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ICYMI: Actemra FDA Approved for Systemic Sclerosis Interstitial Lung Disease

d Jack Cush, MD

Genentech announced Thursday that the US Food and Drug Administration approved tocilizumab (Actemra) for the treatment of Systemic Sclerosis-associated Interstitial Lung Disease (SSc-ILD), specifically indicated for slowing the rate of decline in pulmonary function in adul

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ICYMI: Cardiac and Cancer Signals Tofacitinib Safety Alert from FDA

d Jack Cush, MD

The FDA has notified healthcare professionals of a safety alert concerning tofacitinib (Xeljanz), noting that preliminary results from a long-term safety clinical trial show an increased risk of serious heart-related problems and cancer with tofacitinib (compared to adalimumab) when given to at-risk rheumatoid arthritis patients. These findings are in addition to the thrombotic risks (added to the label), potential risks including blood clots in the lungs and death.

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ICYMI: JAK Inhibitor Misses Endpoint in Safety Study. Now What?

d MedPage Today

Pfizer announced results Wednesday from its FDA-mandated postmarketing safety study of tofacitinib (Xeljanz), and they don't bode well for the drug and possibly others in its class.

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RheumNow Podcast – As Good As I Ever Was (7.2.2021)

d Jack Cush, MD

Dr. Jack Cush reviews the news and journal reports from this past week on RheumNow.com.

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ProDERM Study: IVIG in Dermatomyositis--The ProDERM study show that IVIg is safe, effective and superior to placebo in patients with dermatomyositis (DM). https://t.co/HOB8CYn9yc https://t.co/4nNRRhzHVO

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Is Q-DAPSA the answer to disease activity scoring in PsA? Dr. Rachel Tate ( @uptotate) provides some insight. https://t.co/fbi3Kbd2GS https://t.co/vBhWsbQYlg

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Dr. John Cush RheumNow ( View Tweet)
"Arthritis Mutilans" - worse outcome to chronic inflammatory arthritis is due to 5 disorders: 1) RA 2) Psoriatic arthritis 3) Tophaceous gout 4) polyarticular JIA 5) Multicentric reticulohistiocytosis (Ive never seen this!!) https://t.co/XYmBEW1F0R https://t.co/010QYkOO7E

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Dr. John Cush RheumNow ( View Tweet)
Serious problem! Pulmonologists believe that MTX causes and/or worsens ILD. MTX causes hypersensitivity pneumonitis, not ILD. RA, lupus DM, PSS cause ILD and they may need MTX to manage their disease. Do your own research, look at this paper to start. https://t.co/vUyCxJP2Mh

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Protective Effects of Colchicine in Non-Hospitalized COVID-19 A press release from the Montreal Heart Institute has announced that the COLCORONA clinical trial has provided evidence of the protective effect of colchicine. Read more: https://t.co/xW5SchMUeK https://t.co/tUoDTJKbVG

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Psoriasis has greatest risk of MTX liver dz - a Danish Population study of PsO, PsA & RA pts taking MTX. Risk of liver Dz was most in PsO, followed by PsA, then RA. PsO had 1.6-3.4 fold risk (mild-severe) liver dz (vs RA). PsA was 1.3-1.6x higher) https://t.co/pAo9KFr5fO

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1/3 of patients with rheumatoid arthritis had unacceptably high levels of pain 5 years after diagnosis, often despite low levels of inflammation, Swedish researchers found. Read more: https://t.co/K8zf1pE9jM https://t.co/eu2Byo6dx4

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Dr. John Cush RheumNow ( View Tweet)
The ACR has a new position on patient safety and site of service for biologics— it strongly believes infusions should be given in a monitored health care setting with onsite supervision by a provider w/ training in biologic infusions. https://t.co/NONozoIIq6 https://t.co/PQMvUZqnMW

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A study of rheumatologists in Ontario, Canada has shown an increasing percentage of women in rheumatology; unfortunately they have lower salaries but see fewer patients than do their older, male colleagues. Read more: https://t.co/JM0345p8f1 https://t.co/y95LQ6lX5i

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Dr. John Cush RheumNow ( View Tweet)
Download this week’s podcast titled “Good as I Ever Was”. You can find us on SoundCloud and wherever you download your podcasts. https://t.co/hVMf8X5Dx3 https://t.co/uUDCXzO2eU

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New ACR Rheumatoid Arthritis Guideline: Emphasis on Methotrexate https://t.co/J9wmcZr17D

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How risky are family gatherings, birthday parties and informal social gatherings? Read more… https://t.co/jyGHakndUt https://t.co/7eps0EFVWy

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Brand new RheumNow podcast up titled “As Good As I Ever Was” Download now. https://t.co/hVMf8X5Dx3 https://t.co/2R2kq7dwp5 https://t.co/5mahn4D46M

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Dr. John Cush RheumNow ( View Tweet)
Therapeutic Drug Monitoring for Infliximab: Might it Actually Work? https://t.co/Onl6cijKbb https://t.co/jnwx4ZZvhz

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Dr. John Cush RheumNow ( View Tweet)
Ten Things to Tell Patients About Diet and Rheumatic Disease https://t.co/DpBAJwCJCY https://t.co/AVlgHfdP08

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Dr. John Cush RheumNow ( View Tweet)
With the expansion of knowledge regarding the safety of newer agents in pregnancy comes the PreCARA study showing that when pregnancy is planned and patients with RA are treated with a modified T2T approach, superior outcomes can be anticipated. Read on: https://t.co/sV5hJRzPJW https://t.co/ADppVd3CmZ

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Dr. John Cush RheumNow ( View Tweet)
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