Incomplete lupus? Undifferentiated connective tissue disease? Pre-clinical autoimmune disease? During the lupus pod at RheumNow Live 2024, Dr. David Karp discussed the spectrum of autoimmune disease and the confusing terminology that is used with the complex world of early autoimmune disease. He cautioned against the traditional use of phrases such as incomplete lupus or undifferentiated connective tissue disease, which are heterogeneous and poorly defined.
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Autoimmune disease and pregnancy
EurekAlert!
For many aspiring mothers with autoimmune disease, pregnancy can be daunting and full of unknowns. In some cases, those suffering from specific autoimmune conditions have chosen to forego pregnancy altogether due to concerns about their disease treatments and adverse pregnancy outcomes.
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Somewhere between 24 and 50 million Americans have an autoimmune disease, a condition in which the immune system attacks our own tissues. As many as 4 out of 5 of those people are women.
Dr. Petri reviews the 2023 ACR/APS Classification Criteria at #RWCS24 @RheumNow @RWCSmtg https://t.co/FWGsFk02Dn
85 Chinese SLE pts study of Dz activity & depression/ anxiety assessed by PHQ-9 & GAD-7. Good correlation betw SLEDAI-2K & SLE-DAS (r=0.76);also w/ mod-high activity (r=0.79), but less w/ mild Dz/remission (r=0.45). Anxiety/Depresion did not affect scores https://t.co/eyhgiYxf3P https://t.co/5LHg3HO21v
Full read overview of SJOGRENS SYNDROME, which can be Primary SS or Secondary (15% in SLE, 20% RA, & 30% systemic sclerosis). SS Organ involvement:
- CNS 2-17%
- Renal <=10%
- ILD 10-20%
-MSK 45-56%
https://t.co/RElOFfP2xr https://t.co/aJI041VCuE
Danish registries study shows maternal Autoimmune Dzs (all) were assoc w/ incr risk of childhood cancers (OR=1.25, 95% CI 1.06, 1.47), acute lymphoblastic leukemia (OR =1.52), Burkitt lymphoma (OR=2.6) & CNS tumors (OR=1.45); same seen for RA mothers https://t.co/HQO972ch9R https://t.co/dDEJUo8unq
Microbiome study of 16 SLE pts (44 fecal samples) shows that blooms of Ruminococcus gnavus pathobiont was assoc w/ lupus flares and may be the drivers of clinical of relapsing lupus disease https://t.co/Sj3dLesZpL https://t.co/7cu0X7jPM9
FDA Safety Warning: denosumab now has a Boxed Warning for risk of severe hypocalcemia in CKD pts taking Prolia (usually seen 2-10 wks post injx). Pts may or may not be symptomatic. CKD pts should have Ca and Creatinine monitored. https://t.co/UMYxjWz9n4 https://t.co/AG5wzBrY1Y
Nouf Al hemmadi
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The ultimate treatment goal in LN is long term preservation of kidney function.
Summary of part 3 of @andreafava brilliant talk.
#RNL2024
@RheumNow https://t.co/vwiAbWEmRh
Nouf Al hemmadi
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Very insightful talk on Vasculitis and pregnancy by Catherine Sims.
Pregnancy compatible medications.
Remission state.
Checking antibodies ; risk of transmission, pregnancy and fetal morbidity.
#RNL2024
@RheumNow https://t.co/81NAN1ulO5
Nouf Al hemmadi
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Urine biomarkers ( IL-16, CD163,CD206), parallel internal activity in lupus nephritis and and its decline at 3 months , best predict 1 year response .
Future is great for lupus nephritis , cant wait to start using them.
Great work @andreafava
#RNL2024
@RheumNow https://t.co/VIFMytHFyD
Nouf Al hemmadi
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Urine proteomics in lupus nephritis.
Summary of part one of his amazing talk.
@andreafava
#RNL2024
@RheumNow https://t.co/h8Eda0ZWVE
Nouf Al hemmadi
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Neutrophil signature in proliferative lupus nephritis.
@andreafava
#RNL2024
@RheumNow https://t.co/tNFIhohSvP
Nouf Al hemmadi
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2nd kidney biopsy in lupus nephritis have value. @andreafava
#RNL2024
@RheumNow https://t.co/47J1CGQL81
Nouf Al hemmadi
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Proteinuria doesn’t correlate with internal activity in lupus nephritis , we really need better biomarkers.
@andreafava
#RNL2024
@RheumNow https://t.co/bFuxVnUCEB
Dr. Gabalawy: "How do you know what disease patients will develop in this preclinical autoimmunity state?"
@drdavidkarp "it's like when weeds pop up in a garden, it's random ...if ACPA Ab pops up, you might have RA, if it's dsDNA, maybe lupus." #RNL2024 @RheumNow https://t.co/JmDtaTt3sU
Great talk -this is a summary slide on lupus nephritis and biomarkers to predict renal survival. When you get a chance, you have to watch @andreafava on #RNL2024 https://t.co/3PgFWCU9n6 @RheumNow https://t.co/AZNq9XrTMx
Low urine IL-16 at 12 months predicted kidney survival much better than proteinuria. Check out AUCs in the this first slide. Dr. @andreafava reviews this potential biomarker. Question if this could also be a possible target for treatment as well?
#RNL2024 @RheumNow https://t.co/cCLRERVXmq
Low urinary IL16 levels at 12 months predicts kidney suvial at 3 years better than proteinuria - @Andreafava @rheumnow #RNL2024 https://t.co/AEaL8n2nv8


