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EULAR 2023 Notes from Milan (6.09.2023)
Dr. Jack Cush reviews highlight abstracts and sessions - covering lupus, RA, gout, Still's disease, safety data, AI in medicine and more - from last week's EULAR 2023 Congress held in Milan, Italy.
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A step change towards self-empowerment for people living with SLE
In my focus group consisting of people living with SLE and their carers, one of the keys issues raised by them was pertaining to poor reliable information about their condition. At the 2023 EULAR Congress in Milan, I learned about the wide scale dissemination and international launch of Lupus100.org project.
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Novel drug in development, LY3361237, is a BTLA (B & T lymphocyte attenuator) agonistic antibody to treat autoimmune Dz (eg SLE) - augments immune responses by activating checkpoint inhibitory receptors (CIRs). https://t.co/3iYq9UwHww https://t.co/RwrhqRO8cm https://t.co/tl8qVIXqjc
Dr. John Cush RheumNow ( View Tweet)
RheumNow Eular2023 Coverage - SLE Panel Discussion https://t.co/pLWOqZo2aw https://t.co/itAOjgmMTl
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Dr. John Cush RheumNow ( View Tweet)
A step change towards self-empowerment for people living with SLE
As I reflect on my research journey, I recall several issues that still need to be addressed in the management of SLE.
https://t.co/ElunbUgSGF https://t.co/YmA1YWPxVP
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Dr. John Cush RheumNow ( View Tweet)
SLE Trial: Dual BTK JAK Blockade compared Upadacitinib Monotherapy
Dr. Yuz Yusof discusses abstract OP0139 presented at EULAR 2023 in Milan, Italy.
https://t.co/os1tyiDnuT https://t.co/G0owdGek7f
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Dr. John Cush RheumNow ( View Tweet)
Efficacy and Safety of Baricitinib in Lupus Nephritis
Dr. Yuz Yusof discusses abstract OP0053 presented at EULAR 2023 in Milan, Italy.
https://t.co/ebQ5RwG2po
@Yuz6Yusof https://t.co/mUp7OXVK9K
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Dr. John Cush RheumNow ( View Tweet)
#Top #EULAR learnings #SLE #recommendations 1 Limit #prednisone 2 use #biologics early if poor prognosis 3 #lupus #nephritis - treat early with #belimumab or #voclosporin and more Rx in #RCTs #gamechanger https://t.co/JHQHu91tud
Janet Pope Janetbirdope ( View Tweet)
Promising new therapies in SLE
Dr. Yuz Yusof ( @Yuz6Yusof ) weighs in.
The pharmacology treatment in SLE is a rapidly expanding field of research that provides excitement and optimism to both the patients and the clinicians.
https://t.co/cdVw771HDs https://t.co/OYcN8hFLcP
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Dr. John Cush RheumNow ( View Tweet)
Unmasking Lupus Pregnancy: Adherence and Drug Monitoring Dilemmas
Preliminary data from a lupus pregnancy LEGACY cohort presented at #EULAR23 are alarming.
Dr. Bella Mehta ( @bella_mehta ) shares more.
https://t.co/cY2G4s4yR0 https://t.co/isepEb8OXD
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Dr. John Cush RheumNow ( View Tweet)
The future of lupus treatment is oral therapies?
There has been an explosion of trials in SLE, including nonrenal and glomerulonephritis studies.
@Janetbirdope
https://t.co/IQ9bxbTSV4 https://t.co/jVYOphxpAE
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Dr. John Cush RheumNow ( View Tweet)
Wasn’t following the SLE stuff #EULAR2023 but heard a lot of talk about both telitacicept & CAR-T, including meeting highlights by Christian Dejaco.
Both look pretty exciting - the longer the sustained remission with CAR-T, the more it looks like maybe the real deal @RheumNow https://t.co/oKzb8ojTcz
David Liew drdavidliew ( View Tweet)
#EULAR2023 #POS1156 Previous case series reported ~9% de novo nephritis in #SLE pts treated with belimumab for non-renal lupus. Post-hoc analysis of 5 BEL Non-LN RCTs showed 8% had de novo LN. Risk increased in Asians but lowered with low dose BEL or s/c form @RheumNow https://t.co/GqAr3tppWh
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
New 2023 @eular_org SLE recommendations
Key changes, in response to evidence:
- more caution re: steroids
- biologics earlier
- combo therapy (BEL or CNI/VCS) considered for lupus nephritis
#EULAR2023 @RheumNow https://t.co/J3Lp8owRyT
David Liew drdavidliew ( View Tweet)
Key points from #EULAR2023 on how to manage SLE
@RheumNow https://t.co/vJy7Cg7w8N
David Liew drdavidliew ( View Tweet)
#ClinicalPearl This is cool - think of SGLT2 for #lupus #nephritis? presented at #SLE recommendations @RheumNow #EULAR2023 @eular_org https://t.co/8mbNt2n64v
Janet Pope Janetbirdope ( View Tweet)
#SLE #EULAR recommendations What is new - use LESS #glucocorticoids, aim for none or 5 mg/d or less, use #biologics early if needed to prevent damage, #lupus #nephritis consider less pulse dose if using, voclosporin vs Belimumab ? it depends @RheumNow #EULAR2023 https://t.co/Ylnnl3pHOK
Janet Pope Janetbirdope ( View Tweet)
Diagnostic delay in #lupus is really prevalent!
#EULAR2023 @RheumNow
20% with new lupus diagnosis are hospitalized!
20% diagnosis is delayed for more than 3 months! https://t.co/1vCcezBrQS
Bella Mehta bella_mehta ( View Tweet)
Meds in #lupus at #EULAR2023 recs
- HCQ first line therapy. Target dose remains the same. Some discussion on monitoring levels if possible
- MAIN CHANGE - Glucocorticoids to be minimized (only use for bridging). Nephrologists more so in favor of steroid free remission @RheumNow https://t.co/d8WnUOgrwq
Bella Mehta bella_mehta ( View Tweet)
CAR-T cells in refarctory SLE- long term data presented #EULAR2023
Pts did well except some mild cytopenias. Pts remained in remission.
Maybe a good option in the near future for refractory pts!
@RheumNow https://t.co/NWoFBipOiQ
Bella Mehta bella_mehta ( View Tweet)
