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Will AI put me out of a job?

Adela Castro, MD Feb 11, 2025

The development of AI and other technologies brings new possibilities for optimizing diagnosis, management and has potential for improving outcomes in RA. At RheumNow Live 2025, Dr. Jeff Curtis, University of Alabama at Birmingham, presented a talk on, "AI applied to Rheumatoid Arthritis Care: Practically (Not) Perfect".

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Obinutuzumab Efficacy in Active Lupus Nephritis

Jack Cush, MD Feb 10, 2025

A phase 3, randomized controlled trial of an anti-CD20 monoclonal antibody, obinutuzumab, was shown to be effective and safe in patients with active lupus nephritis.

TheDaoIndex @KDAO2011 Late onset RA (LORA) aka RA diagnosed at an older age — pts have higher inflammatory markers, presents like PMR; they also have polypharmacy, comorbidities, frailty, etc that can complicate management @UnaMakris #RNL2025 @RheumNow #GeriRheum… https://t.co/E2WFwfCsWD https://t.co/tKF0OnUFQH

Obinutuzumab Efficacy in Active Lupus Nephritis A phase 3, randomized controlled trial of an anti-CD20 monoclonal antibody, obinutuzumab, was shown to be effective and safe in patients with active lupus nephritis. https://t.co/e1cDvJcC9g https://t.co/HUDd1ocAvc

Obinutuzumab Efficacy in Active Lupus Nephritis | RheumNow

Eric Dein @ericdeinmd AI models require good Positive Predictive Value (PPV) But: PPV decreases as prevalence decreases - In choosing a successful biologic: Harder to predict more challenging patients (multiple failures, co-morbidities, etc) - ACR50 non-response is higher J… https://t.co/eAOR0jFmO3 https://t.co/TB6Ecd8nZh

-HS ttx👇 1. Lifestyle changes: smoking cessation, obesity. 2. Management of comorbidities. 3. 🔍HS- related autoimmune disorders. 4. FDA approved biologics: -Adalimumab (PIONEER 1&2) -Secukinumab (SUNRISE, SUNSHINE) -Bimekizumab (BE HEARD 1&2) "Theres no such… https://t.co/G5Voxrm3Kt https://t.co/dLGtoFZMd1

Combination therapy in PsA . Regulatory and reimbursement issues may inhibit such strategies (and potential adverse event concerns) but anecdotal evidence would suggest a role in difficult to treat cases. @RheumNow #RNL2025 https://t.co/IIoUiJyP95

https://x.com/RichardPAConway/status/1888326939146092638/photo/1

#RNL2025 @RheumNow JAKi in DM: @JuliePaikMD- 10 DM pts open label on JAKi. 7/10 improved from mod/severe to mild. In 96wk extension, 6 of 7 continued response 145 case reports for tofa, bari, ruxolitinib. Role in helping calcinosis? Pruritu? Brepocitinib (JAK1/TYK2i) study

#HOT #topic Will #Rx of #PsO PREVENT onset of #PsA Well, maybe 🤔 Alexis R Ogdie ⁦@RheumNow⁩ #RNL2025 70% of #psoriatic #arthritis is preceded by #psoriasis Still a bit of a debate re prevention of PsA https://t.co/7bce8kcjdr

https://x.com/Janetbirdope/status/1888270031428972772/photo/1

FDA has approved Journavx (suzetrigine) 50 mg tablets, 1st in-class non-opioid analgesic, to treat moderate to severe acute pain in adults. Journavx reduces pain by targeting a pain-signaling pathway involving sodium channels in the peripheral nervous system, before pain signals… https://t.co/qjtr4yz8Ot https://t.co/RUZmLgsmTv

Break a leg! Or a #hip #AVN risk occurs even at 1 month of high / moderate dose #glucocorticoids Shown by Michelle Petri @RheumNow #RNL2025 Risk in SLE is likely 👇 #disease #activity And #steroids #SLE #systemic #lupus #erythematosus #steroids https://t.co/4EsQw9tY1u

https://x.com/Janetbirdope/status/1888260390674407819/photo/1

Even a #SLE expert who wants all #lupus Pts on No #chronic #prednisone Realizes you can’t get everyone off #glucocorticoids 18% May be on chronic #steroids But she keeps trying to taper Michelle Petri #RNL2025 @RheumNow https://t.co/SNP6Eep731

https://x.com/Janetbirdope/status/1888265132968493079/photo/1

M. Petri on Steroids in SLE👇 -Organ damage is higher in AA vs Caucasians-driven by CS -CV risk increase is dose dependent: >10 mg =2x risk >20mg =5x risk -Increase prednisone by 10mg =30% increased risk for organ damage! 🤯 -20mg/day >1m increases risk for… https://t.co/fZVjS7JQBL

https://x.com/i/web/status/1888260985720295639

Wise person once said If you don’t take your medications, THEY DON’T WORK! Shocking 1 in 3 nonadherence with #hydroxychloroquine By drug levels In young Pts with #SLE #lupus Michelle Petri @RheumNow #RNL2025 https://t.co/H5izbnW0qU

https://twitter.com/kdao2011/status/1888260240312865152

Michele Petri @RheumNow #RNL2025 1 mg of prednisone -> 3% increased risk of damage Taper quickly, withdrawal slowly Make sure background therapy is on - monitor therapy with HCQ levels, early use of additional Rx https://t.co/pjFNcg99ed

https://x.com/ericdeinmd/status/1888269093851009278/photo/1

Who’s liable for an incorrect #AI diagnosis or medical advice? @rheumnow #RNL2025 @RADoctor

AI models require good Positive Predictive Value (PPV) But: PPV decreases as prevalence decreases - In choosing a successful biologic: Harder to predict more challenging patients (multiple failures, co-morbidities, etc) - ACR50 non-response is higher J Curtis @RheumNow #RNL2025 https://t.co/SdJ0FHVuSC

https://x.com/ericdeinmd/status/1888226866923798734/photo/1

Late onset RA (LORA) aka RA diagnosed at an older age — pts have higher inflammatory markers, presents like PMR; they also have polypharmacy, comorbidities, frailty, etc that can complicate management @UnaMakris #RNL2025 @RheumNow #GeriRheum https://t.co/zqEcyg2ejw

https://x.com/KDAO2011/status/1888228907955941861/photo/1

Can #AI help us determine the 👇 Right drug At Right time Pipe dream? Or to use #artificial #intelligence term ➡️ a #hallucination? garbage in ➡️➡️garbage out Most predictions of drug response are same: multimorbid multiRx failures Nonadherent poverty #RNL25 @RheumNow https://t.co/70SRp8BnCl

https://x.com/Janetbirdope/status/1888229822125559868/photo/1

Facing challenges in diagnosing idiopathic inflammatory myopathies? Check out our recent webinar to hear from Stanley J. Naides, MD, FACP, FACR, as he explores the role of autoantibody testing in autoimmune myositis diagnosis and phenotyping. Sponsored by LabCorp Rx. #Myositis… https://t.co/4jMevolO3k https://t.co/ObWPR8QFW2

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Will AI put me out of a job?

Obinutuzumab Efficacy in Active Lupus Nephritis

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