Linger on the Fingers (9.6.2024)

Jack Cush, MD

Sep 06, 2024 7:00 am

Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow.com. This week with a focus on fingers and better prescriptive follow through.

Is it possible that Helicobacter pylori (Gm neg) can exacerbate or cause RA? Infx of gastric epithelial cell line w/ H. pylori upregulated the expression of PAD4 and increased PAD4 activity, leading to Helicobacter pylori-induced citrullination? https://buff.ly/3z5Hkto
Study of 4821 pts (age 52 yrs) undergoing EGD - H. pylori infx seen in 2262, w/ long-lasting H Pylori (LLHp) infx in 1043 (21.6%). 6.3% dx w/ aCVD & 4.3% w/ RA. LLHp infection incr risk of aCVS (HR 1.57) & RA (HR 2.63) In RA, LLHp up risk for aCVD (7.89) https://buff.ly/3z5Hz7M
Immunomodulatory Prevention of Uveitis Relapse in Behçet's The results of a randomized, open-label, head-to-head trial shows that adalimumab was superior to ciclosporin in preventing uveitis relapses in patients with severe Behçet's disease. https://t.co/12fpuIZFmA
Study of 4370 RA pts (26534 PYs) saw 362 MACE (CV) events. RA activity & inflammatory markers assoc w/ MACE risk in bDMARD non-users (not those on bDMARDs). 515 bDMARD vs 3855 non-users (n=3855). Each DAS28-CRP unit incr MACE risk (HR 1.21) https://t.co/lRaHxTHzqe
Claims analysis, shows <0.5% of IBD or RA pts developed an invasive fungal infx within 1 year of TNF therapy initiation (. Histoplasmosis was the most common IBD = 3.3 IFI/100PY RA = 2.8 IFF/100PY https://t.co/ER9YCxecJT
Dactylitis is seen in 50% of PsA patients. Dactylitis is frequently associated with more severe PsA phenotype, often representing the initial feature of the disease. Many agents are effective but no b/tsDMARD is distinguished as being superior in dactylitis.… https://t.co/HLN8FGYSW8
“Vanishing Fingers" Acro-osteolysis in a patient with Scleroderma and renal failure and bilateral hand pain. Causes of AO include Scleroderma, PsA, hypertrophic osteoarthropathy, skeletal dysplasias, frostbite, Hyperparathyroidism, genetic disorders https://t.co/b2Ap4kny9b
While Raynaud's phenomenon severity is worst at very cold temperatures, it may also worsen during very warm temperatures, presumably due to air conditioning. Based on q3mos assessments of 2243 RP pts (88% female, 82% White, mean 55 yrs https://t.co/0EWxBJhdbS
Scleroderma skin findings in pts w/ skin of colour (SOC) - Raynauds was common but SOC pts had fewer hallmark Sxs: telangiectasias, calcinosis, digital swelling (complicating Dx). SOC had more severe pulmonary Dz & increased mortality, Atypical skin findings https://t.co/8XkelxqvYE
Retrospective observational study of 96 stable #SLE pts compared maintenance on HCQ vs belimumab. There were no significant differences in Flare rate (18% HCQ vs 8.3% BLM; p=0.47), damage index increase, SLEDAI, Pred dose or adverse events https://t.co/sVPMugSHn3
Sustained Hydroxychloroquine and Cardiovascular Outcomes https://rheumnow.com/news/sustained-hydroxychloroquine-and-cardiovascular-outcomes
Prospective Nurses' Health Study (n 204,175) included 212 w/ incident SLE; ultraprocessed food intake was assoc w/ >50% increased SLE risk & doubled risk for anti-dsDNA Abs. Sugar-/artificially sweetened drinks assoc w/ lupus risk (HR 1.45) https://t.co/jesfsgNvUY
CAR-T Like Effects with Bispecific Teclistamab https://rheumnow.com/news/car-t-effects-bispecific-teclistamab (Tecvayli), is a bispecific agent that targets both the CD3 protein and the B-cell maturation antigen (23 yo refract SLE in Berlin
Does Rheumatoid Factor Influence Anti-TNF Responses in RA? https://rheumnow.com/news/does-rheumatoid-factor-influence-anti-tnf-responses-ra
Register for the Advances in Rheumatology and Technology Symposium, taking place THIS WEEK!! 9/6 to 9/8 in Chicago! Conference Chairs Drs. Orrin Troum and Alvin Wells @alvinwellsmd bring together a dynamic mix of rheum topics. https://t.co/Qx1lOf5qxD