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Zonulin levels ⬆ in pre-RA/RA pts; activation of zonulin signalling leads to ⬆ intestinal permeability.
Leaky gut - potential therapeutic target for RA?
@RheumNow #ACR20 abs#492 https://t.co/C4TVrWwcYG
sheila RHEUMarampa ( View Tweet)
RheumNow’s expanded coverage of the #ACR20 Annual meeting is sponsored in part by @Novartis. All content chosen by RheumNow & its Faculty.
Dr. John Cush RheumNow ( View Tweet)
If you are using PROs for Psoriatic Arthritis in clinic, listen to the session #ACR20 #2F044 Dr. Walsh sets out the pros and cons of PROs. The key things are patient and provider buy in, integrated IT system operability and avoid PROs fatigue and burden @RheumNow
Dr. Antoni Chan synovialjoints ( View Tweet)
UK Biobank data: RA is associated with not just restrictive but also *obstructive* patterns on spirometry/PFTs (independent of smoking).
Consistent observation; direction of causality? The lung in RA continues to fascinate.
Prisco @jeffsparks et al #ACR20 ABST0491 @RheumNow https://t.co/LcjtAefnVF
David Liew drdavidliew ( View Tweet)
Among a 402 pt PSS cohort, 10% fmet 2019 EULAR/ACR SLE Criteria. SSc-SLE overlap pts more likely to be female, AfricanAmerican, limited cut.SSc, U1RNP and have similar rates of severe SSc-specific organ damage /mortality. #ACR20 Abstr#0401 https://t.co/CVcFyx9AxS https://t.co/3SAKZ9CZGS
Dr. John Cush RheumNow ( View Tweet)
@RheumNow #ACR20 abs0083 Whole exome sequencing & HLA allele prediction in 43 Irish CNO pts show increased association w/HLA-B*27:05 (+in 17.5% pts vs 6% of the Irish population). 18.6% w/personal &18.6%family Hx of PSO. 88% of cases w/multifocal disease, 51% failed 1st line Rx
Olga Petryna DrPetryna ( View Tweet)
Better outcomes (ASAS20 and ASAS40 @wk 52) seen in younger pts (possibly lower disease duration) when Secukinumab was given to ankylosing spondylitis pts. Early Dx in #AS! #ACR20 Abstr#0350 https://t.co/EKks0b1upc https://t.co/bxIH9lloI1
Dr. John Cush RheumNow ( View Tweet)
Olmstead County (Mayo) population study shows 47 lupus nephritis (LN) pts betw 1976-2018. Incidence doubled from 1980s (0.6 per 100K) to 2018 (1.2/100K); with women of childbearing age as the most affected group. #ACR20 Abstr#0274 https://t.co/uhAMd0EtJl
Dr. John Cush RheumNow ( View Tweet)
#ACR20 2F053. What is the future for GCA imaging? @RheumNow
Eric Dein ejdein1 ( View Tweet)
Excellent session on large vessel vasculitis imaging with @petercgrayson @anisha_dua #ACR20 @RheumNow https://t.co/up5ZcGDnPt
Richard Conway RichardPAConway ( View Tweet)
Congrats to the #ACR20 Winning Image!! (click on exhibit and support tab and then on image competition to view all images) @rheumnow https://t.co/B3fcDSrfOf
k dao KDAO2011 ( View Tweet)
Still more interesting lessons from GiACTA, this time re: nature of GCA flares on TCZ:
- visual manifestation flares were rare
- ESR or CRP raised in 3/4 of flares (so not raised in 1/4)
Understanding these flares is crucial!
Unizony et al @MGHMedicine #ACR20 ABST0516 @RheumNow https://t.co/WVIitov7Ut
David Liew drdavidliew ( View Tweet)
Methotrexate and Nonalcoholic Fatty Liver Disease: Dr Eric Dein (@ejdein1)
Dr. Eric Dein discusses the findings of abstract #0181 at the #ACR20 annual meeting.
https://t.co/TzbRRbw1Kf https://t.co/vK6EahTyQ8
Links:
Dr. John Cush RheumNow ( View Tweet)
Diagnosis in GCA is changing.
Some questions from these nice Olmsted County data:
- why are dx in women declining?
- in the past, without imaging, were we missing GCA diagnoses?
It's easy to forget how far we've come in GCA!
@MayoClinic @MdWarrington #ACR20 ABST0517 @RheumNow https://t.co/QsW8BSsf1a
David Liew drdavidliew ( View Tweet)
@RheumNow #acr20 abs0063 in silico, in vitro &clinical study: Amitriptyline, naloxone& thalidomide prevent NOS2, IL6, IL1B, MMP9 release, inhibits NLRP3 inflammasome pathway> decreased colchicine consumption in gout pts using above meds for other indications #acrbest #different https://t.co/cz3htmtBU0
Olga Petryna DrPetryna ( View Tweet)
GCA phenotypic differences clearer again -
Large vessel involvement (on USS) in GCA are a/w:
- higher steroid burden
- first relapses occur later
- relapses harder to diagnose (symptoms less classical), but were a/w an IMT increase of about 25% (0.18mm)
#ACR20 ABST0518 @RheumNow https://t.co/87zVjAm9eU
David Liew drdavidliew ( View Tweet)
VA Population study shows that incident RA was less common in persons w/ HIV (PWH)(matched w/ uninfected). Only 21 RA pts in 56K PWH. PWH+/RA+ have lower autoantibodies and less likely to get DMARDs. #ACR20 Abstr#0195 https://t.co/rERJVQfq7a https://t.co/g5lATtxqOM
Dr. John Cush RheumNow ( View Tweet)
An emerging change in diagnostic (dx) modalities used in GCA? Although the leading dx modality remains a temporal a bx at 67% from 2010-2018, this is a decrease from 84% (1950-2009). Imaging is being used 19% of the time from 2010-2018 per data from Mayo Clinic. @RheumNow #ACR20 https://t.co/J97oVAGObj
Meral K. El Ramahi, MD MeralElRamahiMD ( View Tweet)
ILD in SSc has grave consequences. Abstr#393 Claims database in Ontario shows relevant Scleroderma ILD occurred in 17% of >3000 pts with nearly double the mortality #ACR20 @RheumNow @CRASCRRheum #bestinclass https://t.co/K3UXvuxBcp
Janet Pope Janetbirdope ( View Tweet)
Shoutout to @SattuiSEMD and @NavarroMillanMD showing #dementia is lower in #RA pts on bDMARDs compared to csDMARDs using CMS data #ACR20 ABS#0488 @RADoctor @RheumNow https://t.co/1XOV2zqKko
Bella Mehta bella_mehta ( View Tweet)