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COLCORONA: Protective Effect of Colchicine in COVID-19

d Jack Cush, MD

Lancet Respiratory Medicine has reported the results of the COLCORONA trial, showing that in patients with PCR-confirmed COVID-19 infection, colchicine led to a significantly lower rate of death or hospital admission from COVID.

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RheumNow Podcast – Heart, Lung & Liver (5.28.2021)

d Jack Cush, MD

Dr. Jack Cush reviews the news and journal reports from this past week on RheumNow.com.

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Methotrexate Impairs COVID Vax Response

d MedPage Today

One-third of patients with immune-mediated inflammatory diseases being treated with methotrexate showed attenuated responses to the COVID-19 vaccine, researchers reported.

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Study of National inpatient sample database (2015 to 2017) showed the frequency of atrial fibrillation in rheumatic disease (RD) pts finding that AF frequency highest in gout followed by vasculitis, and PMR. RD Mortality was 2 fold higher with AF. https://t.co/enno6hrKOI

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A trial of sarilumab in 431 hospitalized COVID-19 patients on supplemental oxygen, Compared to placebo, sarilumab did not improve COVID outcomes https://t.co/postv1eK3F

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Kidney biopsies in patients with lupus – how early and how often? Dr. Fogo and Dr.Hogan explain why a kidney biopsy is critical for diagnosis and characterization of kidney involvement by SLE #SLEEducatorsNetwork. Sponsored by GSK US Medical Affairs https://t.co/ta3hliB9ls https://t.co/hJE6BNlNqk

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Pirfenidone, studied in 127 pts w/ CVD/CTD ILD, fibrotic interstitial pneumonia, chr hypersensitivity pneumonitis, & asbestoslung fibrosis. Pirefenidone had significantly less FVC% decline compared with placebo (p=0·043) https://t.co/H1s6ut4NhG

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Dr. Samir V. Parikh from the #SLEEducatorsNetwork discusses the major treatment goals for lupus nephritis and the broader needs of the patient in this program- Defining Treatment Goals for Lupus Nephritis. Sponsored by GSK US Medical Affairs https://t.co/f2Y707H2kR https://t.co/4xMIBp2yEh

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RNL 2021: Treatment Advances in SpA: Dr. Nigil Haroon Dr. Nigil Haroon presents Treatment Advances in SpA at RheumNow Live 2021. https://t.co/9ZA0loThx6

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News: Methotrexate Impairs COVID Vax Response https://t.co/M9d31UAxb7

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New podcast up! Download wherever podcasts are available. https://t.co/y95zS04pqw

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News: Efficacy of 6 Weeks Antibiotics with Prosthetic Joint Infections https://t.co/mSDEIKUL1h

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Danish registry study of 1,356 psoriasis and 370 PsA pts shows increased odd of coronary disease by CT Calcium scores - psoriasis w CACS ≥ 400 OR 1.25 (1.04-1.50); PsA CACS>0 OR 1.28 (1.00-1.64). Nearly a 49% incr risk in PSO (HR 1.49) https://t.co/jQSAV66TAi

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Cross-sectional study RA and PFTs, shows among 2,008 cases, RA was assoc w/ increased odds of restrictive (OR 1.36) & obstructive patterns (OR 1.21) not explained by confounders like smoking. RA had lower predicted FEV1, FVC, FEV1/FVC https://t.co/cVxatLQCG4

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Very cool article in Nature - Tissues, not blood, are where immune cells function https://t.co/NCBSBWhjTX

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Meet the #SLEEducatorsNetwork in this disease education series where leading rheumatologists and nephrologists share their perspectives on lupus nephritis. Sponsored by GSK US Medical Affairs https://t.co/H9BqP9bW4i https://t.co/5AW1IRhBrC

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RNL 2021: Best of times, worst of times (Keynote): Dr. Iain McInnes Dr. Iain McInnes presents his keynote lecture, Best of Times, Worst of Times..., at RheumNow Live 2021. https://t.co/v3hOYuJZad

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We'll be covering EULAR 2021 next week. Look for our coverage from June 3-8. https://t.co/YPNx8MBRn7
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Unable to attend the Tuesday Night Rheumatology on RA and vaccines? Watch the replay below. https://t.co/hUFTjDAnsg https://t.co/ywCRjqg1To

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Virtual DDW meeting this wk reports claims data comparing IBD to IBD with RA - IBD alone vs IBD w/ RA dx w/ more depression (21% vs 84%), anxiety (20% vs 47%). IBD w/ RA had more depression (OR 7.2); anxiety (OR, 1.25;) or both (OR, 2.3) https://t.co/B78xcJw584

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