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Italian PsABio cohort study: UST ⬆️ overall persistence vs TNFi, especially in females, in monotherapy, BMI <25 or >30 kg/m2, & UST as 2nd-line tx. At 1 year, both UST & TNFi pts showed similar cDAPSA & MDA/VLDA. Abstract #POS1021 #EULAR2021 @RheumNow https://t.co/DGRXmPiTiD https://t.co/s7zMuSBEWt
Dr. Rachel Tate uptoTate ( View Tweet)
More data from @rheum_covid presented by @mugartegil showing prognostic factors in patients with SLE & COVID-19
Factors related with poor prognosis:
-Male, Age, Comorbidities
-Time period (1st wave)
-GC doses
-Disease activity
- No enough data for RTX or Beli
#EULAR2021
#LUPUS https://t.co/ts8QsyR5KA
José A. Gómez Puerta DrGomezPuerta ( View Tweet)
What is the highest level reaction you have seen to COVID vaccine? @RheumNow #EULAR2021
Richard Conway RichardPAConway ( View Tweet)
Dr Pupim presents data on GM-CSF inhibitor mavrilimumab to treat non-ventilated COVID-19 with systemic hyperinflammation 65% ⬇️ ventilation/death day 29 (p=0.02) 61% ⬇️ death day 29 (p=0.07) @RheumNow #EULAR2021 Abstr#LB0001 https://t.co/VBPyv4Kbv7
Richard Conway RichardPAConway ( View Tweet)
Dr Ruperto on secukinumab in ERA and JPsA subtypes of JIA. HR 0.28; 95%CI 0.13–0.63 p<0.001 for flare to week 100. 87.2%, 83.7%, 67.4%, 38.4% and 24.4% of pts achieved JIA ACR 30/50/70/90/100 @RheumNow #EULAR2021 Abstr#LB0004 https://t.co/envFupqqV2
Richard Conway RichardPAConway ( View Tweet)
Dr Diekmann presents on rheumatic irAEs in different cancers. More common melanoma than NSCLC. SpA most common. Occurrence associated better tumour response. Good response to immunosuppression @RheumNow #EULAR2021 Abstr#POS0293 https://t.co/0tSHSbRq40
Richard Conway RichardPAConway ( View Tweet)
Dr Chatzis presents risk prediction model for MALT lymphoma in Sjogrens. Cryoglobulinaemia and ESSDAI at diagnosis only predictors. AUROC 0.78 for model @RheumNow #EULAR2021 Abstr#POS0290 https://t.co/cLmiMgnpwF
Richard Conway RichardPAConway ( View Tweet)
Quiz yourself.
Which of the following is NOT a risk factor for HCQ associated conduction abnormalities? #EULAR2021 @RheumNow
k dao KDAO2011 ( View Tweet)
Deep learning for SLE #POS0351
👉use of AI to ID potential targets/dz pathways
👉gene ranked using metric expression & interactivity
👉many IFN and JAK/STAT genes ranked high
👉strong assc w/new pathways related to CD4+Tcell different'n, macs, denditric cells #EULAR2021 @rheumnow https://t.co/JF7NFeX4E7
k dao KDAO2011 ( View Tweet)
Not an expert in capillaroscopy? Not an issue! https://t.co/jHNKDtafQC: an automatic image reading system able to detect:
-Normal capillaries Se 79.8% Spe 82%
-Megacapillaries Se 89.4% Spe 78.8%
-Hemorrhages (Se 71% She 73.9%) compared to expert
#POS0256 #EULAR2021 @Rheumnow https://t.co/MR8enBO0de
Aurelie Najm AurelieRheumo ( View Tweet)
Wait, let me scan your joints first! Early arthritis clinics: US examination prior first clinical review in cohort of 163: ⬇️
⭐️time to diag from mean 31 days to 12
⭐️n° of clinical visits - 114 visits over a year
⭐️n° of revised diag at 1yr 5 vs 16% #POS0260
#EULAR2021 @Rheumnow https://t.co/CLkNqZUJVQ
Aurelie Najm AurelieRheumo ( View Tweet)
Subclinical US enthesitis in 174 IBD patients w/ or w/out PSO:
-High prevalence of structural damage ≥1 enthesis 83.4%
-≥1 active enthesitis 25%
in IBD + PSO:
-⬆️ ≥ 1 thickened enthesis 86% vs 64% p=0.009)
-⬆️of PD signal at knee examination.
#POS0265 @RheumNow #EULAR2021 https://t.co/8f7G5ku1kc
Aurelie Najm AurelieRheumo ( View Tweet)
Adelphi RA Disease Specific Program: Physician survey on T2T strategy implementation in RA. #POS0305
What is main objective in RA T2T?
@Rheumnow #EULAR2021
Aurelie Najm AurelieRheumo ( View Tweet)
ESPOIR cohort 598 patients w/ EVA fatigue for 10yrs: 3 fatigue trajectories high, moderate and low, consistent over time. Predictors of high fatigue trajectory: female gender, pain, psychological distress, presence of sicca symptoms. Effect of tmts? @Rheumnow #EULAR2021 #POS0308 https://t.co/iMLKFPikaR
Aurelie Najm AurelieRheumo ( View Tweet)
Depression is not only associated with high PGA but also with inflammatory markers in RA! Cross-sectional study of 258 patients: Depression (PHQ-9>10) associated with DAS28-ESR OR 1.1, DAS28 CRP OR 1.1, PGA AND CRP OR1.3 in multivariate analysis.
@Rheumnow #POS0312 #EULAR2021 https://t.co/66CaqLp61r
Aurelie Najm AurelieRheumo ( View Tweet)
Is genetic of RA remission different? Neither genetic risk score comprising RA susceptibility variants (OR 0.99 0.94-1.03) nor HLA-SE (OR 0.8 0.75-1.01) are associated with DAS28CRP<2.6 at 6 month in this MA of 8 inception cohorts (4425 patients) @RheumNow
#EULAR21 POS0348 https://t.co/rvGovxTlRo
Aurelie Najm AurelieRheumo ( View Tweet)
In a new scientific era dominated by high throughput technologies, statistical analysis is at least as important than samples quality. Different data modeling strategies applicable to ScRNASeq discussed by Dr @YvanSaeys in the #EULAR2021 Investigative Rheumatology. @Rheumnow https://t.co/eMcNfWIxM2
Aurelie Najm AurelieRheumo ( View Tweet)
EUSTAR database: in 474 patients w/ no baseline ILD, t0 DLCO value<80% predicted ILD on HRCT at 2years w/ OR 3.1 [1.49-6.40]p=0.0023 while t0 FVC value<80% didn't reach statistical significance OR 1.95 p=0.13. To be confirmed in prospective studies! @RheumNow #EULAR2021 #POS0317 https://t.co/haNlN0OfX4
Aurelie Najm AurelieRheumo ( View Tweet)
COVAX Registry: 1519 patients w/ 51% IA, 45% CsDMARDs, 36% bioDMARDs, 31% GCs; vaccinated with Pfizer, AZ or Moderna. Overall, very reassuring safety profile. 5% flares. Efficacy to trigger AB response needs to be further assessed.
@pedrommcmachado #LB0004 @Rheumnow #EULAR2021 https://t.co/1dSfOJALzf
Aurelie Najm AurelieRheumo ( View Tweet)
Dr Furer on immunogenicity of Pfizer vaccine in RMD. Most good responses. GC, rituximab, MMF, abatacept blunt response. @RheumNow #EULAR2021 Abstr#LB0003 https://t.co/Lq4kx7B5bJ
Richard Conway RichardPAConway ( View Tweet)
