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Can we predict pre-clinical RA-ILD?
@Juge_P_A ESPOIR cohort. model w/ 4 variables: male gender, older age @ diag, mean DAS-28 over follow-up and MUC5B variant ▶️ preclinical ILD after 13 years of RA w/ AUC=0.82 CI 95% (0.72-0.91) (Sens 80%, Spe 56%)
#POS0095 @Rheumnow #EULAR2021 https://t.co/bPyidNhNuO
Aurelie Najm AurelieRheumo ( View Tweet)
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Curious to find out the answer?https://t.co/cXjUeQAwHD
#EULAR2021 @RheumNow #OP0012 https://t.co/7q5yZLD96v
Links:
Aurelie Najm AurelieRheumo ( View Tweet)
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Very informative #EULAR2021 WIN session on MIS-C @EULAR_org
👉 Steroids early
👉 IVIg in all
👉 anticoagulant use remains variable
#Coronary aneurysms
✅ occur during acute phase in MIS-C and improve with treatment
✅ occur in the late/convalescent phase of #Kawasaki disease https://t.co/Ff3rX6u5VK
Ashima Makol MD AshimaMakol ( View Tweet)
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Does skin #lupus respond differently to rituximab?Dr Carter @LucyCarter6 reported 75% cutaneous response rate but overall non-response to tx was caused by skin domain. Interestingly, resistant skin post-tx was associated with low baseline #IFN scores #EULAR2021 #OP0134 @RheumNow https://t.co/JdtwdwNR4Z
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
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Can machine learning show JAKi effects for safety? Off target binding predicted in #tofacitinib 58, #baricitinib 41 but NO pathway for thrombosis or viral infection. Could have repurposing for + effects on lung vasculature & antifibrotic effects POS0091 #EULAR2021 @RheumNow
Janet Pope Janetbirdope ( View Tweet)
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MACE events with #JAKi is as clear as mud! You voted >50% NOT Sure 1/3 only some Jakis vs MACE in #TNFi! Dunno #EULAR2021 @RheumNow @eular_org https://t.co/vWUgKSwAap
Janet Pope Janetbirdope ( View Tweet)
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Does anti-CD20 mAb still have a place in #Sjogren? Dr Pontarini analysed salivary gland biopsy from TRACTISS and reported beneficial effects of RTX in⬇️regulating genes involved in immune cell recruitment, activation and organisation in ectopic GC #EULAR2021 #OP0136 @RheumNow https://t.co/FRUvo4JxTx
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
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Do you increase spacing of TNF-i administration in your patients with axSpA with sustained low disease activity for one year? OP0138 results showed similar relapse rates in those with increased spacing intervals and those on standard dosing regimen. #EULAR2021 @RheumNowNews
Meral K. El Ramahi, MD MeralElRamahiMD ( View Tweet)
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Does Guselkumab (IL23-i) modulate gene expression in #PsA? Dr Siebert analysed samples from DISCOVER RCTs & reported normalisation of⬆️regulated genes (e.g. Neutrophil,monocyte) and ⬇️regulated (B-,T- and NK cells) signatures by GUS post-therapy #EULAR2021 #POS0195 @RheumNow https://t.co/2qtpxrrwkF
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
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AVN in SLE is ⬇️ing over time! risks are same: younger, male, glucocorticoids & also found hyperlipidemia. ?due to older age of onset & less steroids over time & better immune suppressants POS0730 @RheumNow #EULAR2021 @eular_org https://t.co/IG3NVrZl4D
Janet Pope Janetbirdope ( View Tweet)
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Once approved, what type of patients with #SLE would you treat with #anifrolumab? #EULAR2021 #OP0131 @RheumNow
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
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Sjogren’s QoL reported dryness correlates with objective salivary flow
⭐️lower perceived dryness associated with higher immunologic activity
Abs#POS0102
#EULAR2021 @RheumNow
Robert B Chao, MD doctorRBC ( View Tweet)
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#EULAR2021 OP0138 - Radiographic AxSpA in LDA, SPACING anti-TNF vs continue care. 83% were able to ⬆️ dosing interval at month 12, drug efficacy recovered in pts with relapsed disease. Worth trying in stable patient who wants to wean down meds. @RheumNow
Eric Dein ejdein1 ( View Tweet)
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Do patients with #SpA have a different phenotype if they have "root joint disease"?
Find out at the #EULAR2021 Poster Tour #POS0239
or at https://t.co/30JdHxTKus https://t.co/ocEefm8II9
Nelly ZIADE 🍀 Nellziade ( View Tweet)
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@AurelieRheumo @RheumNow Looks like modern art and not a prediction model. Lots of scatter in data by my untrained eyes! @RheumNow #EULAR2021
Janet Pope Janetbirdope ( View Tweet)
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@MeralElRamahiMD @RheumNow True that axSpA is diff from pts with peripheral SpA predominantly but isn’t it circular reasoning to say axial has more HLAB27+ as that is group in whom criteria were developed including HLAB27?
Janet Pope Janetbirdope ( View Tweet)
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Poorer outcomes with #JAKi in pts who get #SARSCoV2 but ? related to line of therapy - worse off if 2nd line advanced Rx in RA vs 1st line? JAKi has short half life so it washes out? And..#baricitinib added to #remdesivir improves outcomes NEJM @RheumNow #EULAR2021 #OP0006 Dunno! https://t.co/583z6Mlw3y
Janet Pope Janetbirdope ( View Tweet)
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Do we need to monitor #ECG in patients on #HCQ and #polypharmacy? Dr Antivalle reported ⬆️QTc interval in HCQ vs controls. Only 3/132 was above ULN in HCQ group though. Importantly,⬆️QTc was noted more in HCQ + co-meds (e.g. PPI) #EULAR2021 #POS0090 @RheumNow https://t.co/1Ui4MghqIk
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
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Don’t forget to use imaging that you already have!
CT Abd/Pelvis (ordered for nonMSK) of 301 IBD pts shows underlying sacroilitis
⭐️60/301 had sacroilitis on CT
⭐️11/60 had AxSpA
⭐️3/60 previously undiagnosed axSpA
Abs#POS0035
#EULAR2021 @RheumNow
Robert B Chao, MD doctorRBC ( View Tweet)
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➡️ASTERA = PIII trial that showed superior efficacy of Netakimab (IL-17Ai) vs PBO in pts w/ active r-axSpA. Excluded pts prev tx w/ 2 or more TNFi
➡️OP0142 = sub-analysis showing Netak ⬇️ dz activity in AS pts irrespective of sacroillitis on MRI at b/l
#EULAR2021 @Rheumnow https://t.co/faT3M0xQiR
Meral K. El Ramahi, MD MeralElRamahiMD ( View Tweet)