Dot the "i", Cross the "t" (10.11.2024) Save

Dr. Jack Cush reviews the news and journal articles from the past week on RheumNow.com. Today’s reports suggest where to look for help, especially with regard to pain.

1. Leiden Early Arthritis Clinic study (2011-17) of 431 pts found when RA is Dx in <12 wks, treatment costs were lower in Seropositive & negative RA. If Dx after 12wks, costs 316% higher in seronegative and 19% higher is autoantibody-positive RA pts https://buff.ly/4gUjFgF
2. A CATCH study of 2052 early RA (ERA) pts found high incidence of hypertension (26%) with the highest risk in older patients with traditional cardiovascular risk factors. Those without HTN, at enrolment, 24% developed HTN after median follow-up of 5 years. https://buff.ly/4eX0uko
3. LAMP study -Mindfulness in Managing Chronic Pain JAMA reports that outpatient resource mindfulness-based interventions (MBIs) delivered via telehealth are effective in managing chronic pain amongst veterans. https://t.co/ytSb03h0Fd
4. University cohort study of 673 adults w/ CLE or dermatomyositis finds that 32% take herbal supplements, esp in younger & Hispanic pts. 31% of DM experienced Dz onset or flare after supplements (vs 10% in CLE). Elderberry had highest risk of exacerbation https://buff.ly/4gZRkFC
5. Cancer risk increased following, but not before, a systemic sclerosis diagnosis. From a dataset of 10.1 million individuals, 1588 Dx w/ SSc & 206 developed cancer. Most common mucocutaneous (4.5%), lung (2%) breast (2%). Cancer risk higher after the Dx of SSc (HR ~1.4)… https://t.co/9GNMOU28TQ
6. Intracellular vs extracellular Calcium Pyrophosphate Crystals in 134 pts - 108 w/ intracellular & 26 w/ extracellular CPP crystals. Having Acute/chronic CPP crystal arthritis - 97% had intracellular and 62 extracellular crystals (p<0.001). Arthritis more likely to be asso w/… https://t.co/LY32oLJQv3
7. Upadacitinib safety across in RA, PsA, AS, atopic dermatitis >15000 Pt-Yrs exposure. Rates (per 100PYs) of Hzoster (1.6–3.6), NMSC (0–0.8) & incr CPK (4.4–7.9) higher w/ UPA vs comparators (RA, PsA); Deaths (0–0.8), SIE (0–3.9), MACE (0–0.4), VTE (<0.1–0.4), CA, malignancies (0.3–1.4) lowest in AS and AD… https://t.co/mx5ykTUttV
8. Korean Claims analysis of 413 radiographic axial spondyloarthritis (TNFi exposed=75 ). Recurrent CV events = 32 per 1,000 person-years; but lower if TNFi Rx'd = 19/1000PYs. TNFi exposure significantly lowered risk of recurrent CV events https://t.co/f69SHpXZCx
9. Genomic profiling of 34 ANCA-assoc vasculitis pts w/ glomerulonephritis suggests activity by cytokine-producing CD4+ & CD8+ T cells & potential for ustekinumab. 4 relapsing GN pts Rx w/ UST & CTX +steroids, w/ good responses, improved GFR and BVAS scores… https://t.co/ospA8CJ6JE
10. Artificial Intelligence in Diagnosing Sacroiliac Inflammation in axSpA 
11. Analgesic Prescribing in Patients with Inflammatory Arthritis 
12. Screening to Prevent Multimorbidity in Rheumatic Patients 
13. RheumNow.Live Feb 8, 9, 2025 in Dallas TX