet)
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#ACR21 Abs#0101 on recombinant #zoster vaccine (RZV) in #IMIDs:
•High proportion of ≥50yos w/ IMIDs received RZV but 15–25% did not get 2nd dose within 6m
•#Vaccination higher in ≥65yos than 50–64yos
•Need better vaccine policy to encourage uptake in pts w/ IMIDs
@RheumNow https://t.co/i5JDJClTyQ
Mrinalini Dey DrMiniDey ( View Tweet)
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@jhrheumatology data on ESRD in Lupus Nephritis, Dr. Michelle Petri. #ACR21 Debate
▶️ 20% risk of renal failure in 20 years is way too high
▶️ C3 strongest predictor, dsDNA also seen
⭐️⬇️ complement, ⬆️dsDNA in lupus nephritis suggests Belimumab is good agent for LN
@Rheumnow https://t.co/ewLAxMgTT0
Eric Dein ericdeinmd ( View Tweet)
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#ACR21 @RheumNow
Abst#0359 by Garrido-Cumbrera et al. has mapped out the journey from symptom onset to diagnosis of axSpA across 13 European countries.
swethaann23 swethaann23 ( View Tweet)
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Before the Great Debate:
Next step for Lupus Nephritis?
#ACR21 @Rheumnow
Eric Dein ericdeinmd ( View Tweet)
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Abstract 0095 Barbhiaya et al examined risk factors for 'Long Haul' COVID-19 in Rheumatology Outpatients in NYC #ACR21 @RheumNow
Akhil Sood MD AkhilSoodMD ( View Tweet)
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Phase 2 German study demonstrates superiority of TCZ vs PBO in FMF. SAA levels only normalized in TCZ treated patients. Interesting concept that needs to be replicated in larger trials. Abs 0193 #ACR21 #RheumNow @RheumNow https://t.co/awqOpwg3gH https://t.co/lGzYglnkyM
Dr. Rachel Tate uptoTate ( View Tweet)
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Abst0242 #ACR21 @RheumNow FROST: 1st line Rx of SJIA 73 pts. two study arms: biologics & GC/MTX arm. In biologic arm 14% IL-1i switched to IL-6i, 0% from IL-6i to IL-1i. 50%GC/MTX eventually initiated biologic therapy . 57% of pts d/cGC use, and 75% had cJADAS-10 score ≤ 2.5 https://t.co/vH0AnocTr2
Olga Petryna DrPetryna ( View Tweet)
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Data science for the dumbs. Very informative talk from Dr Jamie Collins! Surely helpful for me. A good way to decide on the best supervised methods for data analysis in machine learning is to separate according to our goal: to explain or to predict? #ACR2021 @RheumNow https://t.co/J0j6VMkoTV
Aurelie Najm AurelieRheumo ( View Tweet)
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#ACR21 2nd abstract #0381 from #DESIR cohort by @ElenaNikiUK:
•High disease activity & decreased function assoc w/ greater #WorkDisability
•Not enough to just treat the disease! Need holistic approaches to improve function, QoL & work outcomes.
@RheumNow
https://t.co/jIs3Oj7nbJ
Mrinalini Dey DrMiniDey ( View Tweet)
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Completely new one for me, Dr Taniguchi presenting on using ear ultrasound to diagnose and monitor disease activity in relapsing polychondritis. Appears useful, I suspect in clinical practice more so for diagnosis. Abstr#0169 #ACR21 @RheumNow https://t.co/PLJtkYkP3A
Richard Conway RichardPAConway ( View Tweet)
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@jhrheumatology Dr. Petri at #ACR21 Great Debate.
Safety issues with Voclosporin:
1) Nephrotoxicity
2) Infection
3) CV Risk Factors
4) Malignancy
5) Neurologic toxicity
6) Osteoporosis
7) Drug interactions
8) Deaths
9) Pregnancy contraindication
@RheumNow https://t.co/wjluivmKNt
Eric Dein ericdeinmd ( View Tweet)
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#ClinicalPearl. Pts have no preference btwn phone or video telemedicine. You can get calls more easily in PJs, technology of internet may be difficult for elderly, hearing impaired & rural with poor internet bandwidth so I would’ve guessed phone was preferred @RheumNow #abst0112 https://t.co/1F4HH9nXB8
Janet Pope Janetbirdope ( View Tweet)
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RheumNow’s expanded coverage of #ACR21 is sponsored in part by @Novartis. All content chosen by RheumNow & its Faculty.
Dr. John Cush RheumNow ( View Tweet)
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Is holding MTX during breastfeeding overblown?
@MotherToBaby data showed that infants get 0.4% of mom’s dose 24 hrs post-MTX dose. Skip breastfeeding 1 day post-MTX may be safe. Consider monitoring infant CBC. Studies needed to follow infants longitudinally #ACR21 @rheumnow https://t.co/ikJvkk5BjI
TheDaoIndex KDAO2011 ( View Tweet)
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#ACR21 Abst#0170:
↑ epicardial adipose tissue volume predicts new coronary plaque development in the following RA patients:
⋆ <10 yrs dz (OR 5.75)
⋆ 1 cardiac risk (OR 3.4)
⋆ statin < 1 yr (OR 3.3)
⋆ w/o calcification at b/l (OR 2.65)
@Rheumnow
https://t.co/tnyWRVSger https://t.co/uhak4kdbll
Meral K. El Ramahi, MD MeralElRamahiMD ( View Tweet)