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Is a Biomarker for Adverse Pregnancy Outcomes on the Horizon?
With a better understanding of pathophysiology, improved management guidelines, available medications, and a multidisciplinary approach, pregnancy for lupus patients has become more feasible. Despite these improvements, some patients still experience poor outcomes, highlighting the need for biomarkers that can predict these risks. An abstract presented at #EULAR2024 (POS1393) explored this possibility.
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Might Synovial Biopsy Predict Rheumatoid Treatment Responses?
EurekAlert!
Multi-modal analysis of rheumatoid arthritis (RA) synovitis pathotypes enables more accurate choices of first line cDMARDs treatment, suggesting a predictive value to synovial biopsy.
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Matters of the heart: cardiovascular disease and mortality in RA
Two large retrospective cohort studies presented by the team at Mayo Clinic, Rochester MN examine the burden of stroke, as well as overall and cause-specific mortality in people with RA (POS0591 and POS0592).
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POS1035 FVC & risk of lung transplant & mortality in #RAILD
50% pts had FVC % predicted decline in ~6.5yrs
2/3 identified groups more strongly assoc w transplant or ILD-related death than INBUILD definition ➡️marked heterogeneity in ILD progression
#EULAR2024 @RheumNow
Mrinalini Dey DrMiniDey ( View Tweet)
📄 You can now read my article on #CardiovascularDisease, #Stroke & #Mortality @RheumNow!
🌟 Featuring 2 cohort studies from @MayoClinic, presented at #EULAR2024
🔗 https://t.co/b639vE5hSA
@MyasoedovaElena
Mrinalini Dey DrMiniDey ( View Tweet)
#EULAR2024 OP0193 Watch out, blinatumomab will BiTE! Bi-specific T-cell engagers (BiTEs), kill Bcells by engaging Tcells. In 6 refractory #RA patients (failed 3 x ts/bDMARDs), deep blood & tissue depletion were met, good response. Brief raised temp but no cytokine storm @RheumNow https://t.co/OmxSbTXfZq
Links:
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
Fascinating - @ndb_org installed an app to measure smartphone usage, and texting less and moving less were associated with more flares.
The pseudo-wearable in our pockets??
#EULAR2024 POS0678 @RheumNow https://t.co/ZA0hd3Q10d
David Liew drdavidliew ( View Tweet)
Is muscle US useful in RA?
100+ pts 1yr followup
BL muscle thickness correlated w/ grip strength improvement
HAQ improv correlated w/ pennation angle vastus lateralis
No diff between muscle morphology & DAS
I'd say it's still easier to US joints!
@RheumNow #EULAR2024 POS1033
Aurelie Najm AurelieRheumo ( View Tweet)
RA patients on abatacept have an appalling immunogenic response to Shingrix. Humoral fades away in the first year, and an absence of cellular responses.
Alarming and need strategies to combat this #EULAR2024 POS0620 Winthrop/@RADoctor @RheumNow https://t.co/8gY9ocLBDp
David Liew drdavidliew ( View Tweet)
#EULAR2024 POS0390 What impact of regulatory warning on JAK-i on access to therapy? Data from UK BSSR-BR reported 4 in 5 #RA patients would have been considered ‘high-risk’. Of these, 28% had failed ≥3 biologics; so no suitable alternatives. Enormously impacted @RheumNow https://t.co/XeS9qHXSpH
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
What psychosocial factors drive treatment outcomes and disease activity for people living with rheumatoid arthritis?
#EULAR2024 POS0309-PARE @DrMiniDey @ElenaNikiUK @RheumNow https://t.co/q0tTLSL044
David Liew drdavidliew ( View Tweet)
Do we give enough attention to pts mental health?
2 cohort 400+ RA tREACH & DEPAR 500+ PsA
RA 20% depression 30% anxiety
PsA 19% depression 22% anxiety
2 yrs no remission
RA OR 2.5 depression OR 1.7 anxiety
PsA OR 6.10 depression OR 4.67 anxiety
@RheumNow #EULAR2024 POS0946 https://t.co/ok4HRNJqgY
Aurelie Najm AurelieRheumo ( View Tweet)
#opportunistic inf in #autoimmune dz
🎤 @khyrich
👉#herpes zost is ⬆️⬆️,esp😳#lupus (💉 >18yo🇺🇸)
👉#HBV react ⬆️⬆️ w/ RTX (9.1%) >>TNFi, JAKi, IL-6
👉 🙅♂️ #TB repeat 🧪 on #DMARD if 🚫new risk fact/gap⚠️
🔗#eular 2022 guide:
https://t.co/PIpGpTrH28
#eular2024
#rheumx
@RheumNow https://t.co/kouXvradiC
Links:
- https://ard.bmj.com/content/annrheumdis/82/6/742.full.pdf
- https://twitter.com/AMinalyan/status/1801606024576565284/photo/1
- https://twitter.com/AMinalyan/status/1801606024576565284/photo/1
- https://twitter.com/AMinalyan/status/1801606024576565284/photo/1
- https://twitter.com/AMinalyan/status/1801606024576565284/photo/1
Artem Minalyan, MD, DABOM AMinalyan ( View Tweet)
How good are we at picking up depressing in RA patients?
In this Polish registry:
- 1.8% had a depression diagnosis
- 21% had low mood on HAQ
& depression has real correlates with disease activity.
Plenty to think about with truly holistic RA care!
#EULAR2024 POS1045 @RheumNow https://t.co/ZNbMVo8TGk
David Liew drdavidliew ( View Tweet)
Bold conclusion from Japan:
laughter improves function in RA.
I like it
Feel like it might be partially a correlation/causation link but if an hour of laughter can push down IL-6 levels in RA patients, time for reimbursement for stand up comedy?
#EULAR2024 POS1029 @RheumNow https://t.co/EpHnX50PgF
Links:
David Liew drdavidliew ( View Tweet)
Look out for multimorbidity in rheumatoid arthritis. McInnes I #EULAR2024 @RheumNow https://t.co/kgshkNcyLn
Dr. Antoni Chan synovialjoints ( View Tweet)
#EULAR2024 Please find our Day 1 & Day 2 Recap of selective abstracts/research presented at the conference 😃@RheumNow @DrMiniDey
https://t.co/AHl18gS7gF https://t.co/LEoa9rBNly
Links:
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
OP0162 looks at mortality in 21277 seropositive and seronegative #RA
5-year mortality risk in both groups decreased over time but is higher in seropositive vs negative
Sex-specific analysis reveals serological status in women did not affect mortality risk
@RheumNow #EULAR2024
Mrinalini Dey DrMiniDey ( View Tweet)
➡️OP0127- Can we predict who will get persistently active disease in people with palindromic rheumatism (PR)?
📊Cohort of 161 PR
❗️Predictive factors: Female gender, CCP, RF, >40yo, smoking & interval between flares of <1m ➡️ may be used to risk stratify
@RheumNow #EULAR2024
Mrinalini Dey DrMiniDey ( View Tweet)
Différent stages of RA with disease progression. McInnes M #EULAR2024 @RheumNow https://t.co/iKpggGYU0k
Dr. Antoni Chan synovialjoints ( View Tweet)
