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Serious Infection Risk High in Patients With Lupus

d MedPage Today

Patients with systemic lupus erythematosus (SLE) had two to four times higher risk for serious infection requiring hospitalization, a nationwide Swedish study found.

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RheumNow Podcast – Do More DMARDs Mean More Switching? (9.17.2021)

d Jack Cush, MD

Smartphones and diet; COVID-19 and the numbers - reassuring or not, and what about masks?; and do more drugs mean more switching, less persistence, and patient adherence goes up...or down? All this and more news and journal reports in this week's episode.

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"In medical school, they spend days teaching people to operate on lungs, and no time at all helping young doctors learn how to get their patients to stop smoking and get vaccinated." - Seth Godin https://t.co/YIk0O0kDTB

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Dr. John Cush RheumNow ( View Tweet)

Patients with systemic lupus erythematosus (SLE) had two to four times higher risk for serious infection requiring hospitalization, a nationwide Swedish study found. https://t.co/ilkqTtZjVL #RheumNow https://t.co/hzcqlNUF66

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Dr. John Cush RheumNow ( View Tweet)
ICYMI: American College of OBs & GYNS and the Society for Maternal-Fetal Medicine both enthusiastically endorse COVID Vaccination of pregnant women, given the delta variant, low vax rates in Preg women and poor COVID outcomes in preg. https://t.co/AmP5eOEgr3 #RheumNow https://t.co/wXeT1KDCrJ

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Dr. John Cush RheumNow ( View Tweet)
ICYMI: Gitelman syndrome (GS) is common salt-wasting genetic tubulopathy causing hypokalaemia and hypomagnesemia. Chondrocalcinosis (CC) is a frequent feature of GS. Study of 57 GS pts - 79% had CC, esp in Cx spine, Knee & wrist. https://t.co/ctEAQq1zzL #RheumNow

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Dr. John Cush RheumNow ( View Tweet)

In case you missed it… Breakthrough COVID infection. Breakthrough brilliance in a KOL A must read from Len Calabrese https://t.co/2Ljzau5nBG #RheumNow

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Dr. John Cush RheumNow ( View Tweet)

We've got a new podcast available for download! Dr Jack Cush reviews the news and journal reports and takes cases and questions from rheumatologists. https://t.co/ErJJ5XL8NA #RheumTwitter #RheumNow #medtwitter https://t.co/tqyVNyNYa4

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Dr. John Cush RheumNow ( View Tweet)
ICYMI: Population study shows risk of H. Zoster in adults to be high among bDMARD and CTX, also increased w/ AZA and HCQ but not MTX SSZ or LEF users. Data from 254065, 1,826311 Pt-Yrs F/U, 6295 new DMARD users, 17024 incident HZ https://t.co/1TeOAWN9LB #RheumNow

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Dr. John Cush RheumNow ( View Tweet)

ICYMI: Probenecid, an OAT3 inhibitor, has inhibitory effects on RNA viruses (influenza, RSV) & decreases ACE2 expression. May have utility in COVID-19 as it was shown to inhibit SARS-CoV-2 replication in animal models https://t.co/MClSjpqpSa #RheumNow

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Dr. John Cush RheumNow ( View Tweet)

Do More DMARDs Mean More Switching? Tune in to this week's podcast to find out. https://t.co/ErJJ5XL8NA #RheumNow #RheumTwitter #medtwitter https://t.co/5Ufk0XQbmb

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Dr. John Cush RheumNow ( View Tweet)
Looking for Rx updates? We’ve got them for you. https://t.co/FOfqUvZ8nx

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Dr. John Cush RheumNow ( View Tweet)

ACR Responds to 2022 Medicare Physician Fee Schedule Proposed Rule Read more: https://t.co/SVGhfhp6Fg #RheumNow #RheumTwitter #medtwitter https://t.co/g46wYCdary

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Dr. John Cush RheumNow ( View Tweet)
Breakthrough COVID infection. Breakthrough brilliance in a KOL A must read from Len Calabrese https://t.co/2Ljzau5nBG

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Dr. John Cush RheumNow ( View Tweet)

A retrospective records review of patients with periodic fever syndromes (PFS) receiving IL-1 inhibitor treatment with canakinumab (CAN), shows CAN to be effective and safe in a variety of PFS patients. https://t.co/4lqMhE6ikx #RheumNow #RheumTwitter #medtwitter https://t.co/yThiwJhcwO

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Dr. John Cush RheumNow ( View Tweet)
32 RA pts; each w/ 2 stool samples >6 mos apart - stool metagenome sequencing stool samples and pt activity assessed. Microbiome most influenced by age, followed by those achieving minimum clinically important improvement https://t.co/unaEOOuP34

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Dr. John Cush RheumNow ( View Tweet)

Gitelman syndrome (GS) is common salt-wasting genetic tubulopathy causing hypokalaemia and hypomagnesemia. Chondrocalcinosis (CC) is a frequent feature of GS. Study of 57 GS pts - 79% had CC, esp in Cx spine, Knee & wrist. https://t.co/ctEAQq1zzL

Links:

Dr. John Cush RheumNow ( View Tweet)

Another non stellar result for remdesivir Remdesivir plus standard of care versus standard of care alone for the treatment of patients admitted to hospital with COVID-19 (DisCoVeRy): P3, randomised, controlled, open-label trial ⁦@TheLancetInfDis⁩ https://t.co/kNSNj9RM4K

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Dr Philip Robinson philipcrobinson ( View Tweet)

#ACR21 abstracts now online! NOTE: To coincide with virtual meeting early access, information that goes beyond that contained in the abstract is under embargo until Nov. 1 at 10 AM ET. Browse → https://t.co/o0fpZCHZLC https://t.co/SaNrNQPgau

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American College of Rheumatology ACRheum ( View Tweet)
#ClinicalPearl Two risks for developing #psoriatic arthritis. Scalp involvement and nail involvement. Yes the patient has PsA https://t.co/sG4DueDtVy
Janet Pope Janetbirdope ( View Tweet)
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