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New, Improved Therapy for Pompe Disease

d Jack Cush, MD

Researchers from the University of Cincinnati Gardner Neuroscience Institute will present data on a new treatment for Pompe disease at the American Academy of Neurology on April 20th; the results show that treatment with avalglucosidase alfa yielded substantial clinical improvements and a more favorable safety profile compared to the current standard of care (alglucosidase alfa).

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RheumNow Podcast – Combination Biologics

d Jack Cush, MD

Dr. Jack Cush serves up this week's news and articles from RheumNow.com.

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Planes, Trains and COVID Distancing

d Jack Cush, MD

MMWR reports the risk of acquiring an infection with SARS-CoV-2 is reduced 23% to 57% when the middle seat was vacant (compared with full aircraft occupancy).

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Autoimmune Risk of Death Up during COVID

d Jack Cush, MD

A population-based study in the UK shows that patients with rare autoimmune rheumatic diseases (RAIRD) were 44% more likely to die during the 2020 COVID-19 pandemic (March - April) compared to either the general population or their pre-COVID risk.

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Scoot over small molecule inhibitors, the future might be with nanoparticle targeting for RA! Dr. Fleischmann reviews study on nanoparticle targeting of CCP Ab that showed noninferiority to Tocilizumab #RNL2021 coverage from @KDAO2011

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BRAND NEW PODCAST-- Combination Biologics We talk about the articles featured on RheumNow this week. https://t.co/FFtYHhNJeM https://t.co/XCFMsZ6ttG

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#RNL2021 Coverage from Dr. Rachel Tate @uptoTate The good and the bad of HLA B27 iritis from Dr. Wang #RNL2021 -- 90% of patient maintain 20/40 vision or better with treatment -- BUT disease can relapse and can alternate between eyes

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Johns Hopkins myositis clinic: anti-mitochondrial Abs (AMA) found in 5% adult myositis, 1% of juv. myositis pts. AMA assoc. w/ severe muscle weakness, Raynauds, dysphagia, cardiomyopathy & treatment refractory Dz - Screening for cardiac & swallowing https://t.co/oj9kwHgTHf

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News Feature: USPSTF - No Need to Screen for Vitamin D Deficiency JAMA has published the new recommendation from the USPSTF stating that screening for vitamin D deficiency is unnecessary and unwarranted in asymptomatic adults. https://t.co/njeBeGgR7f https://t.co/vedK68MS0J

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ASSAIL-MI trial studied 200 pt with new (<6hr) STEMI-randomized to either PBO or IV 280 mg tocilizumab. While no signif difference in final infarct size (7.2 vs 9.1%; P=.08), TCZ treated pts had better myocardial salvage & less Microvascular obstruction https://t.co/WRRGXCbP5O

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Non-Hallmark manifestations of dermatomyositis include: panniculitis, diffuse subcutaneous edema, erythroderma, calcinosis, ulceration, flagellate erythema, Wong-type DM, gingival telangiectasias, and the ovoid palatal patch (full read) https://t.co/x6cdP3WDcW

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News Feature: NICE Guidelines on Chronic Pain Management Chronic primary pain is pain with no clear underlying cause, or pain (or its impact) that is out of proportion to any observable injury or disease. https://t.co/DV24wKBlEc https://t.co/8uxx4NC9W1

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"Don't check antibodies post vaccination! Most lab assays test anti-nucleocapsid antibodies from the virus and not the antibodies to the spike protein. Also we do not have data at what antibody level is protective or not protective. - Dr. J Curtis #RNL2021 @RADoctor "

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Smoking and RA are closely related. 50% of establish RA pts higher rate of smoking Smoking cessation - lowers RA disease activity #RNL2021

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Study of 2,842 participants in Osteoarthritis Initiative shows that a Western diet is associated with an increased risk of knee OA (HR =1.69), while a more prudent diet reduced risk of knee OA (HR = 0.70). 30% risk is mediated by high BMI https://t.co/24Dbwy9eJ5

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News Feature: Sinusitis Activity Linked to Brain Dysfunction Have you wondered why fibromyalgia, fatigue or cognitive dysfunction often co-associate with chronic sinusitis? https://t.co/Ow993w5Jb9 https://t.co/mYYDkDuJTv

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Calcinosis is associated with these autoantibodies - NXP-2, anti-PM/SCL and MDA-5 https://t.co/ORA2y1BWgn

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“Send a photo with the skin biopsy” - advice to rheumatologists by a dermatopathologist to help with path interpretation. #RNL2021 Great #RNL2021 notes from Dr. Kathryn Dao @KDAO2011

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Can Multiple Sclerosis and RA Coexist? What Drugs can be used? https://t.co/PYFQI7vn3M https://t.co/UQplGREDjf

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News Feature: IL-23 Targeting for Enthesitis in Psoriatic Arthritis Treatment with guselkumab (Tremfya) was effective in resolving enthesitis among patients with psoriatic arthritis (PsA), a post-hoc analysis of two phase III trials found. https://t.co/a6ypaa6Zxb https://t.co/zdRpZWIPAt

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