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Erosive Hand Osteoarthritis Portends Worse OA

d Jack Cush, MD

An erosive hand osteoarthritis (EOA) study from the Osteoarthritis Initiative shows that EOA is more common in older women and is strongly linked to further progressive, articular structural damage.

This was a longitudinal cohort study of 3,365 individuals without prevalent erosive hand OA at baseline.

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DAPSA PsA measure

Pathways to a Psoriatic Arthritis Diagnosis

d Jack Cush, MD

Ogdie and colleagues have retrospectively analyzed a longitudinal cohort of psoriatic arthritis (PsA) patients, showing that only two-thirds of PsA are diagnosed by rheumatologists, PCPs and dermatologists, with significant differences in what preemptive symptoms were noted by different subspecialties.

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RA,hand,elderly,active

Malnutrition and Quality of Life in Elderly RA Patients

d Jack Cush, MD

Rheumatoid arthritis (RA) imparts a significant disabilty and quality of life (QoL) limitations worsened by aging, but also by malnutrition.

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exhaustion,depression

Lupus Frailty Index Predicts Organ Damage

d MedPage Today

Patients with longstanding systemic lupus erythematosus (SLE) who were considered frail were more likely to accrue disease damage over time, a secondary analysis of data from a Chicago lupus cohort found.

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Hip fractures represent a major global public health problem - data from ASBMR meeting suggests this is from an aging population and suboptimal OP treatment. Global study shows incr # hip fractures per year, but Post-fracture Rx only at 11-50% https://t.co/LlMDTrH93E https://t.co/ucrPzcnLZh

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2125 RA pts in RCTS w/ baricitinib entered a long term F/U study. baricitinib pts had less XRay damage over 5 yrs; 5 yr No Xray progression was 60% on baricitinib 4 mg; 66% baricitinib 4 mg+MTX; vs 41% on just MTX monotherapy. https://t.co/pLuQCDSf6g https://t.co/wFs3G0DrJ7

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SLE hospitalized with ARDS from COVID-19 have significantly higher risks of death and poor outcomes (RR=1.7), compared 319 SLE vs 251,800 nonSLE - SLE was more impactful than other comorbidities in such poor outcomes https://t.co/8VJjdOmTbi https://t.co/jYTg6k1QNq

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We are at that time of year when rheumatology fellowship programs across the nation are exploring potential candidates to train. We share tips for both the interviewer and candidates on the blog today. https://t.co/eWQs9CwqSm https://t.co/iHeuQpsoQx

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Lessebo effect: 31 RCT comparing Biologic originator to a biosimilar or to PBO: Lessebo effx =better responses in Biosimilar vs PBO (ACR20=70%) than w/ originator vs PBO (ACR20=59%). ? due to PBO effx in active comparator, nocebo in PBO trials https://t.co/kvANomTHrb

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Beliefs translate to effects - ‘it will work’ (Placebo), ‘it will hurt’ (Nocebo); but now a "Lessebo" effect; neither benefit nor harm; instead a lower effect based on comparator. TNFi vs PBO has smaller effx (sup trial) than Biosimilar vs PBO (equiv) https://t.co/onyIkILqT9

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Drug Safety Risk Communication- The 800 lb Gorilla Approach https://t.co/6iSJjvlFF8 https://t.co/mPeJfWi1hY

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ASK CUSH ANYTHING! Rheums: Have a question for Dr. Cush? Record it here and we may feature it on an upcoming podcast. #RheumNow https://t.co/wzNmOzH4VE https://t.co/KzPzWpSoW1

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Metabolic syndrome (MetS) is associated with radiographic & nodal hand OA (HOA). 896 MetS positive & 1613 w/o MetS assessed w/ propensity matching. MetS had more xray HOA ((OR 1.32), PIPs (OR 1.52), DIPs (1.38), hand pain (1.25)https://t.co/aNEV5b6Tmv

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Malnutrition and Quality of Life in Elderly RA Patients https://t.co/4hEFTSaCga https://t.co/OPK3ThWqst

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Dr. John Cush RheumNow ( View Tweet)
Patients with longstanding systemic lupus erythematosus (SLE) who were considered frail were more likely to accrue disease damage over time, a secondary analysis of data from a Chicago lupus cohort found. Read more on #RheumNow https://t.co/jQt5mFrMtS https://t.co/HljgqdKZtH

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Dr. John Cush RheumNow ( View Tweet)
The AAOS has published their Clinical Practice Guideline for Management of Osteoarthritis of the Knee (Non-Arthroplasty); updating 19 of the 29 evidence-based recommendations and focuses on nonsurgical treatmentss to provide pain and patient function. https://t.co/faLi0X840d https://t.co/8iZkNEFkRy

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Study of 380 nonintubated severe COVID-19 pneumonia patients showed that those with the highest tertiles of FERRITIN (1322-13 ,418) showed significant reduction in mortality (HR, 0.16; 0.06-0.45) if given methylprednisolone [120-240] mg https://t.co/Jr1aWlPpOk

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Secukinumab (IL-17 inhibitors) can be safely used in HIV spondyloarthritis patients. https://t.co/hpCRJkR9w7

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EHR record study: prevalence of Psoriatic arthritis (#PsA) was increased w/ psoriasis severity. PsA prevalence=2.9 per 100 PY; Based on severity - Mild 2.1/100PY; Moderate 9.9/100PY & severe PSO: PsA risk was 17.6/100PY https://t.co/hXeA773KN4 https://t.co/AUIYZiSq5k

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Novel study of Pain Reprocessing Therapy;PRT in Chronic Back Pain. 151 pts w/ 10 yrs of LBP: 4 wk results - better w/ PRT (66%) (were pain-or nearly pain-free) vs PBO (20%) vs Usual care (10%), with gains maintained through 1-year follow-up https://t.co/lioI99GP80

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