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Rheumatology Care Derailed by COVID-19

d Jack Cush, MD

A survey study from the  ArthritisPower PPRN or CreakyJoints database shows that during the COVID-19 pandemic patient care was substantially affected in unforeseen ways.

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Reactogenicity Following mRNA COVID-19 Vaccines

d Jack Cush, MD

JAMA has published the real-world reporting of mRNA vaccine side effects (reactogenicity) gathered from CDC V-safe Surveillance system and shows that local and systemic reactions were often mild and transient and most commonly seen during the first day following their second dose.

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Cost Efficacy of Knee Replacement in Obese Osteoarthritis

d Jack Cush, MD

Total knee replacement (TKR) in obese patients with end-stage knee osteoarthritis appears to be a beneficial and cost-effective strategy for treating. The only potential limitation is a greater risk for adverse events in those with a body mass index (BMI) of 40 kg/m2 or greater.

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Rituximab in Systemic Sclerosis?

d Jack Cush, MD

No drug is FDA approved to manage the skin or joint complaints of systemic sclerosis (SSc); a recent metanalysis suggests that rituximab may improve skin score and disease activity indices (DAS, mRSS) while stabilizing organ involvement in SSc patients.

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From @KDAO2011-- "Is it better to taper the steroids or leave it? SEMIRA study. Tapering off low dose steroids cause more flares and more treatment side effects. Dr. Buttgereit says keep your low dose steroids (prednisone 5 mg/day or less) https://t.co/RAYkVxGO9N #RNL2021"

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CDC updates its COVID Comorbid Dz list to include type 1 diabetes (& NIDDMA), mod-severe asthma, liver Dz, dementia , stroke/cerebrovascular disease, HIV infxn, cystic fibrosis, obesity, substance use disorders (NOT ARTHRITIS, PSORIASIS) https://t.co/LbVMVGf4IR

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Cox-2 inhibition (Celebrex 200 mg bid) added to standard chemoRx (FolFox) in pts w/ stage III colon cancer failed to improve survival at 3 yrs - DB, RCT vs placebo; 3 yrs Dz free survival was Celecoxib 76% vs PBO 73% (HR 0.89; 95% CI, 0.76-1.03; P = .12) https://t.co/81L33QLa9d https://t.co/EQXgwMcgtd

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News Feature: US Senate Introduces the Safe Step Act #RheumNow https://t.co/5SPTIXnJCS https://t.co/DtmrlJMXL9

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Beijing study of 207 RA patients starting DMARD and steroids (GC) shows after 3 years only 59% D/C GC (mean was 24 mos). Odds of stopping GC were 10% @ 6mos, 27% @Yr1, 48% @Yr 2 and 59% at 3 years. https://t.co/E2RchB9IAs https://t.co/uDEAqaM8GC

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Interesting case with unilateral sacroilitis - potential mimics include: Paget disease, diffuse idiopathic skeletal hyperostosis, sarcoidosis, infections [3], and also bone and hematologic tumors. What did this man have? https://t.co/Uu0kJxeJtn

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New podcast up! Download wherever podcasts are available. Upadacitinib Wins in PsA Dr Jack Cush reviews the news and Journal reports and takes "Back Talk" questions from viewers. https://t.co/ZMAUgn10dU https://t.co/QTDqZW3GgG

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Another study suggests poorer outcomes in Rheum pts on Rituximab. French Cohort study of 1090 inflammatory rheumatic MSK pts -13% w/ severe COVID-19 & 8% who died. 63 RTX pts had more severe disease, longer hosp stays & more death (21% vs 7%) https://t.co/5UCvFeVWRS

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#RNL2021 insight from the Lupus panel--originally tweeted by @KDAO2011 "Lupus panniculitis feels like wood: mummified degenerative fat replaced by fibers " #RheumNow

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Interestng overview/read on the Inflammasome - its history, clinical targeting and new inflammasome (NLRP3) inhibitors in development by pharma. https://t.co/DEdP09GZd7

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Are you signed up for the RheumNow daily newsletter? Head over to RheumNow and sign up to have the news delivered to your inbox daily. https://t.co/HSBjF6ySNv

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#RNL2021 coverage from @uptoTate "Dr. Robert Wang: 91% of uveitis is non-infectious and located in the front of the eye - "anterior uveitis/iritis." 50% of anterior uveitis patients are +HLA B27! " #RheumNowLive

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News Feature: Upadacitinib Clinical Efficacy in Psoriatic Arthritis https://t.co/gdAnqEFk3n https://t.co/PNYwhRFTEK

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Thanks @doctorRBC for sharing this from #RNL2021 "Dr. N Haroon talking about SpA treatment -TNFi can reduce spinal radiographic progression -Better to taper biologics in AxSpA than stopping -JAKinibs are coming "

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News Feature: HLA B27 Iritis - RNL 2021 Highlights by Dr. Rachel Tate ( @uptoTate ) #RNL2021 #RheumNow https://t.co/SlftHnhD6z https://t.co/utjOU0rfBP

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News Feature: Inflammatory Conditions Up the Risk of Premature Myocardial Infarction https://t.co/gbPpAYJGFg https://t.co/ValdJWGyxl

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