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ANA+ consult (10.18.2024)

Jack Cush, MD

Dr. Jack Cush reviews the news and journal articles from this past week on RheumNow.com.

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Alendronate Atypical Fractures Back In Court

Jack Cush, MD

Reuters reports that a U.S. appeals court on Friday revived more than 500 lawsuits alleging that Merck failed to warn that patients taking alendronate for osteoporosis may be at increased the risk of atypical femoral fractures.

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Inadequate Zoster Vaccination in Immunocompromised Patients

Jack Cush, MD

A VA study of shows that recombinant zoster vaccine (RZV) vaccination in immunocompromised patients or those receiving immunosuppressive medications is insufficient, given these are high risk individuals.

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Dot the "i", Cross the "t" (10.11.2024)

Jack Cush, MD

Dr. Jack Cush reviews the news and journal articles from the past week on RheumNow.com. Today’s reports suggest where to look for help, especially with regard to pain.

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Screening to Prevent Multimorbidity in Rheumatic Patients

Jack Cush, MD

A population based screening program of patients with chronic inflammatory rheumatic diseases (IRD) demonstrates that systematic screening IRD patients for multimorbidity increased preventive interventions and reduced hospital admissions. 

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ED Delays and Hip Fracture Mortality Risk

Jack Cush, MD

Waiting more than 4 hours in emergency care for treatment is linked to heightened risks of death and a longer hospital stay for hip fracture patients, reveals a single centre study, published online in Eme

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Analgesic Prescribing in Patients with Inflammatory Arthritis

Jack Cush, MD

A UK cross-sectional EHR clinical practice analysis between 2004 and 2020 shows that analgesic prescribing in inflammatory arthritis (IA) patients has declined, but still remains substantial, including opioid prescribing. 

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Stop Counting Bugs (10.4.2024)

Jack Cush, MD

Dr. Jack Cush reviews the news and journal articles from the past week on RheumNow.com.This week’s rants include the microbiome, PsA treatment choices and fishing for P-values in research.

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Long Term Antibiotics Increase Risk of RA

Jack Cush, MD

JAMA has published a population-based retrospective cohort study showing a possible association between the long-term use of antibiotics and the risk of rheumatoid arthritis (RA).

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Men and Women Process Pain Differently Men and women experience pain relief differently; a new study may help explain why women have more chronic pain and are less responsive to opioid treatments. https://t.co/MYWAZnqGmA https://t.co/TxofSlsI4M

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Upadacitinib safety across in RA, PsA, AS, atopic dermatitis >15000 Pt-Yrs exposure. Rates (per 100PYs) of Hzoster (1.6–3.6), NMSC (0–0.8) & incr CPK (4.4–7.9) higher w/ UPA vs comparators (RA, PsA); Deaths (0–0.8), SIE (0–3.9), MACE (0–0.4), VTE (<0.1–0.4), CA, malignancies… https://t.co/OoJ5OX7JyL https://t.co/vaMVFmldEB
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Risk of Uveitis with Spondyloarthritis A retrospective registry study shows that uveitis may be seen in 10% with the diagnosis of axial spondyloarthritis (axSpA) but becomes more common (47%) over the next 30 years of disease. The good news is that biologic therapy can… https://t.co/96rRu77Tyl https://t.co/bGHnZ7lCIm
Dr. John Cush RheumNow ( View Tweet)
Long Term Antibiotics Increase Risk of RA JAMA has published a population-based retrospective cohort study showing a possible association between the long-term use of antibiotics and the risk of rheumatoid arthritis (RA). https://t.co/U7lPvTSJWO https://t.co/MrUuP6crB7

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Dr. John Cush RheumNow ( View Tweet)
ED Delays and Hip Fracture Mortality Risk Waiting more than 4 hours in emergency care for treatment is linked to heightened risks of death and a longer hospital stay for hip fracture patients, reveals a single centre study, published online in Emergency Medicine Journal.… https://t.co/ZaIEkb7Lo5 https://t.co/P15DrXMbnj
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World renowned faculty delivering state of the art lectures. Early bird registration for RheumNow Live is now open! https://t.co/Yk8dKDdZie https://t.co/d14Mq2AxlI

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Analgesic Prescribing in Patients with Inflammatory Arthritis A UK cross-sectional EHR clinical practice analysis between 2004 and 2020 shows that analgesic prescribing in inflammatory arthritis (IA) patients has declined, but still remains substantial, including opioid… https://t.co/K43YERU3rf https://t.co/DRZ4r9JDSv
Dr. John Cush RheumNow ( View Tweet)
Appraisal of 2023 ACR RA-ILD guidelines (based on only 3 RCTs). Conditional Recs for MMF, AZA, RTX as 1st-line RA-ILD Rx. W/ RA-ILD progression, options include MMF, RTX, nintedanib, TCZ, CTX, & pirfenidone are conditionally recommended https://t.co/9M3XykPQIi https://t.co/S0TMCsVd4y

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French cohort study shows that epidermal necrolysis (EN) is a rare, but assoc w/ high rates of in-hospital and postdischarge mortality, esp in elderly and those w/ comorbid conditions. https://t.co/BaMZmer0Fa https://t.co/mrUO419GLP

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Korean Claims analysis of 413 radiographic axial spondyloarthritis (TNFi exposed=75 ). Recurrent CV events = 32 per 1,000 person-years; but lower if TNFi Rx'd = 19/1000PYs. TNFi exposure significantly lowered risk of recurrent CV events https://t.co/f69SHpXZCx https://t.co/ofpg0JbrR1

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JAMA metaanalysis of psoriasis pts (40 RCTs, 21 438 pts) Rx w/ biologics: a >=90% PASI (skin) response was less likely with older age, prior biologics, higher BMI, and smoking https://t.co/v5EpOpYVYt https://t.co/wXTXP76Emu

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