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Checkpoint Inhibitor Safety in Melanoma Patients with Autoimmune Disease

d Jack Cush, MD

Immune checkpoint inhibitors (ICI) are well known to cause immune-related adverse events (irAEs). A study from the Dutch Melanoma Treatment Registry shows that the use of checkpoint inhibitors for advanced melanoma in AID (autoimmune disease) patients did not increase the risk of irAEs, except for those with preexisting IBD.

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OA, erosive, inflammatory, DIP

Severity Associated with Erosive Hand Osteoarthritis

d Jack Cush, MD

Erosive hand osteoarthritis (EHOA) was studied as part of the Osteoarthritis Initiative, and shown to increase with advanced age and female sex, with developmental findings to suggest that EHOA as a disorder of skeletal frailty.

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Malar,rash,SLE, Lupus

Anifrolumab Reduces Lupus Flares

d Jack Cush, MD

Anifrolumab has been studied in two large phase 3 trials in systemic lupus erythematosus (SLE) patients; pooled data from both the TULIP-1 and TULIP-2 trials were used to show that anifrolumab reduces flares in patients with moderate to severe SLE. 

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Psoriasis, arms, PsA

IL-23 Inhibitor Tildrakizumab Effective in Psoriatic Arthritis

d Jack Cush, MD

Tildrakizumab, a monoclonal antibody targeting interleukin-23p19 studied in adults with psoriatic arthritis (PsA), was found to be superior to placebo and well tolerated without reports of uveitis, systemic fungal infections, inflammatory bowel disease, major cardiac events or death. 

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RNL 2021: Best of times, worst of times (Keynote): Dr. Iain McInnes Dr. Iain McInnes presents his keynote lecture, Best of Times, Worst of Times..., at RheumNow Live 2021. https://t.co/v3hOYuJZad

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Rheumatologists--submit a question or case for Jack Cush and we may use it on an upcoming podcast. https://t.co/wzNmOzH4VE https://t.co/pWbUcmLu2O

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Dr. Jack Cush - Hemoptysis in Lupus https://t.co/SjBazKiTW8 #LupusAwarenessMonth https://t.co/6z2R456Clm

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Did you miss #RNL2021? We'll be sharing them on the site. RNL 2021: Interstitial Lung Disease in RA - Dr. Jeff Sparks ( @jeffsparks ) https://t.co/0Z5PsWyMFH

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International survey by the World Lupus Federation of 6,100 lupus pts from over 85 countries shows 50% reporting decreased access to lupus healthcare; including /rheumatologist 36%, medical tests 29%, infusions 24%, meds 17% https://t.co/5tlbiP65gf

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Cohort study of 4.4 million adolescents w/ 7.6 million fluoroquinolone Rxs found a 90 day LOW risk of tendon ruptures (0.47/1000 Pt yrs) or tendinitis (9.34 per 1000 person-years). These events were rare in kids and appear to be more common in adults. https://t.co/52uGZKAptc

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DASH study: ?effect of diet on BP in 459 adults given 1) USA diet; 2) Fiber, fruits, Veggie (FFV) or 3) DASH diet. Compared to typical American diet, DASH diet (less so FFV) reduced mean SUA 0.25 mg/dl (P=.004); moreso w/ higher SUA levels https://t.co/XhCK9xp67P

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BSRBR: Demyelinating Disease Following Anti-TNFα Therapy Analysis of patients receiving TNFi therapy in the BSRBR shows that the risk of demyelination is rare but is marginally increased by taking TNFi therapy. https://t.co/oHJXOa96Kn https://t.co/m2GpeEQxnP

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RheumNow Live 2021 is now available for everyone! RNL 2021 was held March 20 - 21 in Fort Worth, TX, and now all can partake in the meeting - by video, podcast or by signing up for Tuesday Night Rheumatology (TNR). We hope to see you there! https://t.co/jaisVc2kGt https://t.co/vYHm8QGD14

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Genomic study of 1190 vasculitis pts & 11302 controls identfied a genetic variant, rs3743841, located in an intron of the NAGPA gene, reached genome-wide significance for Kawasaki (p= 8.06x10−10) and IgA vasculitis.(p= 1.25x10−7; OR 1.47 ) https://t.co/bUX5MdmOSM

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Today Sandoz announced that the US Supreme Court has denied Sandoz appeal for their Enbrel biosimilar (Erelzi; which is FDA approved) to be marketed in the US. This biosimilar is available out side of the US, but wont be US available till 2029. https://t.co/aABw1dpbMr

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"Arthritis Mutilans" - worse outcome to chronic inflammatory arthritis is due to 5 disorders: 1) RA 2) Psoriatic arthritis 3) Tophaceous gout 4) polyarticular JIA 5) Multicentric reticulohistiocytosis (Ive never seen this!!) https://t.co/XYmBEW1F0R https://t.co/tGWNG9Aklw

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Dr. Janet Pope - Comorbidities in SLE From ACR 2019 https://t.co/1BjfVOfL4i #LupusAwarenessMonth https://t.co/apjrwa36dA

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Increased Methotrexate Liver Disease in Psoriasis https://t.co/sEZajDIkSz

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RNL 2021 - Assessing Psoriasis: Melodie Young, MSN, ANP-c https://t.co/ZzOnJOtKjz

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Join us this Tuesday for Tuesday Night Rheumatology focusing on Spondyloarthritis with sessions from Dr. Nigil Haroon, Dr. Artie Kavanaugh, and Dr. Robert Wang. https://t.co/Jr6H0Yg6xs https://t.co/UXx37liLSZ

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