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Running with Data (8.30.2024)
Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow.com - including tips on steroids, MAS, and myositis testing.
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Consumption of Alcohol and the Risk of Gout
Alcohol is a risk factor for gout and flares. While the inciting potential differs among alcohol types, are these differences sex specific?
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Diagnosing Seronegative Sjogren's Disease
Sjögren disease (SjD) is highly prevalent, but diagnosis may be challenged if anti-SSA antibodies or a labial salivary gland biopsy are negative. A recent cohort analysis suggests a novel autoantibody profile has predictive value SSA negative SjD and also in those with a positive labial biopsy.
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IV Methylprednisolone in Giant Cell Arteritis
A retrospective study in giant cell arteritis (GCA) patients suggests there is no added value using higher dose, intravenous methylprednisolone (IVMP) in early GCA.
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Antibiotics May Increase Inflammatory Arthritis Risk
A Danish registry study has shown that amongst those patients who develop inflammatory arthritis (IA), antibiotics use was more frequent when compared to the background population (BP).
IV Methylprednisolone in Giant Cell Arteritis
A retrospective study in giant cell arteritis (GCA) patients suggests there is no added value using higher dose, intravenous methylprednisolone (IVMP) in early GCA.
https://t.co/5udYabU5z5 https://t.co/5FHhBnAX2j
Dr. John Cush RheumNow ( View Tweet)
Pooled data from BE MOBILE 1 & 2 RCTs shows Bimekizumab (dual-IL-17A/F inhib) may protect against uveitis in axSpA pts. N=349 pts - 0.6% BKZ vs 4.6% placebo developed uveitis (1.8 vs 15.4/100 PYs); even in pts w/ Hx of uveitis (6.2 vs 70/100 PYs; p=0.004) https://t.co/f8Uk0rEg86 https://t.co/mY1ikcGCNP
Dr. John Cush RheumNow ( View Tweet)
Karolinska genotyping study of 329 JIA pts (oligo 161, Seroneg Poly 87, Seropos poly 12, Stills 24, ERA 22, PsA 19). HLA-DRB1*08 linked to JIA total; The HLA-DRB1*11 to Oligo; ANA+ JIA linked to HLA-DRB1-DQA1-DQB1, HLA-DRB1*11, & HLA-DPB1*02 https://t.co/1yNawNTEys https://t.co/dmmlH0CvRi
Dr. John Cush RheumNow ( View Tweet)
Antibiotics May Increase Inflammatory Arthritis Risk
A Danish registry study has shown that amongst those patients who develop inflammatory arthritis (IA), antibiotics use was more frequent when compared to the background population (BP)
https://t.co/5CEewNqirM https://t.co/FSOFp4N6ks
Dr. John Cush RheumNow ( View Tweet)
Anterior Cruciate Ligament Injuries are more commone in Female Athletes compared to males playing same contact sports. From 1990-2020, ACL injuries decreased in males by nearly 30%, but did not change in women, who are also less likely to return to sport https://t.co/EiyU440vRT https://t.co/QvYiSOVQZr
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Early axSpA defined by ASAS -- duration of symptoms ≤2 years; axial symptoms defined as cervical/thoracic/back/buttock pain or morning stiffness; regardless of Xray damage. ASAS community endorsed this proposal (88% in favour). https://t.co/JEviEgyIql https://t.co/jw11UsL6Iv
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Novel: 2 case reports of refractory macrophage activation syndrome successfully treated w/ an investigational monoclonal Ab (MAS825 ) to IL-1β, and IL-18 https://t.co/ZqC77njbjk https://t.co/13W8RZIiRZ
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Study of 425 RA pts & 36 mo. bDMARD retention rates w/ TNFi, IL-6i & ABA based on renal funct (eGFR: ≥60, 30–60, <30 mL/min) showing little effect of CKD w/ TNFi (45%, 28%, 34%), IL-6i (47%, 67%, 71%) & CTLA-4Ig (50%, 31%, 33%), maybe lower w/ TNFi & higher w/ IL6i… https://t.co/FhXoSnEfG1 https://t.co/N29nLBOoUj
Dr. John Cush RheumNow ( View Tweet)
New CDC guidance on Influenza vaccination!! All should recv, ideally in September or October. Immunocompromised (by meds or Dx) should recv Trivalent inactivated (IIV3s) & trivalent recombinant vaccine (RIV3), but not the live virus vaccine (LAIV3) https://t.co/r7euIb3BV9 https://t.co/Tx2pU2Onng
Dr. John Cush RheumNow ( View Tweet)
All in the Family (8.23.2024)
Dr. Jack Cush picks highlight reports from the past week on RheumNow, with reports on the challenge of lupus nephritis, perplexing skin issues, you don't know JAK (about Tyk) and the value of a good family history.
https://t.co/gwM77mJCnr https://t.co/HOGnymjhSZ
Dr. John Cush RheumNow ( View Tweet)
ANCA-associated vasculitis analysis of 6 European registries, 3868 pts (2434 GPA, 1434 MPA), age ~57 yrs. Identified 5 clusters: 3 w/ renal dz a) variable ANCA, Hi CRP & Cr; b) MPO+; c) PR3+ & 2 extrarenal 1) PR3+ multisystem; 2) ENT w/ low CRP. Clusters better predicted outcomes… https://t.co/20O58AAYAa https://t.co/KF6PTVfcRw
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Global Rheumatoid Arthritis Market estimated to be worth USD 22.77 billion in 2021 and is predicted to expand to USD 33.30 billion by 2030, with annual growth of 4.5% during the forecast period 2022-2030. https://t.co/J64mVxY4Ia https://t.co/6zg5g6KRdJ
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Dr. John Cush RheumNow ( View Tweet)
Cohort study shows GERD in 1539/1632 (94%) #SSc patients & 450/469 (96%) of SSc-ILD pts. GERD didnt influence ILD Dx or severity. But GERD Rx (PPI, H2RA) assoc w/ improved survival in those Scleroderma pts with ILD (p = 0.002) https://t.co/stQkpbmBCP https://t.co/e4BBz5c0av
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MDs: How long must you be on Pred 40 mg/d before you must slowly wean pred (vs stopping abruptly)?
Dr. John Cush RheumNow ( View Tweet)
New $$$ drugs are NOT usually steroid sparing, but a single center 716 RA pt study compared JAKi (n 156) vs bDMARDs (560) starts; JAKi assoc w/ more rapid GC reduction in1st 6 mos & 60% higher odds of GC D/C (adj OR 1.63) (>50% vs 40% @12 mos) https://t.co/shiDytQeBU https://t.co/dCjyw21uLd
Dr. John Cush RheumNow ( View Tweet)