All News

LBP_0.jpg

Diagnostic Delay in Spondyloarthritis

d Jack Cush, MD

Literature review and metanalysis of many studies suggests that significant delay to diagnosis in axial spondyloarthritis (axSpA) exist, are longer than other rheumatic diseases and have not changed over time.

Read Article
liver.jpg

Increased Methotrexate Liver Disease in Psoriasis

d Jack Cush, MD

A Danish cohort study examined the risk of methotrexate related liver disease risk in patients with psoriasis (PsO)and psoriatic arthritis (PsA), and found that compared to rheumatoid arthritis (RA), psoriatic patients had up to a 3 fold higher risk of liver disease. 

Read Article
MS, multiple, sclerosis, demyelinating, brain, plaque

BSRBR: Demyelinating Disease Following Anti-TNFα Therapy

d Jack Cush, MD

Analysis of patients receiving anti–tumor necrosis factor α (TNFi) therapy in the British Society for Rheumatology Biologics Register (BSRBR) shows that the risk of demyelination is rare but is marginally increased by taking TNFi therapy. 

Read Article
lung%2Cbright.jpg

Increased Risk of COPD in ACPA+ Pre-RA Patients

d Jack Cush, MD

The lung and its pathology is uniquely tied to rheumatoid arthritis (RA) and its pathogenesis.  A new study shows that elevation of anti–citrullinated protein antibodies (ACPAs) before diagnosis of RA increases the risk of developing chronic obstructive pulmonary disease (COPD

Read Article
shingles2.jpg

New Side Effect From mRNA COVID Vaccines?

d MedPage Today

Herpes zoster reactivation -- a.k.a. shingles -- following COVID-19 vaccination in six patients with comorbid autoimmune/inflammatory diseases may be a new adverse event associated with the Pfizer/BioNTech mRNA vaccine, suggested a new report.

Read Article
Diary study of 79 FM, 86 RA, 33 w/ both FM/RA shows that compared to RA, pts with FM have worse daily well-being, negative affect, more isolation, inability to complete plan. FM had more perceived stigma and lower well-being. https://t.co/YZdhvYghuI

Links:

Dr. John Cush RheumNow ( View Tweet)

Sonelokimab is a novel trivalent nanobody aimed at IL-17A & IL-17F; tested at multiple doses vs Placebo or secukinumab in 383 plaque psoriasis pts: SON at doses 60-120 mg had efficacy similar to SEC; but SON had more Candida infx (17·4% vs 1.9% SEC) https://t.co/Nhh9UyX3i0

Links:

Dr. John Cush RheumNow ( View Tweet)

"Dr. M McMahon distinguishes SLE presentation in different ethnicities. -People of color have > risk for renal dz -Black patients have higher rates of SkM and neuro dz -Death 4X > in Asians, 6X > in Hispanics #RNL2021 " #RNL2021 coverage from @KDAO2011

Dr. John Cush RheumNow ( View Tweet)

News Feature: Increased Risk of COPD in ACPA+ Pre-RA Patients A new study shows that elevation of ACPAs before diagnosis of RA increases the risk of developing COPD and/or asthma. https://t.co/1F8fOxpaQ0 https://t.co/GaaGcF90YD

Links:

Dr. John Cush RheumNow ( View Tweet)
When DOACs (Xarelto, Eliquis) used for Afib or VTE, concomitant aspirin also given (without indication) in 34%. There was no additional anti-thrombotic effect, PLUS ASA use adds 20% increased risk of non-major bleeding. Registry cohort study of 3280 pts. https://t.co/6vDw8HfDZX

Links:

Dr. John Cush RheumNow ( View Tweet)

2016 FDA labeling discourage quinolones (tendinopathy, interstitial nephitis) use. Since QUIN Rx have steadily dropped for UTI, sinusitis & COPD with shift to nitrofurantoin, amoxil, macrolides & tetracyclines. Still QUIN used in 15-19% of UTIs and COPD https://t.co/Yq2c8YFUog

Links:

Dr. John Cush RheumNow ( View Tweet)

Did you miss yesterday's Tuesday Night Rheumatology? Watch the replay and see how we answered questions from the webinar attendees. https://t.co/WnnUklOmMP https://t.co/o2mRNZrUv8

Links:

Dr. John Cush RheumNow ( View Tweet)
News Feature: New Side Effect From mRNA COVID Vaccines? Herpes zoster reactivation following COVID-19 vaccination in 6 patients with comorbid autoimmune/inflammatory diseases may be a new adverse event associated with the Pfizer/BioNTech mRNA vaccine. https://t.co/GgjoIpYDkC https://t.co/sI2Fx0o05G

Links:

Dr. John Cush RheumNow ( View Tweet)
37 RA, 28 PsA & 20 AS pts in remission/LDA x 6 mos enrolled in DMARD spacing. Joint flares seen in 13.5% RA, 21.4% PsA & 20% axSpA pts but 5 more PsA patients had skin flare. PsA had lower persistence 61% (vs RA 87% & 80% AS) due to skin flares https://t.co/d1rMLTXSQs https://t.co/fNNSofWxgv

Links:

Dr. John Cush RheumNow ( View Tweet)
News Feature: Dr. Charles Christian of HSS Honored In the current issue of Annals of Rheumatic Disease, Dr. Peggy Crow honors the life and career of one the great, historic rheumatologists of all time: Dr. Charles Christian. https://t.co/UYOcR0QPc4 https://t.co/ML4snlVumB

Links:

Dr. John Cush RheumNow ( View Tweet)
55 pts w/ Multi-joint osteonecrosis (>2 jts).( SLE 29%, ALL 11%, HIV 9%, EtOH 4%). Mean cumulative steroid dose >30 g over 5 yrs. Predictors of MJON was cumulative oral steroid dose (3.2% incr per 1000 mg. MJON risk incr 12 X w/ 2nd risk factor https://t.co/dqTPh2PV8V https://t.co/HTrSnZSefK

Links:

Dr. John Cush RheumNow ( View Tweet)
Study of 207 Pediatric pts treated w/ Rituxan (for Rheum, Cancer, CNS, Renal dz) and 40% developed hypogammaglobulinemia post-RTX; hypo-IgG Pre-RTX 28.7% to Post RTX 42.6%, p=0.009; low IgG levels had higher risk of serious infx (OR 2.3) https://t.co/b91rPYgVV2

Links:

Dr. John Cush RheumNow ( View Tweet)

A Patient-Centered Exploration of Axial Involvement in SpA Sponsored by Novartis Medical Affairs Listen to a medical expert differentiate axial involvement within the spectrum of spondyloarthritis. https://t.co/o2q5pTP3WD https://t.co/GiqdIqitMB

Links:

Dr. John Cush RheumNow ( View Tweet)
Great reminder of from Dr. Kathryn Dao, @KDAO2011 from #RNL2021 Caution! Verrucous LE can simulate skin cancer! Both can be found in photosensitivity areas! #RheumNow

Dr. John Cush RheumNow ( View Tweet)

Shared from #RNL2021 from @uptoTate "Absence of proof of an effect is not proof of absence of an effect!" Dr. Kavanaugh's sage reminder for the day"

Dr. John Cush RheumNow ( View Tweet)

×