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RheumNow Podcast – Myth Busters (5.21.2021)

d Jack Cush, MD

Dr Jack Cush reviews the news and journal reports from the past week on RheumNow.com

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Lower Rates of Serious Infection with Ustekinumab in Psoriatic Disease

d MedPage Today

Patients with psoriasis or psoriatic arthritis who were being treated with ustekinumab (Stelara) had lower rates of serious hospitalized infections than patients receiving other biologics or small molecule therapies, a study utilizing data from two commercial claims databases found.

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Tocilizumab Risk of Diverticulitis and GI Perforation

d Jack Cush, MD

A French registry analysis compared the risk of diverticulitis and gastrointestinal perforation (GIP) in rheumatoid arthritis (RA) patients treated with biologics and found a greater risk of both in patients receiving tocilizumab (TCZ) compared with those on rituximab (RTX) or abatacept (ABA

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TAA, TAR, Ankle, replacement

Total Ankle Arthroplasty vs. Arthodeisis?

d Jack Cush, MD

 The Journal of Bone & Joint Surgery reports the findings of a 4-year trial comparing outcomes of total ankle arthroplasty (TAA) versus ankle arthrodesis (AA) in patients with severe ankle arthritis; finding that while both groups improved, TAA was associated with less pain and better function after 4 years.

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One of our most popular stories-- CDC: Fully Vaccinated Can Shed Masks and Resume Travel https://t.co/K3LYL5w7F8 https://t.co/NlvZsjO2el

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#LupusAwarenessMonth Dr. Mike Putman - TULIP Trials - Anifrolumab in SLE https://t.co/cqZiulDMFm https://t.co/Vo17RfBOSk

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Cohort analysis of 251 SLE patients with and without new-onset arrhythmia (taken from 2499 incident SLE Taiwan claims data). Plaquenil use showed no increased risk of arrhythmia (adj OR = 1.49; 0.98-2.25) or ventricular arrhythmia (adjOR =1.02). https://t.co/vkTi3X7hiM

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Real world study of 21 GCA patients over age 80 yrs taking tocilizumab. (for GC-sparing in 14, relapsing Dz in 8, severity in 4, DMARD failure in 4). 8 [2–21] months post-TCZ, 67% were off GCs. AE included 4 Hi Chol, 3 SIE, 2 cytopenia, 1 hi LFTs https://t.co/ER0ROQw4ma

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Were you unable to attend the last Tuesday Night Rheumatology? Check out the Spondyloarthritis highlights with Drs. Haroon, Kavanaugh and Wang. https://t.co/S4y6TvKyWO https://t.co/yeR2rPxouc

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Another reason to be vaccinated: 2020-21, with mask wearing & distancing, influenza #s dropped by 98% to record lows In the USA; Flu test positives dropped from 19.34% to 0.33%. PLEASE NOTE; COVID VACCINATION IS WAY WAY MORE EFFECTIVE THAN MASK WEARING! https://t.co/vS72bvit7r

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RNL 2021: Pneumonia and RA - Dr. Jack Cush Did you miss #RNL2021? Our great panels are now available to watch on the site. https://t.co/1TR7fmdLq2

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There is no downside to promoting oral health in our patients. Even without RCTs, knowing that there are possible links between oral health and RA outcomes is enough reason to have discussions with our patients with periodontal disease, and encourage treatment #EULARJC

Jon T Giles JonTGiles1 ( View Tweet)

If any rheums out there have not watched the vaccine town hall by @ACRheum I highly recommend it. A master class on vaccine counseling by @gradydoctor ! Thank you! Thanks @IreneBlancoMD and @DrDavidKarp https://t.co/4ofQVkjKYz via @YouTube

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Jilaine Bolek Berquist BolekBerqui ( View Tweet)

Metanalysis (11 RCTs, 19 registries) of Pulm arterial HTN assoc. w/ CTD (w/ 1,267 & 4,008 CTD-PAH pts), showed Investigational Rxs reduced morbidity/mortality by 36%. CTD-PAH survival was lower (62 vs 72%) @3yrs, but improved after 2010 (73 vs 65%) https://t.co/0BkO70AQfi

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Textbooks say fever is common in lupus ("36%–86%") BUT IT IS NOT! Lupus is cause of FUO in 5%; Fever is seen in a minority of SLE onsets; Fever occurs w/ SLE complications - vasculitis, pneumonitis/serositis/alveolar hem, CNS, & INFECTION! https://t.co/KvZeo6Q1WY

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"Evidenced based medicine is not enough; you can perfectly execute the wrong decision." - Dr. Dino Kazi on the important role of clinical reasoning in patient care #UTSWRheumGrandRounds

UTSWRheum UTSWRheum ( View Tweet)

Great UTSW Rheum Grand Rounds by Dr. Dino Kazi on "Clinical Reasoning". Graphic shows stages of learning & Dunning Kruger effect describing gap of what we dont know but think we do know @UTSWRheum @UTSWIMchief @DinoKazi https://t.co/bFiWOJ2IXz
Dr. John Cush RheumNow ( View Tweet)
Checkpoint Inhibitor Safety in Melanoma Patients with AID A study from the DMT shows that the use of checkpoint inhibitors for advanced melanoma in AID patients didn't increase the risk of irAEs, except for those with preexisting IBD. https://t.co/VFzBOlc0wc https://t.co/0zfr8YFmZr

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Good review of the epidemiology of Psoriatic disease - Psoriatic arthritis (PsA) is a chronic, progressive musculoskeletal disease that affects 0.1%–1% of the general population and ~20% of patients with psoriasis. Might wt loss be a prevention? https://t.co/kvoNqMMr7r

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Rituximab Tops Mycophenolate Mofetil for Pemphigus Vulgaris. One year study of 135 moderate-to-severe pemphigus patients saw complete remission in 40% of RTX vs 10% of MMF patients. https://t.co/yAauFRjHCe

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