The trouble with rheumatology may be the words we live by. Welcome to the eulogy for rheumatology 'dead words'. We're here today to celebrate the loss of rheumatology past. These are dead words in rheumatology, words fortified unfortunately by history and habit. The lexicon of rheumatology is unique, it's challenging and it's mostly incomprehensible to those who don't know...but those are the cornerstones of the greatest of medical subspecialties.
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SLE: A Mutated Gene and TLR7 Overexpression
EurekAlert!
A group of researchers lead by Min Ae Lee-Kirsch from the Department of Pediatrics, Medical Faculty, TUD Dresden University of Technology (Germany), studied four patients from two families who developed symptoms of SLE in the first years of life.
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Dr. Jack Cush reviews highlights, advances and hot topics in rheumatology from 2023 and the RheumNow website.
2023 was a year of growth and new horizons while returning to operational and practice standards (in care and education) established before the pandemic.
T cells are important in SLE flares (but are not the only player) - Dr. M Kahlenberg @rheumnow #RNL2024 https://t.co/xFeYrKHnGi
Richard Conway
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Treatment of SLE. EULAR guidelines via @Kahlenberglab @RheumNow #RNL2024 https://t.co/a5lWfRLuh3
Richard Conway
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Triggers for SLE flare by @Kahlenberglab . Here in Ireland, it is so often UV light (oh its not warm enough for sunblock, its cloudy, I was only out for 20 minutes, etc). We must get our messaging better @RheumNow #RNL2024 https://t.co/0T1oJH8MqJ
Richard Conway
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Mimics of SLE flare by @Kahlenberglab . They are many, common, and crucial @RheumNow #RNL2024 https://t.co/P7b72T9GS6
Type 1 IFNs are a unique feature that impacts disease – Dr. M Kahlenberg noted innate immune cells & tissue are triggered by UV light, microorganisms, causing changes to the immune system: DC’s and B cells are more active, represses Tregs, drive skin disease. #RNL2024 @rheumnow https://t.co/fXnPIFN6VA
“Flares require a trigger!” – Dr. M Kahlenberg on #SLE flares #RNL2024 @rheumnow https://t.co/rqAnAOfJZP
Is it a lupus flare or a mimic? Fibromyalgia, stress, infection, poor sleep, hypothyroidism, vitamin deficiencies can contribute to pain and fatigue in a patient. – Dr. M Kahlenberg #RNL2024 @rheumnow https://t.co/pLuqyy8gHm
Lupus has many flavors. If we are better able to sort them, we might be more better at finding effective treatments. @rheumnow #RNL2024 @DrDavidKarp https://t.co/rklqnA8Ur6
"SLE affects women in the prime of their life, 25% of pts go to the ER, up to 50% will have lupus nephritis; it is a deadly and costly disease.” - @DrDavidKarp on why we would be focusing on identifying preclinical SLE and preventing the disease #RNL2024 @rheumnow https://t.co/SIZ5ZBwu94
Should we define preclinical SLE as stages rather than using confusing nomenclatures like UCTD, incomplete lupus, etc? - @DrDavidKarp @rheumnow #RNL2024 https://t.co/OjRjdBzJWE
What early biomarkers are specific for SLE? How many will progress to stage 2? Who should we screen? Will patients revert to pre-stage 1? Is progression preventable? @DrDavidKarp on relevant questions we need to ask regarding preclinical stage 1 lupus. #RNL2024 @rheumnow https://t.co/bJPG68WdyE
Can HCQ prevent SLE? Results of the MONA-LISA study is being analyzed (pts have +ANA and 1-2 SLICC criteria for SLE randomized to PCB or HCQ) - @DrDavidKarp @rheumnow #RNL2024 https://t.co/9yoFXS7wMe
Eric Dein
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#RNL2024 @RheumNow
@DrDavidKarp
Incomplete lupus is heterogeneous term
"Stage 2" pre-classification stage as ILE/UCTD
Stage 1: non-specific antibodies, dysregulation
2: incomplete features
3: classified, multi-system disease
4: irreversible tissue damage https://t.co/CuLUzSZ24E
Face and neck vitiligo also responds to topical ruxolitinib. Dr. Strober #RNL2024 @RheumNow https://t.co/6N6A3Yq7RE
Microbiome study of 16 SLE pts (44 fecal samples) shows that blooms of Ruminococcus gnavus pathobiont was assoc w/ lupus flares and may be the drivers of clinical of relapsing lupus disease https://t.co/OXA4L6kG4p https://t.co/zXX7ZfWik1
SLE: A Mutated Gene and TLR7 Overexpression
A group of researchers studied four patients from two families who developed symptoms of SLE in the first years of life.
https://t.co/ggr1nMQnh0 https://t.co/c6IoJlgida
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